Modelling the Double Peak Phenomenon in pharmacokinetics.

Two methods of modelling the Double Peak Phenomenon in pharmacokinetics are described; both are based on compartmental models. The first method assumes that the absorption of the drug from the gut to the systemic plasma varies with the location of the drug in the gut, with negligible absorption through the jejunum. It has the advantage of clear physiological interpretation, but there are a comparatively large number of parameters to be estimated.