Estradiol and Benzo[a]pyrene Co-Exposure Contributes to Lung Cancer Cell A549 Proliferation through AHR/AKT/ERK1/2 Pathway.

Objective: Estrogen may have a certain role in promoting lung cancer caused by tobacco. Our understanding of the carcinogenic effects and mechanisms of carcinogen mixture estrogen is limited and mostly relies on the findings from studying individual factors.

Methods: To test this hypothesis, an study was used to investigate the effects of 17 β-estradiol (E) on benzo[a]pyrene (Bap)-induced lung cancer cell A549 proliferation.

Predictive Value of Skeletal Muscle Function Test Combined with Climbing Test for Postoperative Cardiopulmonary Complications in Patients with COPD and Concurrent Lung Cancer.

Purpose: To explore the predictive value of skeletal muscle function measurement combined with stair climbing test for postoperative cardiopulmonary complications in patients with chronic obstructive pulmonary disease (COPD) and non-small cell lung cancer (NSCLC).

Patients And Methods: A prospective study was conducted from June 2022 to July 2023 at West China Hospital of Sichuan University, including 335 COPD patients with lung cancer who underwent surgery. The patients were divided into two groups based on the occurrence of postoperative cardiopulmonary complications: the complication group and the non-complication group.