Background: Early diagnosis and treatment of mental illnesses is hampered by the lack of reliable markers. This study used machine learning models to uncover diagnostic and risk prediction markers for eating disorders (EDs), major depressive disorder (MDD), and alcohol use disorder (AUD).
Methods: Case-control samples (aged 18-25 years), including participants with Anorexia Nervosa (AN), Bulimia Nervosa (BN), MDD, AUD, and matched controls, were used for diagnostic classification.
Tuberculosis (TB), primarily caused by () and (), remains the leading cause of death from a single infectious agent globally. Intracellular survival is crucial for their virulence; yet, the underlying mechanisms are not fully understood. This study aimed to demonstrate the significance of a previously unannotated bovine gene ENSBTAG00000011305 in intracellular survival.
View Article and Find Full Text PDFContrast-induced acute kidney injury (CI-AKI) has emerged as a global public health concern, ranking as the third most prevalent cause of hospital-acquired acute kidney injury, which is related to adverse outcomes. However, its precise pathogenesis remains elusive. Consequently, researchers are dedicated to uncovering CI-AKI's pathophysiology and signaling pathways, including inflammation, oxidative stress, apoptosis, and ferroptosis, to improve prevention and treatment.
View Article and Find Full Text PDFThe limitations of deep neural networks in continuous learning stem from oversimplifying the complexities of biological neural circuits, often neglecting the dynamic balance between memory stability and learning plasticity. In this study, artificial synaptic devices enhanced with graphene quantum dots (GQDs) that exhibit metaplasticity is introduced, a higher-order form of synaptic plasticity that facilitates the dynamic regulation of memory and learning processes similar to those observed in biological systems. The GQDs-assisted devices utilize interface-mediated modifications in asymmetric conductive pathways, replicating classical synaptic plasticity mechanisms.
View Article and Find Full Text PDFN-(1,3-Dimethylbutyl)-'-phenyl-1,4-phenylenediamine (6PPD) and its oxidation product 6PPD-quinone (6PPDQ) showed different acute toxicities and bioaccumulation potencies in fish. In this study, we compared the thyroid disrupting effects of 6PPD and 6PPDQ through , , and assays. Interestingly, although 6PPD and 6PPDQ showed similar docking affinities with thyroid hormone receptor (TR) isoforms and GH3 cell inhibition effects, the thyroid signaling pathway, eye development, phototactic behaviors, and cell density in the retinal layer in the larval zebrafish were significantly affected only following 6PPD exposure.
View Article and Find Full Text PDFThis paper reports a 3.8 µm pulse burst self-optical parametric oscillator (SOPO) employing the Nd:MgO:PPLN crystal, achieving programmable mid-infrared pulse burst output based on step-active Q-switching technology. Building on the intracavity optical parametric oscillator (IOPO) theory, a theoretical model for the step-active Q-switched self-optical parametric oscillator is developed by introducing idler photon and step loss terms.
View Article and Find Full Text PDFWe present a 3.8 µm self-optical parametric oscillator (SOPO) pumped by a pulsed laser diode (LD) based on only one Nd:MgO:PPLN crystal. The problem of heat accumulation in Nd:MgO:PPLN crystals caused by high-power laser pumping is significantly optimized.
View Article and Find Full Text PDFThe increasing sophistication of cybersecurity threats, driven by the proliferation of big data and the Internet of Things (IoT), necessitates the development of advanced real-time intrusion detection systems (IDSs). In this study, we present a novel approach that integrates NiO-doped WO/ZnO bilayer self-rectifying memristors (SRMs) within a reservoir computing (RC) framework for IDS applications. The proposed crossbar array architecture exploits the exceptional dynamic properties of SRMs, achieving a classification accuracy of 93.
View Article and Find Full Text PDFMicroplastics (MPs) in subsurface environments are migratory and can carry heavy metals, increasing the extent of MP and heavy metal pollution. This study used quartz sand-filled column experiments to investigate the adsorption and cotransport behaviours of PS-MPs, O, UV-aged PS-MPs, and Cu at different MP concentrations, ionic strengths, and ionic valences in a saturated porous medium. The results showed that when MPs migrate alone in the absence of an ionic background, higher concentrations have increased mobility.
View Article and Find Full Text PDFPlastic disposal has become a challenge due to its challenging degradability, and plastics recycling is one of the ideal methods. The utilization of recycled plastic in building materials has been widely researched as a possible way to store plastics permanently. An investigation on the modification and incorporation of polyethylene terephthalates (PET) on fresh and hardened properties of mortar composites (MCs) is performed in the study.
View Article and Find Full Text PDFInsulin-like peptides (ILPs) act as crucial reproductive neuropeptides in insects, regulating insect reproduction through the insulin signaling pathway (ISP). Our previous studies have found that the sublethal concentrations (LC and LC) of lambda-cyhalothrin (λCy) could induce severe reproductive toxicity in the lacewing, Chrysoperla sinica (Tjeder), but the toxicological mechanism remains unclear. This study discovered that λCy could inhibit CsILP transcription, leading to a decrease in insulin content and downregulation of C.
View Article and Find Full Text PDFAs a kind of promising oxygen evolution reaction (OER) catalysts, metal-organic frameworks (MOF) are often constrained by their inherent poor electroconductivity and structural instability. In this study, we developed a mono-dispersed zeolitic imidazolate framework-67@cuprous oxide (ZIF-67@CuO) core-shell catalyst via in-situ growth method for highly efficient alkaline OER. The ZIF-67@CuO shows an excellent OER activity with a low overpotential of 254 mV at 10 mA cm and Tafel slope of 87.
View Article and Find Full Text PDFOvercoming the trade-off between the graphitization of the carbon substrate and enhanced electronic metal-support interaction (EMSI) and intrinsic activity of Pt-C catalysts remains a major challenge for ensuring the durable operation of energy conversion devices. This article presents a hybrid catalyst consisting of PtFe nanoparticles and single Pt and Fe atoms supported on N-doped carbon (PtFe@PtFe-N-C), which exhibits improved activities in hydrogen evolution and oxygen reduction reactions (HER and ORR, respectively) and has excellent durability owing to the high graphitization, rich edge defects, and porosity of the carbon in PtFe@PtFe-N-C, as well as strong EMSI between the PtFe nanoparticles and edge-defective carbon embedded with Pt and Fe atoms. According to theoretical calculations, the strong EMSI optimizes the H* adsorption-desorption and facilitates the adsorption OOH*, accelerating the HER and ORR processes.
View Article and Find Full Text PDFT cells play a critical and irreplaceable role in maintaining overall health. However, their functions undergo alterations as individuals age. It is of utmost importance to comprehend the specific characteristics of T-cell aging, as this knowledge is crucial for gaining deeper insights into the pathogenesis of aging-related diseases and developing effective therapeutic strategies.
View Article and Find Full Text PDFBacterial infection is the primary cause of delayed wound healing. Infected wounds suffer from a series of harmful factors in the harsh wound microenvironment (WME), greatly damaging their potential for tissue regeneration. Herein, a novel probiotic biofilm-based antibacterial strategy is proposed through experimentation.
View Article and Find Full Text PDFUrological malignancy (UM) is among the leading threats to health care worldwide. Recent years have seen much investment in fundamental UM research, including mechanistic investigation, early diagnosis, immunotherapy, and nanomedicine. However, the results are not fully satisfactory.
View Article and Find Full Text PDFAnn Clin Transl Neurol
September 2024
Objectives: This study aims to investigate whether alterations in white matter topological networks are associated with focal to bilateral tonic-clonic seizures (FBTCS) in temporal lobe epilepsy (TLE). Additionally, we investigated the variables contributing to memory impairment in TLE.
Methods: This cross-sectional study included 88 unilateral people with TLE (45 left/43 right), and 42 healthy controls.
Background: Oral Mucositis (OM) is a common and highly symptomatic complication of cancer therapy that affects patient function and quality of life. Jingzhi Niuhuangjiedu Tablet (JNT) is derived from the famous Chinese herbal formulas Huanglian Jiedu and Fangfeng Tongsheng decoctions, which have been widely used to treat heat toxin syndrome diseases, such as acute pharyngitis, periodontitis, oral ulcers, and oral mucositis (OM), but the underlying mechanism remains unclear.
Objectives: This study validated the efficacy and explored the potential mechanisms of JNT in the treatment of OM by integrating network pharmacological analyses and experimental verification.