The primary challenge of applying partial denitrification/anammox (PD/A) to municipal wastewater treatment lied in the enrichment of functional bacteria with a considerable autotrophic nitrogen removal performance. The results showed influent NO-N: NH-N, reaction time and temperature would influence anammox nitrogen removal contribution. N isotopic tracing technology further revealed the average anammox contribution rate was up to 94.
View Article and Find Full Text PDFAchieving low-cost advanced nitrogen (N) removal from municipal wastewater treatment plants (WWTPs) remains a challenge. A plug-flow anaerobic/oxic/anoxic (AOA) system with a mixtures bypass (MBP) integrating partial nitrification (PN), endogenous carbon denitrification (EnD), partial denitrification (PD), and anaerobic ammonium oxidation (Anammox), was constructed to treat actual sewage with a low C/N ratio. The effluent concentrations and removal efficiency of total inorganic nitrogen (TIN) during stable operation were 2.
View Article and Find Full Text PDFThis study investigated the rapid start-up of mainstream partial denitrification coupled with anammox (PD/A) and nitrogen removal performance by inoculating precultured PD/A biofilm. The results showed mainstream PD/A in the anaerobic-anoxic-aerobic (AO) process was rapidly established within 30 days. Nitrogen removal efficiency (NRE) improved by 23.
View Article and Find Full Text PDFIntermittent hydroxylamine (NHOH) dosing strategy was applied to enhance the stability of partial nitrification and total nitrogen (N) removal efficiency (TNRE) in a continuous-flow process. The results showed 2 mg/L of NHOH dosing (once every 6 h) could maintain stably partial nitrification with nitrite accumulation rate (NAR) of 91.6 % and TNRE of 92.
View Article and Find Full Text PDFProteins and nucleic-acids are essential components of living organisms that interact in critical cellular processes. Accurate prediction of nucleic acid-binding residues in proteins can contribute to a better understanding of protein function. However, the discrepancy between protein sequence information and obtained structural and functional data renders most current computational models ineffective.
View Article and Find Full Text PDFThis study investigated the response of nitrite accumulation to elevated COD/NO-N ratio (C/N) during partial denitrification (PD). Results indicated nitrite was gradually accumulated and remained stable (C/N = 1.5 ∼ 3.
View Article and Find Full Text PDFAn anaerobic/oxic/anoxic continuous plug-flow biorereactor was established to derive stable advanced nitrogen removal of oligotrophic domestic wastewater by setting a sludge dual-reflux system and a mixed liquid cross-flow system, while extending the hydraulic retention time in anoxic section. The effluent total inorganic nitrogen was 7.9 ± 2.
View Article and Find Full Text PDFProtein-protein interactions (PPIs) govern cellular pathways and processes, by significantly influencing the functional expression of proteins. Therefore, accurate identification of protein-protein interaction binding sites has become a key step in the functional analysis of proteins. However, since most computational methods are designed based on biological features, there are no available protein language models to directly encode amino acid sequences into distributed vector representations to model their characteristics for protein-protein binding events.
View Article and Find Full Text PDFEnhancers are short non-coding DNA sequences outside of the target promoter regions that can be bound by specific proteins to increase a gene's transcriptional activity, which has a crucial role in the spatiotemporal and quantitative regulation of gene expression. However, enhancers do not have a specific sequence motifs or structures, and their scattered distribution in the genome makes the identification of enhancers from human cell lines particularly challenging. Here we present a novel, stacked multivariate fusion framework called SMFM, which enables a comprehensive identification and analysis of enhancers from regulatory DNA sequences as well as their interpretation.
View Article and Find Full Text PDFExtensive presence of aromatic organic compounds (AOCs) is a major course for the non-biodegradability of coking wastewater (COW). In-depth understanding of bio-degradation of AOCs is crucial for optimizing the design and operation of COW biological treatment systems in practical applications. Herein, the behavior and fate of AOCs were explored in a lab-scale step-feed three-stage integrated A/O biofilter (SFTIAOB) treating synthetic COW.
View Article and Find Full Text PDFIdentifying genome-wide binding events between circular RNAs (circRNAs) and RNA-binding proteins (RBPs) can greatly facilitate our understanding of functional mechanisms within circRNAs. Thanks to the development of cross-linked immunoprecipitation sequencing technology, large amounts of genome-wide circRNA binding event data have accumulated, providing opportunities for designing high-performance computational models to discriminate RBP interaction sites and thus to interpret the biological significance of circRNAs. Unfortunately, there are still no computational models sufficiently flexible to accommodate circRNAs from different data scales and with various degrees of feature representation.
View Article and Find Full Text PDFAs a core component of the biomass, the important role of extracellular polymeric substances (EPS) on treatment performance has been recognized. However, the comprehensive understanding of its correlation with nitrogen removal remains limited in biofilm-based reactors. In this study, the relevance between EPS and advanced nitrogen removal in a novel step-feed three-stage integrated anoxic/oxic biofilter (SFTIAOB) was specifically investigated.
View Article and Find Full Text PDFMitochondria are membrane-bound organelles containing over 1000 different proteins involved in mitochondrial function, gene expression and metabolic processes. Accurate localization of those proteins in the mitochondrial compartments is critical to their operation. A few computational methods have been developed for predicting submitochondrial localization from the protein sequences.
View Article and Find Full Text PDFCircular RNAs (circRNAs) are widely expressed in eukaryotes. The genome-wide interactions between circRNAs and RNA-binding proteins (RBPs) can be probed from cross-linking immunoprecipitation with sequencing data. Therefore, computational methods have been developed for identifying RBP binding sites on circRNAs.
View Article and Find Full Text PDFElectro-Fenton (EF) with peroxi-coagulation (PC) as an emerging electro-chemical advanced oxidation method has been extensively applied to treat refractory wastewater. However, the studies on the pretreatment of the raw coke plant wastewater by EF process were still lacking. In this study, a lab-scale EF system (Fe as anode and graphite as cathode) achieved the highest COD removal of 69.
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