Design, Synthesis, and Biological Assessment of Novel Aminobenzidazole Agonists Targeting the Stimulator of Interferon Genes (STING) Receptor Signaling Pathway for Oncology Immunotherapy.

The activation of the STING-mediated signaling pathway leads to the secretion of type I interferon (IFN) and the activation of tumor-specific T cells. STING, a pattern recognition receptor located on the endoplasmic reticulum membrane of immune cells, binds with endogenous cyclic dinucleotides. STING undergoes phosphorylation, triggering the STING-TBK1-IRF3 pathway and NF-κB pathway, resulting in the release of IFN-β and other pro-inflammatory cytokines, ultimately enhancing the activation of tumor-specific T cells.

Experimental and Theoretical Studies on the Shear Performance of Concrete Beams Reinforced with Fiber-Reinforced Polymer Stirrups.

In this paper, the shear behavior of concrete beams reinforced with FRP stirrups is studied. The shear performances of six concrete beams with a size of 150 mm × 300 mm × 3000 mm under four-point loading up to failure were experimentally analyzed. The critical parameters included the shear span to depth ratio () and stirrup spacing (S).

Cloning, expression analysis and localization of gene implicated in germ cell development of male Hezuo pig.

Deleted in azoospermia-like () is essential for mammalian testicular function and spermatogenesis. To explore the molecular characterization, expression patterns, and cellular localization of the in Hezuo pig testes, testicular tissue was isolated from Hezuo pig at five development stages including 30 days old (30 d), 90 days old (90 d), 120 days old (120 d), 180 days old (180 d), and 240 days old (240 d). cDNA was first cloned using the RT-PCR method, and its molecular characterization was analyzed using relevant bioinformatics software.

Overexpression of SIRT1 alleviates oxidative damage and barrier dysfunction in CPB2 toxin-infected IPEC-J2 cells.

Clostridium perfringens (C. perfringens) beta2 (CPB2) toxin may induce necrotizing enteritis (NE) in pigs. Sirtuin1 (SIRT1) is involved in inflammatory intestinal diseases and affects intestinal barrier function.

Cloning of and analysis of its differential expression in Hezuo pig.

The purpose of this study was to examine STC-1's structure, function, and differential expression in large and miniature pigs. We cloned the Hezuo pig's coding sequence, compared its homology, and used bioinformatics to assess the structure. RT-qPCR and Western blot were used to detect the expression in ten tissues of Hezuo pig and Landrace pig.

Exploration and Biological Evaluation of Bispecific Peptides Derived from Anti-HER2 Antibodies and Peptide-Camptothecin Conjugates for HER2-Positive Breast Cancer.

To enhance the affinity of the human epidermal growth receptor 2 (HER2) targeted peptide developed previously, bispecific fusion peptides and were designed using an approach. Molecular dynamic simulation showed that both peptides strongly interacted with HER2 domains II and IV. Compared with peptides targeting each single domain, and could bind to HER2 more significantly and targeted HER2-positive cells specifically.

Integrated analysis of miRNA and mRNA expression profiles in testes of Landrace and Hezuo boars.

Precocious puberty is closely related to testicular development and spermatogenesis, and there is increasing evidence that miRNAs are involved in regulation of testicular development and spermatogenesis. However, little is known about the regulation of microRNAs (miRNAs) during precocious maturation in Hezuo (HZ) boars. In this study, serum Testosterone (T), Estradiol (E), Follicle-stimulating hormone (FSH) and Luteinizing hormone (LH) levels were detected in HZ and Landrace (LC) boars in the postnatal period at 30, 90, 120, 180, and 240 days, and the testes of HZ and LC boars at 30 and 120 days were used for histological observation.

Experimental and Theoretical Study on Flexural Behavior of GFRP- and CFRP-Reinforced Concrete Beams after High-Temperature Exposure.

In this study, in order to study the flexural behavior of fiber-reinforced polymer (FRP) bars with reinforced concrete beams under static loads after high-temperature exposure, seven pieces of FRP-reinforced concrete beams were subjected to static bending tests and calculation model derivations. Four-point bending tests were carried out on FRP-reinforced concrete beams after high temperature treatment. The effects of high temperature and types of FRP bars on the cracking load, crack development, deflection and ultimate capacity, and failure mode of concrete beams were investigated.

Eco-Friendly, High-Ductility Slag/Fly-Ash-Based Engineered Cementitious Composite (ECC) Reinforced with PE Fibers.

Engineered cementitious composites (ECCs) are a special class of ultra-ductile fiber-reinforced cementitious composites containing a significant amount of short discontinuous fibers. The distinctive tensile strain-hardening behavior of ECCs is the result of a systematic design based on the micromechanics of the fiber, matrix, and fiber-matrix interface. However, ECCs require extensive cement content, which is inconsistent with the goal of sustainable and green building materials.

Effect of Elevated Temperature on Mechanical Properties of High-Volume Fly Ash-Based Geopolymer Concrete, Mortar and Paste Cured at Room Temperature.

This paper presents results from experimental work on mechanical properties of geopolymer concrete, mortar and paste prepared using fly ash and blended slag. Compressive strength, splitting tensile strength and flexural strength tests were conducted on large sets of geopolymer and ordinary concrete, mortar and paste after exposure to elevated temperatures. From Thermogravimetric analyzer (TGA), X-ray diffraction (XRD), Scanning electron microscope (SEM) test results, the geopolymer exhibits excellent resistance to elevated temperature.

Experimental Study on Bond Performance of Carbon- and Glass-Fiber Reinforced Polymer (CFRP/GFRP) Bars and Steel Strands to Concrete.

FRP bars and steel strands are widely used in civil engineering. In this study, three different types of high-strength reinforcement materials, carbon fiber reinforced polymer (CFRP) bar, glass fiber reinforced polymer (GFRP) bar, and steel strand, were investigated for their interfacial bond performance with concrete. A total of 90 sets of specimens were conducted to analyze the effects of various parameters such as the diameter of reinforcement, bond length, the grade of concrete and stirrup on the bond strength and residual bond strength.

Fatigue Behavior of Glass Fiber-Reinforced Polymer Bars after Elevated Temperatures Exposure.

Fiber-reinforced polymer (FRP) bars have been widely applied in civil engineering. This paper presents the results of an experimental study to investigate the tensile fatigue mechanical properties of glass fiber-reinforced polymer (GFRP) bars after elevated temperatures exposure. For this purpose, a total of 105 GFRP bars were conducted for testing.