Reckless crossing behaviour is one of the major contributing factors to pedestrian crashes and injuries. The relationship between perceived risk and actual behaviour of pedestrians was examined. However, influences of weather conditions, which is a significant crash contributory factor, on the pedestrian safety perception are less studied.
View Article and Find Full Text PDFLane changing behaviour occurs frequently on the highways. However, it also poses a major impact on traffic operation and safety since complex interactions between two or more vehicles on different traffic lanes are involved. In the lane-changing related crashes, correlation in damage level among the vehicles involved is prevalent.
View Article and Find Full Text PDFUveal melanoma (UM) poses a significant lethality, with approximately 50% of those developing metastases surviving less than one year. In the progression of UM, vasculogenic mimicry (VM) induced by hypoxia plays a pivotal role, which also partially explains the resistance of UM to anti-angiogenic therapies. Nevertheless, the crucial molecular mechanisms underlying VM in the progression of UM remain unclear.
View Article and Find Full Text PDFBackground: Diabetic retinopathy (DR) is the most important complication of Type 2 Diabetes (T2D) in eyes. Despite its prevalence, the early detection and management of DR continue to pose considerable challenges. Our research aims to elucidate potent drug targets that could facilitate the identification of DR and propel advancements in its therapeutic strategies.
View Article and Find Full Text PDFInnate immune cells, crucial in resisting infections and initiating adaptive immunity, play diverse and significant roles in tumor development. These cells, including macrophages, granulocytes, dendritic cells (DCs), innate lymphoid cells, and innate-like T cells, are pivotal in the tumor microenvironment (TME). Innate immune cells are crucial components of the TME, based on which various immunotherapy strategies have been explored.
View Article and Find Full Text PDFTwo-dimensional (2D) ferromagnetic semiconductors (FM SCs) provide an ideal platform for the development of quantum information technology in nanoscale devices. However, many developed 2D FM materials present a very low Curie temperature (T), greatly limiting their application in spintronic devices. In this work, we predict two stable 2D transition metal chalcogenides, VSeX (X = S, Te) monolayers, by using first-principles calculations.
View Article and Find Full Text PDFThe conversion of urban montane forest resources into urban parks requires careful assessment to understand its impacts on plant diversity over time. This study aims to enhance urban biodiversity conservation strategies by analyzing how habitat type and park age affect woody plant diversity. We surveyed woody plant species in 60 sample plots across two different habitats (remnant forest vs.
View Article and Find Full Text PDFVehicles equipped with automated driving capabilities have shown potential to improve safety and operations. Advanced driver assistance systems (ADAS) and automated driving systems (ADS) have been widely developed to support vehicular automation. Although the studies on the injury severity outcomes that involve automated vehicles are ongoing, there is limited research investigating the difference between injury severity outcomes for the ADAS and ADS equipped vehicles.
View Article and Find Full Text PDFImportance: Exotropia and myopia are commonly coexistent. However, evidence is limited regarding atropine interventions for myopia control in children with myopia and intermittent exotropia (IXT).
Objective: To evaluate the efficacy and safety of 0.
Numerous studies have characterized the critical role of circular RNAs (circRNAs) as regulatory factors in the progression of multiple cancers. However, the biological functions of circRNAs and their underlying molecular mechanisms in the progression of uveal melanoma (UM) remain enigmatic. In this study, we identified a novel circRNA, , through re-analysis of UM microarray data and quantitative RT-PCR.
View Article and Find Full Text PDFHuman activities have strongly impacted the global climate, and during the last few decades the global average temperature has risen at a rate faster than at any time on record. High latitude lakes in the subarctic and arctic permafrost regions have particularly been vulnerable given the "Arctic amplification" phenomenon and acceleration in warming rate in the northern hemisphere (0.2-0.
View Article and Find Full Text PDFHydrogen sulfide (HS), a toxic gas abundant in natural gas fields and refineries, is currently being removed mainly via the Claus process. However, the emission of sulfur-containing pollutants is hard to be prevented and the hydrogen element is combined to water. Herein, we report an electron-mediated off-field electrocatalysis approach (OFEC) for complete splitting of HS into H and S under ambient conditions.
View Article and Find Full Text PDFLakes in taiga and tundra regions may be silently undergoing changes due to global warming. One of those changes is browning in lake color. The browning interacts with the carbon cycle, ecosystem dynamics, and water quality in freshwater systems.
View Article and Find Full Text PDFBackground: Coronavirus disease 2019 (COVID-19) and thrombosis are linked, but the biomolecular mechanism is unclear. We aimed to investigate the causal relationship between COVID-19 and thrombotic biomarkers.
Methods: We used two-sample Mendelian randomization (MR) to assess the effect of COVID-19 on 20 thrombotic biomarkers.
Cancer Rep (Hoboken)
February 2024
Background: Retinoblastoma (RB) is the most common prevalent intraocular malignancy among infants and children, particularly in underdeveloped countries. With advancements in genomics and transcriptomics, noncoding RNAs have been increasingly utilized to investigate the molecular pathology of diverse diseases.
Aims: This study aims to establish the competing endogenous RNAs network associated with RB, analyse the function of mRNAs and lncRNAs, and finds the relevant regulatory network.
The utilization of traffic conflict indicators is crucial for assessing traffic safety, especially when the crash data is unavailable. To identify traffic conflicts based on traffic flow characteristics across various traffic states, we propose a framework that utilizes unsupervised learning to automatically establish surrogate safety measures (SSM) thresholds. Different traffic states and corresponding transitions are identified with the three-phase traffic theory using high-resolution trajectory data.
View Article and Find Full Text PDFThis study aims to analyze the outcomes and measurements of randomized controlled trial(RCT) for traditional Chinese medicine(TCM) treatment of endometriosis(EM) and provide a basis for the building of the core outcome set(COS) of EM. The RCT for TCM treatment of EM was retrieved from medical literature databases with the time interval from inception to February 3, 2022. The Cochrane risk of bias assessment tool was employed to evaluate the risk of bias of the included RCT, and descriptive analyses of the extracted information were carried out.
View Article and Find Full Text PDFExploring the alterations in functional traits of urban remnant vegetation offers a more comprehensive perspective on plant assembly within the context of urbanization. While plant functional traits are influenced by both environmental gradients and the evolutionary history of plant species, the specific mechanisms by which urbanization mediates the combination of functional traits and the evolutionary history of remnant vegetation remain unclear. To examine the relationship between functional traits and phylogenies of remnant vegetation and urbanization, we classified the woody plant species surveyed in 72 sample plots in nine remnant forest patches in Guiyang, China, into four groups (urban, rural, middle and general groups) according to their location under different levels of urbanization and measured nine functional traits of these species.
View Article and Find Full Text PDFThe ChatGPT, a lite and conversational variant of Generative Pretrained Transformer 4 (GPT-4) developed by OpenAI, is one of the milestone Large Language Models (LLMs) with billions of parameters. LLMs have stirred up much interest among researchers and practitioners in their impressive skills in natural language processing tasks, which profoundly impact various fields. This paper mainly discusses the future applications of LLMs in dentistry.
View Article and Find Full Text PDFThe application of Computer Vision (CV) techniques massively stimulates microscopic traffic safety analysis from the perspective of traffic conflicts and near misses, which is usually measured using Surrogate Safety Measures (SSM). However, as video processing and traffic safety modeling are two separate research domains and few research have focused on systematically bridging the gap between them, it is necessary to provide transportation researchers and practitioners with corresponding guidance. With this aim in mind, this paper focuses on reviewing the applications of CV techniques in traffic safety modeling using SSM and suggesting the best way forward.
View Article and Find Full Text PDFTransl Vis Sci Technol
June 2023
Purpose: To explore associations of fundus tessellated density (FTD) and compare characteristics of different fundus tessellation (FT) distribution patterns, based on artificial intelligence technology using deep learning.
Methods: Comprehensive ocular examinations were conducted in 577 children aged 7 years old from a population-based cross-sectional study, including biometric measurement, refraction, optical coherence tomography angiography, and 45° nonmydriatic fundus photography. FTD was defined as the average exposed choroid area per unit area of the fundus, and obtained by artificial intelligence technology.
Objectives: Uveal melanoma (UVM), the leading type of intraocular malignant tumor in adults, has an aggressive course with poor prognoses, high mortality, and lacking effective therapeutic targets and prognostic markers. Annexins are well known as dysregulated and correlated with aggressiveness and prognosis of various cancers. However, little is known about the expression pattern of Annexins in UVM and their prognostic value.
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