Ion-Anchored Strategy for MnO/Mn Chemistry without "Dead Mn" and Corrosion.

The utilization of MnO/Mn chemistry in near-neutral pH acetate aqueous electrolytes provides an opportunity to achieve a higher energy density (theoretical capacity 616 mA h/g, discharge platform >1.5 V). However, this Zn-MnO aqueous battery suffers from inevitable "dead Mn" and proton corrosion.

Limiting Interfacial Free Water and Proton Concentration by Hydrogel Electrolytes for Stable MoO Anode in a Proton Battery.

Aqueous rechargeable proton batteries are attractive due to the small ionic radius, light mass, and ultrafast diffusion kinetics of proton as charge carriers. However, the commonly used acidic electrolyte is usually very corrosive to the electrode material, which seriously affects the cycle life of the battery. Here, it is proposed that decreasing water activity and limiting proton concentration can effectively prevent side reactions of the MoO anode such as corrosion and hydrogen precipitation by using a lean-water hydrogel electrolyte.

Synergistic Chaotropic Effect and Cathode Interface Thermal Release Effect Enabling Ultralow Temperature Aqueous Zinc Battery.

Although rechargeable zinc-ion batteries are promising candidates for next-generation energy storage devices, their inferior performance at subzero temperatures limits their practical application. Here, a strategy to destroy the H-bond network by adding synergistic chaotropic regents is reported, thus reducing the freezing point of the aqueous electrolyte below -90 °C. Owing to the synergistic chaotropic effect between urea and Zn(ClO ) and the thermal release effect on the cathode interface during charging, Zn//VO batteries feature a specific capacity of 111.

Application and practice of a step-by-step method combined with case-based learning in Chinese otoendoscopy education.

Background: Standardized training allows more physicians to master otoendoscopic surgery. However, the lecture-based learning (LBL) applied in otoendoscopy teaching may not be conducive to training students in clinical thinking and surgical ability. It is necessary to explore innovative methods for otoendoscopy teaching.

Effects of myeloid and plasmacytoid dendritic cells on ILC2s in patients with allergic rhinitis.

Background: Group 2 innate lymphoid cells (ILC2s) were reported to serve a critical role in allergic diseases. Myeloid dendritic cells (mDCs) and plasmacytoid DCs (pDCs) play significant roles in allergic immune response. However, effects of DCs on ILC2s in allergic diseases, especially for patients with allergic rhinitis (AR), remain unclear.

miR-511-3p protects against cockroach allergen-induced lung inflammation by antagonizing CCL2.

miR-511-3p, encoded by CD206/Mrc1, was demonstrated to reduce allergic inflammation and promote alternative (M2) macrophage polarization. Here, we sought to elucidate the fundamental mechanism by which miR-511-3p attenuates allergic inflammation and promotes macrophage polarization. Compared with WT mice, the allergen-challenged Mrc1-/- mice showed increased airway hyperresponsiveness (AHR) and inflammation.

Application of Topical Phosphodiesterase 4 Inhibitors in Mild to Moderate Atopic Dermatitis: A Systematic Review and Meta-analysis.

Importance: Topical medication is the central treatment for patients with atopic dermatitis (AD), but the options are limited. Phosphodiesterase 4 (PDE4) inhibitors are a new candidate for AD therapy.

Objective: To evaluate the efficacy and safety of topical PDE4 inhibitors in mild to moderate AD.

Identification and functional characterization of circRNA-0008717 as an oncogene in osteosarcoma through sponging miR-203.

Circular RNA (circRNA) is a key regulator in the development and progression of human cancers, however its role in osteosarcoma tumorigenesis is not well understood. The present study aims to investigate the expression profiles and potential modulation of circRNA on osteosarcoma carcinogenesis. Human circRNA microarray was performed to screen for abnormally expressed circRNA in osteosarcoma tissue and circRNA-0008717 was identified as one circRNA significantly upregulated in osteosarcoma tissue.

A tricalcium phosphate/polyether ether ketone anchor bionic fixation device for anterior cruciate ligament reconstruction: Safety and efficacy in a beagle model.

The goal of this study was to develop a bionic fixation device based on the use of a tricalcium phosphate/polyether ether ketone anchor and harvesting of the ulnar carpal flexor muscle tendon for application as a ligament graft in a beagle anterior cruciate ligament (ACL) reconstruction model, with the goal of accelerating the ligament graft-to-bone tunnel healing and providing a robust stability through exploration of this new kind of autologous ligament graft. The safety and efficacy of this fixation device were explored 3 and 6 months after surgery in a beagle ACL reconstruction model using biomechanical tests and comprehensive histological observation. The data were compared using a two-tailed Student's t test and a paired t test.

Increased Group 2 Innate Lymphoid Cells Are Correlated with Eosinophilic Granulocytes in Patients with Allergic Airway Inflammation.

The T helper 2 (Th2)-type response was considered the hypostasis of allergic airway diseases, including asthma and allergic rhinitis (AR). However, more recent studies have suggested that allergic airway inflammation also depends on innate immunity and is closely related to group 2 innate lymphoid cells (ILC2s). This study evaluated the ILC2 levels of asthma subjects, patients with asthma and AR, and healthy individuals, regarding how to investigate the relationship between clinical data and ILC2 levels.

The genes involved in asthma with the treatment of human embryonic stem cell-derived mesenchymal stem cells.

Background: Asthma is affecting more than 300 million people worldwide, which represents the most common chronic disease among children. We previously found that mesenchymal stem cells (MSCs) derived from induced pluripotent stem cells (iPSCs) modulated the immune response on Th2-mediated asthma in vivo and in vitro. This study further evaluated the immunomodulatory effects of MSCs from human embryonic stem cells (hESCs) on asthma.

Increased innate type 2 immune response in house dust mite-allergic patients with allergic rhinitis.

Group 2 innate lymphoid cells (ILC2s) are essential in initiating and driving allergic immune responses. However, there were inconsistent findings of the ILC2 levels in allergic rhinitis (AR) patients. This study investigated the ILC2 levels in the peripheral blood of house dust mite (HDM)-sensitized AR patients and their ability to secrete type 2 cytokines.

Section of the anterior cruciate ligament in the rabbit as animal model for osteoarthritis progression.

Purpose: The purpose of this study was to determine whether instability of knee is a risk factor in the progression of osteoarthritis (OA).

Methods: Twenty-four mature New Zealand White rabbits were randomly divided into four groups. The control group received 0.