KRT14 is a promising prognostic biomarker of breast cancer related to immune infiltration.

Background: Breast cancer (BC) is the leading cancer among women globally, which has the highest incidence and mortality rate in over a hundred countries. This study was intended to discover a new prognostic biomarker, facilitating personalized treatment approaches.

Methods: RNA sequencing data from The Cancer Genome Atlas database and Gene Expression Omnibus database were utilized to download to evaluate expression levels and prognostic significance of Keratin 14 (KRT14).

An Underwater Polarization Imaging Technique Based on the Construction and Decomposition of the Low-Rank and Sparse Matrix in Stokes Space for Polarization State Imaging.

Traditional underwater polarization imaging methods can only provide clear degree of polarization (DOP) and intensity images of the object but cannot provide images of the polarization state of the object. This paper proposes a method to extract clear object information from turbid water in all four Stokes parameter (I, Q, U, and V) channels by using the full Stokes camera, enabling clear polarization state image reconstruction. The method utilizes multiple images from different angles to construct a low-rank and sparse matrix.

Apaf-1 is an evolutionarily conserved DNA sensor that switches the cell fate between apoptosis and inflammation.

Apoptotic protease activating factor 1 (Apaf-1) was traditionally defined as a scaffold protein in mammalian cells for assembling a caspase activation platform known as the 'apoptosome' after its binding to cytochrome c. Although Apaf-1 structurally resembles animal NOD-like receptor (NLR) and plant resistance (R) proteins, whether it is directly involved in innate immunity is still largely unknown. Here, we found that Apaf-1-like molecules from lancelets, fruit flies, mice, and humans have conserved DNA sensing functionality.

The promoting effect of Balanus albicostatus cement protein 19k (Balcp19k) on wound healing by regulating fibroblast migration and relieving early-stage inflammation responses.

The high incidence of skin wounds (e.g., burns, diabetic ulcers, venous ulcers, pressure sores, and radiation injuries) remains a significant challenge in clinical settings.

Radioimmunotherapy combating biofilm-associated infection .

Background: Addressing prosthetic joint infections poses a significant challenge within orthopedic surgery, marked by elevated morbidity and mortality rates. The presence of biofilms and infections attributed to () further complicates the scenario.

Objective: To investigate the potential of radioimmunotherapy as an innovative intervention to tackle biofilm-associated infections.

Superior flame retardancy, thermal insulation, and mechanical properties of konjac glucomannan/sodium alginate biomass aerogel modified by supramolecular assembled phytic acid-melamine nanosheet.

The development of biomass-based eco-friendly aerogel with superior flame retardancy, thermal insulation, and mechanical properties at the same time has long been a tough challenge. In this study, the polysaccharide-based aerogels composed of konjac glucomannan, sodium alginate, and supramolecular assembled melamine phytate (MPA) nanosheets were successfully fabricated through the freeze-drying method. Owing to the excellent charcoal-forming and non-combustible gas-releasing effect of MPA nanosheets, the thermal stability and flame retardancy properties of the aerogels were both significantly enhanced, with the highest limiting oxygen index value reaching 42.

EPDR1 promotes PD-L1 expression and tumor immune evasion by inhibiting TRIM21-dependent ubiquitylation of IkappaB kinase-β.

While immune checkpoint blockade (ICB) has shown promise for clinical cancer therapy, its efficacy has only been observed in a limited subset of patients and the underlying mechanisms regulating innate and acquired resistance to ICB of tumor cells remain poorly understood. Here, we identified ependymin-related protein 1 (EPDR1) as an important tumor-intrinsic regulator of PD-L1 expression and tumor immune evasion. Aberrant expression of EPDR1 in hepatocellular carcinoma is associated with immunosuppression.

The myokine CCL5 recruits subcutaneous preadipocytes and promotes intramuscular fat deposition in obese mice.

Intramuscular fat (IMF) refers to the lipid stored in skeletal muscle tissue. The number and size of intramuscular adipocytes are the primary factors that regulate IMF content. Intramuscular adipocytes can be derived from either in situ or ectopic migration.

HKDC1 promotes tumor immune evasion in hepatocellular carcinoma by coupling cytoskeleton to STAT1 activation and PD-L1 expression.

Immune checkpoint blockade (ICB) has shown considerable promise for treating various malignancies, but only a subset of cancer patients benefit from immune checkpoint inhibitor therapy because of immune evasion and immune-related adverse events (irAEs). The mechanisms underlying how tumor cells regulate immune cell response remain largely unknown. Here we show that hexokinase domain component 1 (HKDC1) promotes tumor immune evasion in a CD8 T cell-dependent manner by activating STAT1/PD-L1 in tumor cells.

Electropolymerization of Preferred-Oriented Conjugated Microporous Polymer Films for Enhanced Fluorescent Sensing.

High-quality conjugated microporous polymer (CMP) films with orientation and controlled structure are extremely desired for applications. Here, we report the effective construction of CMP 3D composite films (pZn/PTPCz) with a controlled porosity structure and preferred orientation using the template-assisted electropolymerization (EP) approach for the first time. The structure of pZn/PTPCz composite thin films and nitrophenol sensing performance were thoroughly studied.

Novel supramolecular deep eutectic solvent pretreatment for obtaining fluorescent lignin and promoting biomass pyrolytic saccharification.

In this study, β-CD was used as a receptor to prepare three novel SDES, which were used to pretreat corn stalks for obtaining fluorescent lignin and promoting biomass pyrolytic saccharification. It was found that GA-residue had a high cellulose retention ratio (94.63%) and the highest lignin removal ratio (61.

Safety and efficacy of thoracic endovascular aortic repair for acute Stanford type B aortic dissection with retrograde type A intramural hematoma.

Objective: The aim of this study was to evaluate safety and efficacy of thoracic endovascular aortic repair (TEVAR) for acute Stanford type B aortic dissection (TBAD) with retrograde type A intramural hematoma (TAIMH).

Methods: Patients with acute TBAD with retrograde TAIMH treated with TEVAR between January 1, 2014, to March 31, 2022, were retrospectively reviewed. Aortic diameter and distance were measured using the 3D Slicer image computing platform.

Mitochondria-localized cGAS suppresses ferroptosis to promote cancer progression.

A well-established role of cyclic GMP-AMP synthase (cGAS) is the recognition of cytosolic DNA, which is linked to the activation of host defense programs against pathogens via stimulator of interferon genes (STING)-dependent innate immune response. Recent advance has also revealed that cGAS may be involved in several noninfectious contexts by localizing to subcellular compartments other than the cytosol. However, the subcellular localization and function of cGAS in different biological conditions is unclear; in particular, its role in cancer progression remains poorly understood.

Integration of Neuroscience and Entrepreneurship: A Systematic Review and Bibliometric Analysis.

In this study, we investigated the integration between neuroscience and entrepreneurship. First, we explored the concept of neuroentrepreneurship and the investigation of neuroentrepreneurship using scientific research methods. Second, we constructed a road map for entrepreneurial researchers interested in conducting neuroentrepreneurship-related research.

Putative MicroRNA-mRNA Networks Upon Mdfi Overexpression in C2C12 Cell Differentiation and Muscle Fiber Type Transformation.

Mdfi, an inhibitor of myogenic regulatory factors, is involved in myoblast myogenic development and muscle fiber type transformation. However, the regulatory network of Mdfi regulating myoblasts has not been revealed. In this study, we performed microRNAs (miRNAs)-seq on Mdfi overexpression (Mdfi-OE) and wild-type (WT) C2C12 cells to establish the regulatory networks.

Mdfi Promotes C2C12 Cell Differentiation and Positively Modulates Fast-to-Slow-Twitch Muscle Fiber Transformation.

Muscle development requires myoblast differentiation and muscle fiber formation. Myod family inhibitor (Mdfi) inhibits myogenic regulatory factors in NIH3T3 cells, but how Mdfi regulates myoblast myogenic development is still unclear. In the present study, we constructed an Mdfi-overexpression (Mdfi-OE) C2C12 cell line by the CRISPR/Cas9 system and performed RNA-seq on Mdfi-OE and wild-type (WT) C2C12 cells.

MiR-92b-3p inhibits proliferation and migration of C2C12 cells.

Skeletal muscle, a critical component of the mammalian body, is essential for normal body movement. miRNAs are well documented in gene post-transcription regulation in many biological processes, including muscle development and maintenance. miR-92b-3p, which is often associated with tumorigenesis, has never been explored in myoblast development.

The efficacy of bidirectional barbed sutures for incision closure in total knee replacement: A protocol of randomized controlled trial.

Background: Barbed suture is a novel type of suture introduced in different surgical specialties. Nevertheless, its effect in total knee replacement is still unclear in terms of wound complications and cost effectiveness. The purpose of the present work is to evaluate the safety and efficacy of bidirectional barbed suture in reducing postoperative wound complications in the patients undergoing total knee replacement.