The correlation between the atherogenic index of plasma and the severity of coronary artery disease in acute myocardial infarction patients under different glucose metabolic states.

The atherogenic index of plasma (AIP) is a recent biomarker linked to atherosclerosis that has been validated as a novel indicator for myocardial infarction (MI). However, the relationship between AIP and the severity of coronary artery disease (CAD) in MI patients is still ambiguous, particularly among individuals with different glucose metabolic conditions. A total of 741 participants who were immediately assessed with coronary angiography upon admission and diagnosed with acute MI were recruited.

Biotic and Abiotic Drivers of Ecosystem Temporal Stability in Herbaceous Wetlands in China.

Maintaining the stability of ecosystems is critical for supporting essential ecosystem services over time. However, our understanding of the contribution of the diverse biotic and abiotic factors to this stability in wetlands remains limited. Here, we combined data from a field vegetation survey of 725 herbaceous wetland sites in China with remote sensing information from the Enhanced Vegetation Index (EVI) from 2010 to 2020 to explore the contribution of biotic and abiotic factors to the temporal stability of primary productivity.

Efficiency of combination therapy versus monotherapy for the treatment of infections due to carbapenem-resistant Gram-negative bacteria: a systematic review and meta-analysis.

Background: For resistant Gram-positive bacteria, evidence suggests that combination therapy is more effective. However, for resistant Gram-negative bacteria, no consensus has been reached. This study aims to comprehensively summarize the evidence and evaluate the impact of combination versus monotherapy on infections caused by carbapenem-resistant Gram-negative bacteria (CRGNB).

The Role of Cardiac Macrophages in Inflammation and Fibrosis after Myocardial Ischemia-Reperfusion.

According to current statistics, the mortality rate of cardiovascular diseases remains high, with coronary artery disease being the primary cause of death. Despite the widespread adoption of percutaneous coronary intervention (PCI) in recent years, which has led to a notable decrease in the mortality rate of myocardial infarction (MI), the pathological cardiac remodeling and heart failure that follow myocardial infarction still pose significant clinical challenges. Myocardial ischemia-reperfusion (MIR) injury represents a complex pathophysiological process, and the involvement of macrophages in this injury has consistently been a subject of significant focus.

The functions of apolipoproteins and lipoproteins in health and disease.

Lipoproteins and apolipoproteins are crucial in lipid metabolism, functioning as essential mediators in the transport of cholesterol and triglycerides and being closely related to the pathogenesis of multiple systems, including cardiovascular. Lipoproteins a (Lp(a)), as a unique subclass of lipoproteins, is a low-density lipoprotein(LDL)-like particle with pro-atherosclerotic and pro-inflammatory properties, displaying high heritability. More and more strong evidence points to a possible link between high amounts of Lp(a) and cardiac conditions like atherosclerotic cardiovascular disease (ASCVD) and aortic stenosis (AS), making it a risk factor for heart diseases.

Dibenzothiophene S, S-Dioxide-Containing Dipolar Molecules As Efficient Hole-Transport Materials for Perovskite Solar Cells.

Organic-inorganic hybrid perovskite solar cells (OIH-PSCs) have developed rapidly in the past decade, and the commercialization of OIH-PSCs demands low-cost hole-transport materials (HTMs) with high performance and stability. The present study synthesized two organic HTMs containing dibenzothiophene S-dioxide as the acceptor unit and triphenylamine as the donor (denoted by TPAF-SO2 and TPA-SO2). In TPAF-SO, the methoxy group and adjacent fluorine atom were introduced to decrease the highest occupied molecular orbital energy level.

Factors influencing mortality in intracranial infections caused by carbapenem-resistant Klebsiella Pneumoniae.

It remains that intracranial infection has an alarming mortality and morbidity. Klebsiella pneumoniae (KP) have increasingly been isolated in ventriculitis and meningitis episodes. Intracranial infections caused by carbapenem-resistant Klebsiella pneumoniae (CRKP) account for high mortality.

Ultrasound-Responsive Nanodelivery System of GPC3-Targeting and Sonosensitizer for Visualized Hepatocellular Carcinoma Therapy.

Purpose: The incidence of hepatocellular carcinoma (HCC) is continuously increasing, and the mortality rate remains high. Thus, more effective strategies are needed to improve the treatment of HCC.

Methods: In this study, we report the use of a visualized glypican-3 (GPC3)-targeting nanodelivery system (named GC-NBs) in combination with sonodynamic therapy (SDT) to enhance the therapeutic efficacy for treating HCC.

Advances in antitumor application of ROS enzyme-mimetic catalysts.

The rapid growth of research on enzyme-mimetic catalysts (Enz-Cats) is expected to promote further advances in nanomedicine for biological detection, diagnosis and treatment of disease, especially tumors. ROS-based nanomedicines present fascinating potential in antitumor therapy owing to the rapid development of nanotechnology. In this review, we focus on the applications of Enz-Cats based on ROS in antitumor therapy.

High mortality associated with inappropriate initial antibiotic therapy in hematological malignancies with Klebsiella pneumoniae bloodstream infections.

Bloodstream infections caused by multidrug-resistant organisms such as Klebsiella pneumoniae are a significant challenge in managing hematological malignancies. This study aims to characterize the epidemiology of Klebsiella pneumoniae bloodstream infections specifically in patients with hematological malignancies, delineate the patterns of initial antibiotic therapy, assess the prevalence of resistant strains, identify risk factors for these resistant strains, and evaluate factors influencing patient outcomes. A retrospective analysis was conducted at a single center from January 2017 to December 2020, focusing on 182 patients with hematological malignancies who developed Klebsiella pneumoniae bloodstream infections.

[Risk factors for cow's milk protein allergy in infants: a multicenter prospective nested case-control study].

Objectives: To explore the risk factors associated with cow's milk protein allergy (CMPA) in infants.

Methods: This study was a multicenter prospective nested case-control study conducted in seven medical centers in Beijing, China. Infants aged 0-12 months were included, with 200 cases of CMPA infants and 799 control infants without CMPA.

Comparative genomics and host range analysis of four Ralstonia pseudosolanacearum strains isolated from sunflower reveals genomic and phenotypic differences.

Background: Bacterial wilt caused by Ralstonia solanacearum species complex (RSSC) is one of the devastating diseases in crop production, seriously reducing the yield of crops. R. pseudosolanacearum, is known for its broad infrasubspecific diversity and comprises 36 sequevars that are currently known.

[Association of pregnancy factors with cow's milk protein allergy in infants].

Objective: To preliminarily explore the association of pregnancy factors with cow's milk protein allergy in infants.

Methods: This study was based on data from a subcohort of a study called genetic susceptibility to cow's milk allergy in Chinese children, including infants born in Peking University People's Hospital between March 1, 2020, and December 31, 2020. The infants were divided into a cow's milk protein allergy (CMPA) group and a control group according to whether they had developed cow's milk protein allergy at the age of 1 year.

Visualization of therapeutic intervention for acute liver injury using low-intensity pulsed ultrasound-responsive phase variant nanoparticles.

Acute liver injury (ALI) is a highly fatal condition characterized by sudden massive necrosis of liver cells, inflammation, and impaired coagulation function. Currently, the primary clinical approach for managing ALI involves symptom management based on the underlying causes. The association between excessive reactive oxygen species originating from macrophages and acute liver injury is noteworthy.

Spatiotemporal patterns of urban forest carbon sequestration capacity: Implications for urban CO emission mitigation during China's rapid urbanization.

Urban forests provide ecological functions and human well-being. However, spatiotemporal changes in urban forest carbon sequestration (CS) under rapid urbanization remain poorly understood. We established a model to predict the annual CS dynamics in urban forests based on plot-measured CS and Landsat images.

Rapid urbanization and meteorological changes are reshaping the urban vegetation pattern in urban core area: A national 315-city study in China.

Urban vegetation takes on the responsibility of improving the urban environment and human wellbeing. However, the changing pattern and its driving mechanism are still not well understood at the national scale, especially in China under nearly 20 years-long rapid urbanization. In this study, for urban core area in 315 cities, over 18,000 high-resolution remote sensing images across 18 years were used to detect the spatiotemporal changes of urban vegetation and furtherly explore the interaction and independence of rapid urbanization and meteorological change.

Research Progress on the GIP/GLP-1 Receptor Coagonist Tirzepatide, a Rising Star in Type 2 Diabetes.

Type 2 diabetes mellitus (T2DM) is a chronic progressive metabolic disease that has become a growing health problem worldwide, and the dangers of hyperglycemia and its chronic complications have long been considered a goal of diabetes treatment. In recent years, tirzepatide has become the first dual GIP/GLP-1R agonist approved for the treatment of diabetes mellitus in the United States as a new hypoglycemic medicine. Its hypoglycaemic and weight loss effects have been demonstrated in several large clinical trials, and there is also evidence that it has great potential for cardiovascular protection.

Clinical Characteristics and Prognosis Analysis of Bloodstream Infection Based on Propensity Matching.

Purpose: In view of the fact that bloodstream infection(BSI) is a great threat to human survival, early identification of the risk factors affecting prognosis will be of great benefit to the clinic.

Patients And Methods: A propensity score matching method was used to collect patients identified with BSI from 2016 to 2020 from a reputable hospital in China.

Results: A total of 398 patients were considered.

Colchicine and coronary heart disease risks: A meta-analysis of randomized controlled clinical trials.

Background: Several trials have considered the safety and clinical benefits of colchicine as a treatment option for secondary prevention in patients with coronary atherosclerotic heart disease (CAD), but its safety and clinical benefits remain controversial. The purpose of this study was to explore the clinical benefits of colchicine, focusing on certain subgroups of patients.

Methods: Randomized controlled trials (RCTs) of colchicine in subjects with acute or chronic CAD compared with controls were included to assess all-cause mortality, non-cardiovascular mortality, gastrointestinal adverse effects, diarrhea, MACE, cardiovascular mortality, MI, stroke, and revascularization.

Serum Tenascin-C and Alarin Levels Are Associated with Cardiovascular Diseases in Type 2 Diabetes Mellitus.

Background: Tenascin-C (TNC), an extracellular matrix glycoprotein, is elevated in inflammatory and cardiovascular pathologies, whereas alarin, a novel orexigenic peptide, participates in insulin resistance and glycometabolism. The roles of these molecules in individuals with cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM), clinical conditions associating with metabolic disorders, and chronic inflammation, remain controversial. Our study aimed at determining the potential role of TNC and alarin in CVD adult patients with T2DM.

Genetic susceptibility to cow's milk allergy in Chinese children.

Background And Objectives: Cow's milk allergy (CMA) is the most common food allergy in young children. Previous studies have reported that single-nucleotide polymorphisms (SNPs) are associated with CMA. The extent to which SNPs contribute to the occurrence of CMA is unknown.

Ultralow magnetic damping of a common metallic ferromagnetic film.

For most magnetic materials, ultralow damping is of key importance for spintronic and spin-orbitronic applications, but the number of materials suitable for charge-based spintronic and spin-orbitronic applications is limited because of magnon-electron scattering. However, some theoretical approaches including the breathing Fermi surface model, generalized torque correlation model, scattering theory, and linear response damping model have been presented for the quantitative calculation of transition metallic ferromagnet damping. For the Fe-Co alloy, an ultralow intrinsic damping approaching 10 was first theoretically predicted using a linear response damping model by Mankovsky and then experimentally observed by Schoen Here, we experimentally report a damping parameter approaching 1.

Two new species of cavernicolous trechines from central Guizhou and northwestern Guangxi, China (Coleoptera: Carabidae: Trechinae).

Two highly modified new species of cave-adapted trechine beetles are described from Guizhou Province and Guangxi Zhuang Autonomous Region: Sinaphaenops (Sinaphaenops) chengguangyuani n. sp. (Guizhou: Longli: cave Shuijing Dong), belonging to the banshanicus species group of the genus Sinaphaenops Uéno Wang, 1991; Giraffaphaenops brevicephalus n.

A new anophthalmic trechine genus and two new species from southern Guizhou, China (Coleoptera: Carabidae: Trechini).

A new genus and two new species of cavernicolous trechine beetles are reported from southern Guizhou Province, Southwest China: Miaotrechus mahua n. gen., n.

Discovery of a cavernicolous trechine species from the Sanwang Dong-Erwang Dong cave system, Wulong, Chongqing, southwestern China (Coleoptera: Carabidae: Trechinae).

Qianaphaenops (Sanwangius) rowselli Tian et Chen, n. subgen., n.