Enhancing striatal acetylcholine facilitates dopamine release and striatal output in parkinsonian mice.

Background: L-DOPA has been considered the first-line therapy for treating Parkinson's disease (PD) via restoring striatal dopamine (DA) to normalize the activity of local spiny projection neurons (SPNs) in the direct (dSPNs) pathway and the indirect (iSPNs) pathway. While the changes in striatal acetylcholine (ACh) induced by increasing DA have been extensively discussed, their validity remains controversial. Inhibition of striatal cholinergic signaling attenuates PD motor deficits.

Distribution of microplastics in different tissues of major commercial catches in different functional areas of the South Yellow Sea.

The microplastic (MP) pollution in different tissues of six commercial catches, including (Miichthys miiuy, Eleutheronema tetradactylum, Collichthys lucidus, Mugil cephalus, Portunus trituberculatus and Exopalaemon carinicauda) in Haizhou Bay (nori farming area), Yancheng offshore (wind power construction area) and the Nantong marine ranch area of the South Yellow Sea was investigated. MPs are ubiquitous in commercial catches; the average abundance of MPs is 5.19 ± 3.

Neuroinflammation Induction and Alteration of Hippocampal Neurogenesis in Mice Following Developmental Exposure to Gossypol.

Background: Neurogenesis in the neonatal period involves the proliferation and differentiation of neuronal stem/progenitor cells and the establishment of synaptic connections. This process plays a critical role in determining the normal development and maturation of the brain throughout life. Exposure to certain physical or chemical factors during the perinatal period can lead to many neuropathological defects that cause high cognitive dysfunction and are accompanied by abnormal hippocampal neurogenesis and plasticity.