IEEE Trans Vis Comput Graph
March 2025
Virtual Reality Video Quality Assessment (VR-VQA) aims to evaluate the perceptual quality of 360-degree videos, which is crucial for ensuring a distortion-free user experience. Traditional VR-VQA methods trained on static datasets with limited distortion diversity struggle to balance correlation and precision. This becomes particularly critical when generalizing to diverse VR content and continually adapting to dynamic and evolving video distribution variations.
View Article and Find Full Text PDFBiosensors, devices capable of detecting biomolecules or bioactive substances, have recently become one of the important tools in the fields of bioanalysis and medical diagnostics. A biosensor is an analytical system composed of biosensitive elements and signal-processing elements used to detect various biological and chemical substances. Biomimetic elements are key to biosensor technology and are the components in a sensor that are responsible for identifying the target analyte.
View Article and Find Full Text PDFThe diverse commensal microbiome of the human intestine has been considered to play a central role in depression. However, no host-microbiota co-culture system has been developed for depression, which hinders the controlled study of the interaction between depression and gut microbiota. We designed and manufactured a microfluidic-based gut-on-a-chip model containing the gut microbiota of patients with depression (depression-on-gut-chip, DoGC), which enables the extended co-culture of viable aerobic human intestinal epithelial cells and anaerobic gut microbiota, and allows the direct study of interactions between human gut microbiota and depression.
View Article and Find Full Text PDFStud Health Technol Inform
January 2024
This paper describes the implementation of tools to support multiple language variants of the clinical information models that are used to define a model-driven EHR system. Beyond that, it describes how a complete EHR system can be created with multiple language variants, using the example of an EHR for clinical management of patients in a Fracture Liaison Service. A clinical information model, represented as ontology, was developed in the English language.
View Article and Find Full Text PDFAppl Microbiol Biotechnol
July 2023
As common mental disorders, depression and anxiety impact people all around the world. Recent studies have found that the gut microbiome plays an important role in mental health. It is becoming possible to treat mental disorders by regulating the composition of the gut microbiota.
View Article and Find Full Text PDFBackground: Psychological health risk is one of the most severe and complex risks in manned deep-space exploration and long-term closed environments. Recently, with the in-depth research of the microbiota-gut-brain axis, gut microbiota has been considered a new approach to maintain and improve psychological health. However, the correlation between gut microbiota and psychological changes inside long-term closed environments is still poorly understood.
View Article and Find Full Text PDFAppl Microbiol Biotechnol
April 2023
The desynchronization of circadian rhythms affected by light may induce physiological and psychological disequilibrium. We aimed to elucidate changes of growth, depression-anxiety like behaviors, melatonin and corticosterone (CORT) secretion, and gut microbiota in rats influenced by long-term light inputs. Thirty male Sprague-Dawley rats were exposed to a 16/8 h light/dark regime for 8 weeks.
View Article and Find Full Text PDFBackground: Chinese Lunar Palace 1 (LP1) is a ground-based bio-regenerative life support system (BLSS) test bed integrating highly efficient plant cultivation, animal protein production, urine nitrogen recycling, and bioconversion of solid waste. To date, there has been no molecular method-based detailed investigation of the fungal community and mycotoxin potential in BLSS habitats. To ensure safe BLSS design for actual space missions, we analyzed the LP1 surface mycobiome and mycotoxin potential during the Lunar Palace 365 project through internal transcribed spacer region 1 (ITS1) amplicon sequencing and quantitative polymerase chain reaction (qPCR) with primers specific for idh, ver1, nor1, tri5, and ITS1.
View Article and Find Full Text PDFSubhealth is a condition between health and disease that has become a common public health risk. Therefore, it is necessary to find more scientific therapies that can alleviate the symptoms of subhealth effectively. The gut microbiota is closely associated with subhealth.
View Article and Find Full Text PDFIncreasing evidences indicate that gut microbiota composition is associated with multiple inflammatory diseases. However, little is known about how gut microbiota changes with age and correlations with gut inflammation at sexual maturity stage of healthy individuals. Elucidating the dynamic changes of gut microbiota in healthy individuals at the sexual maturity stage and correlations with gut inflammation can provide clues for early risk assessment of gut diseases at the sexual maturity stage.
View Article and Find Full Text PDFThe long-term exposure to enclosed environments may lead to chronic stress in crewmembers and affect their physical and mental state. Salivary microbiome and biomarkers of immune function are increasingly used in human health research. The "Lunar Palace 365" project, which was a 370-day, multicrew, enclosed experiment carried out in a ground-based bioregenerative life support system platform named Lunar Palace 1 (LP1).
View Article and Find Full Text PDFPsychoneuroendocrinology
February 2022
Antibiotics exposure leads to gut microbiota dysbiosis, which increases the risk of anxiety and depression. However, the impact of ciprofloxacin and metronidazole exposure on chronic unpredictable mild stress-induced anxiety-like and depression-like behavior and underlying regulatory mechanism have not been well established. Here, chronic unpredictable mild stress model was established in adult male Sprague-Dawley rats.
View Article and Find Full Text PDFJ Am Soc Mass Spectrom
July 2020
Metaproteomics has been used in combination with gut microbiota models to study drug-microbiome interactions. However, it remains unexplored whether the metaproteomics profile of gut microbiota responds differently to a same stimulus added at different growth phases. In this study, we cultured a human gut microbiota in 96-deep well plates using a previously validated model.
View Article and Find Full Text PDFCrewmembers are working and living in isolated environment lacking natural light and perception. Although their health problems have been documented, the mechanism has not been thoroughly investigated. The aim of the present study is to investigate the psychological and physiological influences of isolated environment on crewmember's health.
View Article and Find Full Text PDFRecent studies have suggested that the gut microbiome is modified in space analogs and that human health can be affected during actual spaceflight. However, the relationship between the gut microbiome and dietary intake in simulator subjects and astronauts remains unclear. Bioregenerative life support systems (BLSSs) are confined and self-sufficient ecosystems that enable exploration of this issue.
View Article and Find Full Text PDFIn this study, we report that optimal coordination-site exposure engineering in porous platinum brings ultrahigh activity and durability for the fuel cell oxygen reduction reaction (ORR). The porous platinum with numerous grain boundaries (GBP-Pt) consisting of 3 nm crystals exhibits 7 times higher ORR activity than commercial Pt. For fuel-cell measurements, the GBP-Pt catalyst based MEA exhibits high power density (1.
View Article and Find Full Text PDFThe realization that the microbiota-gut-brain axis plays a critical role in health and disease,including neuropsychiatric disorders, is rapidly advancing.An abundance of preclinical studies have shown that psychobiotics acting via the brain-gut-axis can affect brain development, function and behavior. Here we tested whether potential psychobiotics Faecalibacterium prausnitzii (ATCC 27766) has anxiolytic and antidepressant-like effects and reverse the impact of chronic unpredictable mild stress (CUMS) in rats. The experiment was divided into two phases, the first stage was CUMS procedure period and the second stage was convalescence period.
View Article and Find Full Text PDFUnderstanding the dynamics of human gut microbiota in space is crucial in maintaining astronaut health. Long-duration and deep-space manned exploration will require the in situ regeneration of resources, which would be achieved by an artificial ecosystem, such as a bioregenerative life-support system (BLSS). Potential response of human gut microbiota to particular lifestyle and dietary structure experienced in a BLSS remains unclear.
View Article and Find Full Text PDFElectrochemical water splitting to produce hydrogen renders a promising pathway for renewable energy storage. Considering limited electrocatalysts have good oxygen-evolution reaction (OER) catalytic activity in acid solution while numerous economical materials show excellent OER catalytic performance in alkaline solution, developing new strategies that enhance the alkaline hydrogen-evolution reaction (HER) catalytic activity of cost-effective catalysts is highly desirable for achieving highly efficient overall water splitting. Herein, it is demonstrated that synergistic regulation of water dissociation and optimization of hydrogen adsorption free energy on electrocatalysts can significantly promote alkaline HER catalysis.
View Article and Find Full Text PDFSheng Wu Gong Cheng Xue Bao
January 2015
Thioesterase catalyzes the hydrolysis of acyl-ACP and saturated fatty acyl chain. It plays a key role in the accumulation of medium chain fatty acids in vivo. In this study, to construct an engineering strain to produce MCFAs, the Arabidopsis acyl-ACP thioesterase gene AtFatA was amplified by PCR from cDNA of arabidopsis and double digested by EcoR I/Xba I, then linked to the plasmid digested with same enzymes to get the recombinant plasmid pPICZaA-AtFatA.
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