Benzoylmesaconine mitigates NLRP3 inflammasome-related diseases by reducing intracellular K efflux and disrupting NLRP3 inflammasome assembly.

Background: Benzoylmesaconine (BMA), a major alkaloid derived from the traditional Chinese medicine Aconitum carmichaeli Debx, exhibits potent anti-inflammatory properties. However, the precise mechanism underlying its action remains unclear.

Purpose: This study aimed to investigate the inhibitory mechanism of BMA on the NLRP3 inflammasome and assess its therapeutic efficacy in NLRP3-related metabolic diseases.

Piper longum L. ameliorates gout through the MAPK/PI3K-AKT pathway.

Ethnopharmacological Relevance: Gout, a painful joint disease with a prevalence ranging from 0.86% to 2.2% in China over the past decade.

Potential anti-gout properties of Wuwei Shexiang pills based on network pharmacology and pharmacological verification.

Ethnopharmacological Relevance: Wuwei Shexiang Pills (WWSX), a classic Tibetan medicine, consists of Chebulae Fructus (removed pit), Aucklandiae Radix, Moschus, Aconiti Fiavi Radix, and Acori Calami Rhizoma. It is used clinically in China to treat joint pain, swelling and other symptoms, and has the function of dispelling wind and relieving pain. However, to date, the mechanism of how it works against gout is still unclear.

Integrating network pharmacology and pharmacological validation to explore the effect of Shi Wei Ru Xiang powder on suppressing hyperuricemia.

Ethnopharmacological Relevance: Shi Wei Ru Xiang powder (SWR) is a traditional Tibetan medicinal formula with the effect of dispelling dampness and dispersing cold. In clinical practice, SWR is generally used for the treatment of hyperuricemia (HUA). However, its exact pharmacological mechanism remains unclear.