An emergency operation strategy and motion planning method for autonomous vehicle in emergency scenarios.

Ensuring driving operational safety in emergency scenarios is paramount for autonomous vehicles to prevent accidents, particularly when vehicle motion completely depends on autonomous systems. Numerous factors must be evaluated when designing emergency collision avoidance strategies for critical situations, such as trajectory feasibility, vehicle motion stability, and driver comfort. Therefore, this study proposes a framework for emergency operation that uses collision-free area calculations to inform maneuver decisions and facilitate collision avoidance trajectory planning, preventing vehicle collisions.

Improvement of dissolution and tabletability of carbamazepine solid dispersions with high drug loading prepared by hot-melt extrusion.

Solid dispersions (SDs) have made great progress in the improvement of dissolution for poorly soluble drugs, however the low drug loading still limits their wide application. In the present paper, high carbamazepine (CBZ) loaded SDs with excellent dissolution and tabletability were prepared and characterized. The CBZ SDs were prepared with Eudragit EPO as carrier by hot-melt extrusion (HME) in the drug: carrier ratio of 4:1.

Slp-coated liposomes for drug delivery and biomedical applications: potential and challenges.

Slp forms a crystalline array of proteins on the outermost envelope of bacteria and archaea with a molecular weight of 40-200 kDa. Slp can self-assemble on the surface of liposomes in a proper environment via electrostatic interactions, which could be employed to functionalize liposomes by forming Slp-coated liposomes for various applications. Among the molecular characteristics, the stability, adhesion, and immobilization of biomacromolecules are regarded as the most meaningful.