[Clinical and experimental validation of the use of the tranquilizer mebikar as a corrective of the neuroleptic syndrome].

The results of the experimental and clinical studies showed that administration of mebikar in combination with neuroleptics reduced the degree of side effects of the neuroleptics without decreasing their antipsychotic effect.

[Pharmacological effects of combinations of psychotropic preparations used in combined pharmacotherapy].

It was shown in experiments on mice that inhibition of the exploratory activity by ftoracizin, phenazepam, scopolamine hydrobromide and their combinations predominates in comparison with muscle relaxation. Phenazepam administered at the low dose (0.025 mg/kg) by its depressive effect on the central nervous system was an antagonist of ftoracizin and a synergist of scopolamine.

[Evaluation of the nootropic effect of mebikar in clinical practice].

Mebicar therapy resulted in a reduction of the degree of deficient disorders of thinking in 27 of 50 patients with paranoid schizophrenia and normalization of indices of mental working capacity, attention and memory, shortening of the time of visual-motor disjunctive reaction in 50 patients with borderline states. Mebicar was shown to possess a nootropic effect which differs qualitatively from that of piracetam.

[Mechanisms of the antishock action of mebikar].

The tranquilizer mebicar produces an antishock action, normalizes different links of mediator, acid-base and oxygen homeostasis. Mebicar decreases arterial pressure and the tone of peripheral vessels insignificantly and for a short period.

[Effect of acetylcholine, cholinomimetics, cholinolytics and dipiroxim on the chemiluminescence of a model system of peroxidation].

Use was made of a model system initiating lipid peroxidation, that contained phosphate buffer, H2O2 and eosine. Chemiluminescence of the system decreased after addition to rat brain synaptosomes, thereby indicating the presence of antioxidants in the animals' brain. After addition of brain synaptosomes of rats poisoned with high lethal doses of armine (0.

[Comparative evaluation of antishock activity of various Soviet pharmacological agents].

On the basis of experimental and clinical studies the authors recommend to use mebikar with promedol in complex with other drugs for the treatment of traumatic shock in the prehospital and hospital periods. It was found to substantially improve results of the antishock therapy.

[Comparative analysis of the behavioral, neurochemical and autonomotropic effects of mebikar and diazepam].

It has been shown that the tranquilizers, diazepam (a 1,4-benzodiazepine derivative) and mebicar (a derivative of bicyclic bisureas) produce one-line inhibition of the production of the conditioned reflex of active avoidance in rats and of their "open-field" motor activity. Both the drugs change the balance of neuroactive amino acids in the animals' brain. However they produce different changes: diazepam increases the content of asparaginic and glutamic acids, while mebicar raises that of gamma-butyric acid.

[Protective effect of the psychotropic preparations diazepam, sodium oxybutyrate and mebikar in experimental arrhythmias].

It was shown that the psychotropic agents diazepam (1-2 mg/kg), sodium hydroxybutyrate (50-100 mg/kg) and mebicar (250-500 mg/kg) exert a protective action in experimental arrhythmias. This effect is determined by the ability of the drugs to reduce intoxication phenomena, as well as by their antihypoxic and stress-protective properties. On the other hand, the drugs exert an antiarrhythmic effect proper, interfering with potassium ion balance.

[GABA-ergic component in the action of the tranquilizing agent mebikar].

The paper is concerned with studies into the effect of the tranquilizer mebicar, a derivative of tetra-N-alkyl bicyclic bisureas, on the GABA-ergic system. The drug in doses of 250-1500 mg/kg (1/15-1/2 LD50) increased the preconvulsive period upon thiosemicarbazide administration, inconsistently changed the effects of picrotoxin and displayed antagonism in regard to bicucullin. Upon 2-week administration the drug reduced the GABA content in the rat brain.

[Effect of mebikar on the experimental and clinical course of traumatic shock].

The effect of mebikar upon the course of traumatic shock was studied on the basis of experimental investigations and clinical observations. The authors have found a positive effect of the drug on indices of acid-base state, histostructure and cellular composition of the liver whose disturbance has a great pathogenetic significance in shock. The application of mebikar considerably improved the results of treatment in clinic and reduced lethality in experiment.

[Correlation between the stress-protective and vegetotropic action of mebikar].

Mebicar, a tranquilizer of the group of tetra-N-alkyl bicyclic bis-ureas, under acute emotional stress in cats (confrontation with a dog), simultaneously with tranquilizing effect on behavior also improves central baroreflex control and reduces hypertensive reaction of the arterial pressure. In rats, it normalizes disorders of individual and intraspecies behavior induced by the stress of a long-term social isolation. It decreases the degree of ulcer injury of the stomach during the immobilization stress.

[Effect of mebikar on the state of animals under extreme conditions].

A new original tranquilizer mebicar exerts a protective action on some parameters of body function under the influence of extreme conditions (stress, hypoxia). Antihypoxic effect of the drug manifests within a wide dosage range (100-1000 mg/kg) and compares favourably with the effect of sodium hydroxybutyrate. Mebicar does not affect the muscle tone, movement coordination or working capacity of the animals.

[Characteristics of the psychotropic spectrum of action of mebicar].

Under group interaction in cats, a new Soviet tranquilizer mebicar eliminates fear-alarm induced by stimulatin of the emotiogenic zone of the hypothalamus. This action is not associated with myorelaxant or hypnotic action. Mebicar decreases the brain noradrenaline level, exerts no effect on the dopaminergic systems, increases the brain serotonin level, and does not elicit cholinolytic action.

[Pharmacological effects of the new psychotropic preparation, mebikar].

By its effects mebicar -- a derivative of bicyclic bis-ureas -- may be refered to psychotropic drugs occupying a middle position between tranquilizers and neuroleptics. The drug inhibits the orientation reaction in albino mice, potentiates the action of narcotic hypnotics, abolishes the conditioned reflex reaction of avoidance, displays central adrenolytic activity, interferes with the norepinephrine metabolism in the brain stem and modifies the permeability of the blood-encephalic barrier, like this is done by the known neuroleptics. The substance is little toxic, does not exert any direct spasmolytic action on the isolated organs.