A novel nanoprobe for multimodal instantaneous detection of tiopronin and tetracycline hydrochloride.

Tiopronin (TP) is a common reagent used in clinical therapy and can cause problems such as myasthenia gravis and gastrointestinal disturbance if not used in the correct dose. Tetracycline (TC) is a class of antibiotic drugs whose long-term accumulation in the body poses a serious threat. Currently, these two substances are mostly detected in a single mode, susceptible to environmental and operational factors.

Regulation of CD73 on NAD metabolism: Unravelling the interplay between tumour immunity and tumour metabolism.

CD73, a cell surface-bound nucleotidase, serves as a crucial metabolic and immune checkpoint. Several studies have shown that CD73 is widely expressed on immune cells and plays a critical role in immune escape, cell adhesion and migration as a costimulatory molecule for T cells and a factor in adenosine production. However, recent studies have revealed that the protumour effects of CD73 are not limited to merely inhibiting the antitumour immune response.

The causal relationship between immune cells and different kidney diseases: A Mendelian randomization study.

Studies have suggested that the progress of most kidney diseases from occurrence to course and subsequent related complications are closely related to inflammatory reaction. Increased common leukocytes count in the family (neutrophils, eosinophils, basophils, lymphocytes, etc.) are also involved in the tissue damage of kidney diseases.

Construction and evaluation of a column chart model and a random forest model for predicting the prognosis of hydrodistention surgery in BPS/IC patients based on preoperative CD117, P2X3R, NGF, and TrkA levels.

Objective: This study seeks to investigate independent risk factors affecting the prognoses of patients with bladder pain syndrome/interstitial cystitis (BPS/IC) following hydrodistention surgery and to develop a column chart model and a random forest model to help predict clinical outcomes.

Method: A retrospective analysis was conducted on the clinical data of 1006 BPS/IC patients who visited the urology department of the Fifth Hospital of Shanxi Medical University (Shanxi Provincial People's Hospital) between June 2012 and June 2022. The patients were randomly divided into a model group (n = 704) and a validation group (n = 302).

Research on symptoms composition, time series evolution, and network visualisation of interstitial cystitis based on complex network community discovery algorithm.

We analyzed the symptoms composition of Interstitial Cystitis (IC), the regularity of the evolution of symptoms before and after treatment, and the visualization of the community network, to provide a reference for clinical diagnosis and treatment of Interstitial Cystitis. Based on the outpatient electronic case data of 552 patients with Interstitial Cystitis, we used a complex network community discovery algorithm, directed weighted complex network, and Sankey map to mine the data of the symptoms composition of Interstitial Cystitis, the evolution of symptoms before and after treatment and the visualization of the community network, to analyze the epidemiological characteristics of interstitial cystitis symptoms in the real world. By the community division of the complex network of interstitial cystitis symptoms, We finally obtained three core symptom communities.

Amorphous copper(II)-cyanoimidazole frameworks as peroxidase mimics for hydrogen sulfide assay.

Metal-organic frameworks with hierarchical porosities and exposed active sites are promising for ideal enzyme mimics. In this work, we developed a simple and feasible air oxidation strategy to prepare amorphous Cu(II)-cyanoimidazole frameworks (aCu(II)-CIFs) using CuI as the metal source in dimethylsulfoxide. Benefiting from coordination unsaturation and hierarchical porosities, aCu(II)-CIFs exhibit inherent peroxidase-mimic activity for rapid colorimetric reaction of 3,3',5,5'-tetramethylbenzidine (TMB).

The safety and effectiveness of laparoscopic anterior sacral ligament suspension combined with dome suspension in the treatment of bladder prolapse after hysterectomy: a retrospective cohort study.

Background: Laparoscopic anterior sacral ligament suspension combined with dome suspension (L-ASLS + DS) and transperineal whole pelvic floor reconstruction (T-WPFR) are 2 methods for treating bladder prolapse after hysterectomy. In clinical practice, we found that L-ASLS + DS has better safety and effectiveness than T-WPFR, but there is no relevant study comparing the safety and effectiveness of these two methods. We sought to compare the efficacy and safety of L-ASLS + DS and T-WPFR in treating hysterectomy-induced bladder prolapse overa 1-year follow-up period.

Causal relationship between smoking status, smoking frequency and bladder cancer: a Mendelian randomization study.

Background: Smoking is a well-established risk factor for bladder cancer. However, it remained unclear that whether smoke status and smoke frequency increase bladder cancer.

Objective: We aim to explore the causal relationship between smoking status, smoking frequency and the risk of bladder cancer by Mendelian randomization.

The causal association between maternal smoking around birth on childhood asthma: A Mendelian randomization study.

To explore the causal relationship between maternal smoking around birth and childhood asthma using Mendelian randomization (MR). Using the data from large-scale genome-wide association studies, we selected independent genetic loci closely related to maternal smoking around birth and maternal diseases as instrumental variables and used MR methods. In this study, we considered the inverse variance weighted method (MR-IVW), weighted median method, and MR-Egger regression.

HPV-16 Expression and Loss of Cell Differentiation in Primary Bladder Tumors.

Objective: Primary bladder tumors have a high degree of malignancy. To investigate the expression of human papillomavirus type 16 (HPV-16) in primary bladder tumors and the loss of cell differentiation and to explore the significance of HPV-16 detection, it is expected to be a disease. Treatment provides a theoretical basis.

Application of IgG antibody titer and subtype in diagnosis and severity assessment of hemolytic disease of the newborn.

Background: To analyze the effect of different times of pregnancy of type O pregnant women on the occurrence of ABO hemolytic disease of the newborn (ABO-HDN).

Methods: From December 2018 to December 2021, 725 pregnant women with O blood group (husbands with non-O blood group) who met the inclusion criteria were collected. There were 116 cases of ABO-HDN, which were summarized and analyzed.

Investigation of the extended focusing capability of the spherical aberration to enlarge the field of view in light-sheet fluorescence microscopy.

In light-sheet fluorescence microscopy (LSFM), using Gaussian beams for light-sheet generation results in a trade-off between the thickness and the field of view (FOV). Here we present a theoretical analysis of using spherical aberration to enlarge the FOV while keeping the light-sheet thickness small. Such spherical aberration can arise when focusing beams through an interface between materials of mismatched refractive indices.

Plasma-Enhanced Atomic Layer Deposition of Cobalt Films Using Co(EtCp) as a Metal Precursor.

For advanced Cu interconnect technology, Co films have been widely investigated to serve as the liner and seed layer replacement because of a better wettability to Cu than Ta. In this article, the Co films are grown by plasma-enhanced atomic layer deposition using Co(EtCp) as a precursor, and the influences of process parameters on the characteristics of the Co films are elaborately investigated. The results indicate that the process window is 125-225 °C with a growth rate of ~ 0.