Publications by authors named "Ziman Xu"
Article Synopsis
- UASCC is a highly aggressive cancer characterized by elevated methionine levels, driven by the LAT1 transporter, which is uniquely activated in this type of cancer.
- Research identifies EZH2 as a critical target downstream of the LAT1-methionine pathway, linking methionine metabolism to epigenomic changes essential for tumor growth.
- Targeting this LAT1-methionine-EZH2 cascade through drugs or dietary changes presents a promising therapeutic strategy for UASCC.
Background: As one of the most common malignancies, esophageal cancer has two subtypes, squamous cell carcinoma and adenocarcinoma, arising from distinct cells-of-origin. Distinguishing cell-type-specific molecular features from cancer-specific characteristics is challenging.
Results: We analyze whole-genome bisulfite sequencing data on 45 esophageal tumor and nonmalignant samples from both subtypes.
Recently, a positive spin Hall angle (SHA) of 0.021 was observed experimentally in nonmagnetic CuIr alloys [Niimi et al, Phys. Rev.
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- Rare copy-number variation (CNV) is a significant risk factor for autism spectrum disorders (ASDs), as shown by the analysis of 2,446 ASD-affected families, revealing higher rates of genic deletions and duplications in affected individuals compared to controls.
- Affected individuals showed a notable increase in pathogenic CNVs linked to specific ASD and intellectual disability loci, with implications for various neurodevelopmental genes, including CHD2 and SETD5.
- Additionally, females with ASD had a higher prevalence of potent CNVs and were overrepresented in categories associated with fragile X syndrome, highlighting potential gender-specific factors in CNV that influence ASD.