Publications by authors named "Zimcikova Eva"
Introduction: Our study aimed to investigate the effect of zonisamide (ZNS) on bone metabolism in the rat model.
Methods: Eight-week-old rats were divided into four groups. The sham-operated control group (SHAM) and the control group after orchidectomy (ORX) received the standard laboratory diet (SLD).
Article Synopsis
- Adherence to inhaled medication is a significant challenge for patients with chronic obstructive pulmonary disease (COPD), and comprehensive studies on adherence and its associated factors are limited.
- The study used data from the Czech Multicentre Research Database to evaluate overall adherence and application technique in a real-life COPD patient population, analyzing responses from 546 participants.
- Findings revealed two-thirds reported good overall adherence, but fewer than one-third applied their medication correctly; different factors influenced overall adherence and application technique, with education level, flu vaccination, and mental health being significant predictors.
Background Oral anticoagulants are established drugs of choice for the prevention and treatment of thromboembolic events. However, monitoring their safety remains warranted. Objective The aim was to analyze spontaneous reports of adverse drug reactions related to oral anticoagulants in the Czech Republic.
View Article and Find Full Text PDFBackground: There are limited data on the effects of GBP on bone and no data for PGB. Some data suggest that there is a significant influence of sex hormone balance on the susceptibility of bone to antiepileptic drug-induced bone loss.
Methods: Forty-eight male Wistar rats were divided into six groups that were subjected to two surgeries, sham (noORX) or real orchidectomy (ORX), and were fed three diets, a SLD, a SLD enriched with GBP or a SLD enriched with PGB.
Patient adherence to an inhaled medication application technique (A-ApplT) represents a major health-care issue in patients with chronic obstructive pulmonary disease (COPD). However, there is a lack of studies evaluating this issue thoroughly. The aim of our study was to introduce a universal easy-to-use method of assessing the A-ApplT to chronic medication in moderate to very severe COPD individuals.
View Article and Find Full Text PDFSome data suggest that exposure to levetiracetam (LEV) might be associated with a risk for bone health in the model of orchidectomized rats. The aim of this study was to investigate if there is any significant risk of LEV for bone health in the model of gonadally intact animals. Wistar rats were divided into a control group and a test group, 8 rats in each group.
View Article and Find Full Text PDFPurpose: Behavioral side effects of antiepileptic drugs (AEDs) are common including both positive and negative effects on mood, anxiety, depression, and psychosis. We aimed to evaluate behavioral patterns in rats after administration of lamotrigine, levetiracetam, phenytoin, topiramate, carbamazepine, gabapentin, pregabalin, and zonisamide.
Methods: The open-field test was performed and locomotion, rearing, grooming, central latency and defecation were recorded over a 5min interval for each rat (8 rats in each group receiving AED and 16 controls).
Objective: Some data suggest that exposure to lamotrigine (LTG) might be associated with impaired bone health in an orchidectomized rat model. The aim of this study was to determine if LTG poses any significant risk for bone in a gonadally intact animals and to compare the effect of LTG with that of phenytoin (PHT).
Method: Twenty-four rats were divided into control and test groups, (n=8 per group).