Insights into the streamwater age in the headwater catchments covered by glaciers and permafrost, Central Tibetan Plateau.

Improving our understanding of streamwater age knowledge is critical for revealing the complex hydrological processes in alpine cryosphere catchments. However, few studies on water age have been conducted in alpine cryosphere catchments due to the complicated and inclement environment. In this study, the Buqu catchment, a typical alpine catchment covered by glaciers and permafrost on the central Tibetan Plateau (TP), was selected as the study area.

Restoring perturbed oxylipins with Danqi Tongmai Tablet attenuates acute myocardial infarction.

Salvianolic acids have a special synergic effect on panax notoginsenosides in acute myocardial infarction (AMI) and have been developed into a new drug as Danqi Tongmai Tablet (DQTT). To explore candidate targets and mechanisms of DQTT on AMI, a network pharmacology-based analysis was performed on absorbed prototype compounds of DQTT in rat plasma. Target prediction from network analysis indicated that the arachidonic acid pathway might contribute to the therapeutic effects of DQTT on AMI, and the regulatory effects on cyclooxygenase (COX) and lipoxygenase (LOX) were validated using an oxygen-glucose deprivation/reoxygenation model established on H9c2 cardiomyocytes.

Assessing glacier retreat and its impact on water resources in a headwater of Yangtze River based on CMIP6 projections.

Glacier retreat caused by global warming alters the hydrological regime and poses far-reaching challenges to water resources and nature conservation of the headwater of Yangtze River, and its vast downstream regions with dense population. However, there is still lack of a robust modeling framework of the "climate-glacier-streamflow" in this water tower region, to project the future changes of glacier mass balance, glacier geometry, and the consequent impacts on runoff. Moreover, it is imperative to use the state-of-the-art sixth phase Coupled Model Intercomparison Project (CMIP6) to assess glacio-hydrology variations in future.

[Fluvastatin's effect on atherogenesis in apolipoprotein-E knockout mice infected by cytomegalovirus].

Objective: The goal of this study was to investigate whether murine cytomegalovirus (MCMV) is able to exacerbate the atherosclerotic process in apolipoprotein E knockout (apoE -/-) mice, and the effect of fluvastatin on the atherogenesis.

Methods: The apoE-/- mice kept on a west diet were given low dosage of MCMV. At 14,18 and 24 weeks post infection, AS lesion were measured on aorta.

[Analysis of 62 adult patients with viral meningitis].

Objective: To investigate the clinical manifestation, cerebrospinal fluid (CSF) and auxiliary examination findings of adult viral meningitis.

Methods: 62 adult patients with viral meningitis were retrospectively analyzed.

Results: Headache occurred in all the 62 (100%) patients, fever occurred in 61 (98%) patients, meningeal irritation sign occurred in 48 (77%) patients.

[Relationship between EB virus, Cytomegalo virus, herpes simplex virus and coxsackievirus infection and relapse of multiple sclerosis].

Objective: To study the relation between the recent active infection with Epstein-Barr virus, cytomegalovirus,herpes simplex virus-1, coxsackievirus B I-IV and the relapse of relapsing-remitting multiple sclerosis (RR MS).

Methods: Using ELISA method, IgM antibodies to Epstein-Barr virus, cytomegalovirus, herpes simplex virus-1, coxsackievirus BI-IV in the plasma from 34 RR MS patients and 200 normal controls were detected. The rates of recent active infection with the above mentioned viruses of the patients and controls were compared.

Detection of human cytomegalovirus in atherosclerotic carotid arteries in humans.

Background/purpose: Atherosclerosis plays an important role in stroke. A microbiological infection has been suggested to be involved in the pathogenesis of atherosclerosis, in particular the human cytomegalovirus (HCMV). The objective of this study was to determine the association between HCMV infection and atherosclerosis of the internal carotid arteries in patients of Chinese Han ethnicity with ischemic stroke.

The expression of human brain vascular smooth muscle cell AT receptor after the UL83 gene of HCMV inhibition by small interfering RNAs.

Objectives: To explore the role of angiotensin receptors (AT1 and AT2) and human cytomegalovirus (HCMV) infection in atherosclerosis, and to observe effect of HCMV UL83 gene on angiotensin receptor AT receptors.

Methods: Cell model of RNA interference (RNAi) HCMV UL83 gene was set up by transfection RNAi into HCMV infected human cerebral artery vascular smooth muscle cells cultured in vitro by application of transfection technique and adoption of RT-PCR, etc. Effect of HCMV on gene expression of AT1 and AT2 receptors in human cerebral artery vascular smooth muscle cells cultured in vitro under the action of Ganciclovir (GCV), AT1 and AT2 receptor antagonists by immunofluorescence technique, RT-PCR and protein electrophoresis.

[Acute transverse myelitis associated with coxsackievirus B---A retrospective analysis of 7 patients].

Objective: Acute Transverse myelitis (ATM) is a focal inflammatory disorder of the spinal cord, resulting in motor, sensory, and autonomic nerve dysfunction. There is often a clearly defined rostral border of sensory dysfunction. Nowadays, the pathogenesis of ATM is not clear.

[Effect of cytomegalovirus infection on expression of matrix metalloproteinase-2 in human endothelial cells].

Objective: To investigate the effect of cytomegalovirus infection on expression of matrix metalloproteinase-2 in human endothelial cells.

Methods: Human umbilical vein endothelial cells were cultured in vitro. Cells between 3-6 passages were infected with cytomegalovirus for different time.

[Clinical characteristics of patients with chronic fatigue syndrome: analysis of 82 cases].

Objective: To analyze the clinical characteristics of Chinese patients suffering from chronic fatigue syndrome (CFS) and provide clinical and laboratory evidence for the study of its etiology and treatment.

Methods: 82 patients with CFS diagnosed based on the CDC criteria 1994 were recruited. History was collected, and physical examination was made.

[Expression of human cytomegalovirus immediate early gene in the intracranial artery walls of atherosclerosis].

Objective: Human cytomegalovirus (HCMV), especially the immediate early (IE) gene of the virus, has been implicated in the pathogenesis of atherosclerosis. The aim of this study was to confirm the presence of HCMV IE gene DNA in intracranial artery walls and the association of the virus with the development of atherosclerosis.

Methods: HCMV IE gene was tested in formaldehyde-fixed intracranial arteries from 35 cases with cerebral atherosclerosis and 20 negative controls.

[Effect of HSV-1 infection on the viability of the primary cultured chicken embryo telencephalon neurons].

Objective: To observe the effect of HSV-1 infection on the viability of the cultured chicken embryo telencephalon neurons in vitro.

Methods: Primary culture model of chicken embryo of telencephalon neurons was established. Herpes simplex virus type 1 (HSV-1) was propagated in Vero cells and viral titer was measured by plaque forming method.