MoVis: When 3D Object Detection is Like Human Monocular Vision.

Monocular 3D object detection has garnered significant attention for its outstanding cost effectiveness compared with multi-sensor systems. However, previous work mainly acquires object 3D properties in a heuristic way, with less emphasis on the cues between objects. Inspired by the mechanisms of monocular vision, we propose MoVis, an innovative 3D object detection framework that skillfully combines object hierarchy and color sequence cues.

CAV1 promotes epithelial-to-mesenchymal transition (EMT) and chronic renal allograft interstitial fibrosis by activating the ferroptosis pathway.

Background: Chronic allograft dysfunction (CAD) stands as a critical factor that limits the long-term viability of transplanted kidneys. Ferroptosis is an iron-dependent form of programmed cell death increasingly linked to chronic fibrosis. However, the mechanism by which ferroptosis contributes to the onset and progression of CAD remains unclear.

Rv2741 Promotes Mycobacterium Survival by Modulating Macrophage Function via the IL-1α-MAPK Axis.

One of the primary healthcare problems in the world today is tuberculosis (TB), a chronic infectious illness brought on by (). A distinct family of PE_PGRS proteins, encoded by the genome, has attracted more attention because of their involvement in immune evasion and bacterial pathogenicity. Nevertheless, the specific functions and mechanisms of action for the majority of PE_PGRS proteins remain largely unexplored.

Integrating single-cell sequencing and machine learning to uncover the role of mitophagy in subtyping and prognosis of esophageal cancer.

Globally, esophageal cancer stands as a prominent contributor to cancer-related fatalities, distinguished by its poor prognosis. Mitophagy has a significant impact on the process of cancer progression. This study investigated the prognostic significance of mitophagy-related genes (MRGs) in esophageal carcinoma (ESCA) to elucidate molecular subtypes.

Role of microvascular pericyte dysfunction in antibody-mediated rejection following kidney transplantation.

Objective: To investigate the role of microvascular pericyte dysfunction in antibody-mediated rejection (ABMR) of transplanted kidneys.

Methods: A total of 160 patients who underwent kidney transplantation in our hospital from 2004 to 2020 were enrolled, divided into 4 groups: ABMR group ( = 79), TCMR group ( = 20), mixed rejection group ( = 25) and control group ( = 36). Postoperative renal function indicators were compared, and immunohistochemical and immunofluorescence staining was performed on graft tissues and mice models using the pericyte marker PDGFR-β.

Association Between Liver Fibrosis and Risk of Incident Stroke and Mortality: A Large Prospective Cohort Study.

Background: There is a well-established relationship between liver conditions and cardiovascular diseases. However, uncertainty persists regarding the contribution of liver fibrosis to major stroke types including ischemic stroke, intracerebral hemorrhage, and subarachnoid hemorrhage at the population level.

Methods: In this large prospective cohort study, participants without previous stroke or coronary heart disease at baseline from the UK Biobank were included.

Diagnosis and treatment of hepatocellular carcinoma with pelvic metastasis expressing AFP: a case report.

This report presents the case of a 68-year-old female patient with hepatocellular carcinoma (HCC) who experienced persistently elevated alpha-fetoprotein (AFP) levels following resection of the primary liver tumor. The patient had previously undergone transcatheter arterial chemoembolization (TACE) and liver tumor resection, but postoperative AFP levels continued to rise, suggesting the possibility of extrahepatic metastasis. PET-CT scans revealed an irregular soft tissue mass in the recto-uterine pouch, which was later confirmed as a HCC metastasis through needle biopsy.

Predictors and lesion patterns of dysphagia and swallowing outcomes after acute intracerebral hemorrhage.

Background: Dysphagia is a common complication following intracerebral hemorrhage (ICH) and is associated with an increased risk of aspiration pneumonia and poor outcomes.

Objectives: This study aimed to explore associated lesion patterns and contributing factors of post-ICH dysphagia, and predict dysphagia outcomes following ICH.

Design: A multicenter, prospective study.

Predicting the risk of hematoma expansion in acute intracerebral hemorrhage: the GIVE score.

Background: Numerous noncontrast computed tomography (NCCT) markers have been reported and validated as effective predictors of hematoma expansion (HE). Our objective was to develop and validate a score based on NCCT markers and clinical characteristics to predict risk of HE in acute intracerebral hemorrhage (ICH) patients.

Methods: We prospectively collected spontaneous ICH patients at the First Affiliated Hospital of Chongqing Medical University to form the development cohort (n = 395) and at the Third Affiliated Hospital of Chongqing Medical University to establish the validation cohort (n = 139).

Electrophysiology-based screening identifies neuronal HtrA serine peptidase 2 (HTRA2) as a synaptic plasticity regulator participating in tauopathy.

Long-term potentiation (LTP) and long-term depression (LTD) are widely used to study synaptic plasticity. However, whether proteins regulating LTP and LTD are altered in cognitive disorders and contribute to disease onset remains to be determined. Herein, we induced LTP and LTD in the hippocampal CA3-CA1 Schaffer collateral pathway, respectively, and then performed proteomic analysis of the CA1 region.

Terpene mixtures and metabolic syndrome in the US general population: exploring the mediating role of insulin resistance.

Background: Terpenes have been shown to have an effect on metabolic status. However, it is unclear how they are associated with the metabolic syndrome (MetS) and whether insulin resistance (IR) mechanisms are involved.

Methods: This cross-sectional study included data from the National Health and Nutrition Examination Survey (2013-2014).

Microglial CD2AP deficiency exerts protection in an Alzheimer's disease model of amyloidosis.

Background: The CD2-associated protein (CD2AP) was initially identified in peripheral immune cells and regulates cytoskeleton and protein trafficking. Single nucleotide polymorphisms (SNPs) in the CD2AP gene have been associated with Alzheimer's disease (AD). However, the functional role of CD2AP, especially its role in microglia during AD onset, remains elusive.

Femtosecond Laser Introduced Cantilever Beam on Optical Fiber for Vibration Sensing.

An all-fiber vibration sensor based on the Fabry-Perot interferometer (FPI) is proposed and experimentally evaluated in this study. The sensor is fabricated by introducing a Fabry-Perot cavity to the single-mode fiber using femtosecond laser ablation. The cavity and the tail act together as a cantilever beam, which can be used as a vibration receiver.

Genome-Wide Identification and Expression Analysis of Carotenoid Cleavage Dioxygenase Genes in .

In the process of catalyzing carotenoids into various apocarotenoids and other derivatives, carotenoid cleavage dioxygenases (CCDs) play key roles. However, little information on CCDs has been reported in regard to . In this study, a total of 21 CCD genes were identified in the whole genome of , mainly distributed between five chromosomes.

Efficacy and cost-effectiveness analysis of flexible ureteroscopic lithotripsy with TFDS in the treatment of urolithiasis.

Background: At present, there is no effective drug to remove residual stones. Total flavonoids of desmodium styracifolium (TFDS) is an innovative traditional Chinese medicine listed in 2022, which can be used to treat ureteral calculi. This study was to explore the effectiveness and economic value of TFDS in the treatment of residual stones after flexible ureteroscopic lithotripsy (FURL).

Selection and optimization of biofilm carriers as high-effective microbial separator in microbial fuel cells.

Four biofilm carriers including pyrite, manganese ore, ceramsite, and polyurethane sponge were used to construct microbial separators (MSs), while their performance in dual-chamber microbial fuel cells (MFCs) was evaluated. Polyurethane sponge and pyrite were superior biofilm carriers for MSs. The dense biofilm on the polyurethane sponge provides MS with optimal barrier capacity against dissolved oxygen and chemical oxygen demand.

Exploring the molecular interactions between nephrolithiasis and carotid atherosclerosis: asporin as a potential biomarker.

Increasing evidence suggested nephrolithiasis has a close linkage with carotid atherosclerosis (CAS), with Randall's plaque (RP) being a precursor to kidney stones. Our study aimed to examine the crosstalk genes and potential molecular mechanisms between RP and CAS. We obtained microarray data for RP and CAS from the Gene Expression Omnibus (GEO) and used weighted gene co-expression network analysis (WGCNA) and differential gene expression (DEG) analysis to identify shared genes.

The complete chloroplast genome sequence of (Magnoliaceae).

is an evergreen garden plant with attractive and fragrant flowers. exhibits both interspecific and intraspecific phenotypic variability. However, the genetic diversity of has not been thoroughly investigated.

A novel Cdc42-YAP-fibronectin signaling axis regulates ameloblast differentiation during early enamel formation.

Enamel formation is a developmental event governed by intricate molecular signal pathways. Cdc42 is proven to regulate enamel development yet its underlying role and molecular mechanism in early amelogenesis remain elusive. The extracellular matrix of tooth germ basement membrane is critical for the regulation of ameloblast differentiation.

Inhibition of Candida albicans virulence by moscatin from Dendrobium nobile lindl.

Candida albicans infection poses a significant global health threat. It is imperative to exploit new antifungal agents against C. albicans infections without leading to drug resistance, so that these potential agents can complement or combine with current medications to effectively treat diseases caused by C.

Vapor Nucleation on Hybrid-Wetting Nanoconvex Surfaces: The Competition between Intrinsic Wettability and Topography.

Hybrid-wetting surfaces with hydrophilic spots reduced from the micrometer to nanometer scale have been confirmed to enhance vapor nucleation while simultaneously minimizing droplet pinning. Given that surface topography also plays a critical role in influencing nucleation characteristics, the effect of competition between intrinsic wettability and topography on nucleation remains unclear when both surface topography and hydrophilic regions approach the critical nucleation size. This work investigated vapor nucleation on two types of hybrid-wetting nanoconvex surfaces.