Evaluating the combined estrogenic effects of plant growth regulators electrochemical and E-Screen methods.

The study shows that plant growth regulators (PGRs) have estrogenic effects, which may disrupt the normal physiological functions of endogenous estrogen in organisms. This study used electrochemical methods to investigate the electrochemical behavior and estrogenic effects of PGRs gibberellic acid (GA), ethylene (ETH), and naphthalene acetic acid (NAA) on estrogen-free human breast cancer cells (MCF-7) cells when exposed individually or in combination. The results indicate that GA, ETH, and NAA, whether used alone or in combination, exhibit estrogenic effects on MCF-7 cells.

Adolescent exposure to tris(1,3-dichloro-2-propyl) phosphate (TCPP) induces reproductive toxicity in zebrafish through hypothalamic-pituitary-gonadal axis disruption.

Tris(1,3-dichloro-2-propyl) phosphate (TCPP), a prevalent organophosphorus flame retardant in aquatic environments, has raised significant concerns regarding its ecological risks. This study aims to explore the impacts of TCPP on the reproductive functions of zebrafish and delineate its gender-related toxic mechanisms. By assessing the effects on zebrafish of 10 mg/L TCPP exposure from 30 to 120 days post-fertilization (dpf), we thoroughly evaluated the reproductive capability and endocrine system alterations.

Lindqvist-type Polyoxometalates Act as Anti-breast Cancer Drugs via Mitophagy-induced Apoptosis.

Objective: Lindqvist-type polyoxometalates (POMs) exhibit potential antitumor activities. This study aimed to examine the effects of Lindqvist-type POMs against breast cancer and the underlying mechanism.

Methods: Using different cancer cell lines, the present study evaluated the antitumor activities of POM analogues that were modified at the body skeleton based on molybdenum-vanadium-centered negative oxygen ion polycondensations with different side strains.

Skin Electrodes Based on TPU Fiber Scaffolds with Conductive Nanocomposites with Stretchability, Breathability, and Washability.

In the context of an aging population and escalating work pressures, cardiovascular diseases pose increasing health risks. Electrocardiogram (ECG) monitoring presents a preventive tool, but conventional devices often compromise comfort. This study proposes an approach using Ag NW/TPU composites for flexible and breathable epidermal electronics.

Tris-Functionalized Polyoxotungstovanadate-Mediated Antitumor Efficacy Involves Multiple Cell Death Pathways.

Polyoxometalates (POMs) are promising inorganic drug candidates for cancer chemotherapy. They are becoming attractive because of their easy accessibility and low cost. Herein, we report the synthesis and antitumor activity studies of four Lindqvist-type POMs with mixed-addenda atoms Na[VWO{(OCH)CR}] (R=-CHOH, -CH, -CHCH) and (BuN)[VW{(OCH)CHOOCCHCH}].

Exposure risk and emergency evacuation modeling of toxic gas leakage in urban areas under the influence of multiple meteorological factors.

Frequent toxic gas leakage accidents in urban environments cannot be timely controlled and often cause great harm due to the many factors affecting gas diffusion. In this study, based on the coupling method of the Weather Research and Forecasting Model (WRF) and the open source OpenFOAM software platform, the chlorine gas diffusion process at different temperatures, wind speeds, and wind directions in a chemical laboratory and nearby urban areas in Beijing was studied numerically. A dose-response model was used to calculate chlorine lethality and assess exposure risk at the pedestrian level.

Induction of lipid metabolism dysfunction, oxidative stress and inflammation response by tris(1-chloro-2-propyl)phosphate in larval/adult zebrafish.

As an important organophosphate flame retardant, tris(1-chloro-2-propyl)phosphate (TCPP) is ubiquitous in the environment leading to inevitable human exposure. However, there is a paucity of information regarding its acute/chronic effects on obesity, lipid homeostasis, and hepatocellular carcinoma, especially regarding the underlying molecular mechanisms in humans. Herein, we investigated the effects of TCPP exposure (5-25 mg/L) on lipid homeostasis in larval and adult zebrafish (Danio rerio).

Alternation of supragingival microbiome in patients with cirrhosis of different Child-Pugh scores.

Objectives: The aim of this study was to analyze the differences in the taxonomy and functions of oral microbiome between patients with and without cirrhosis.

Materials And Methods: In this study, V4-16S rDNA amplicon sequencing was used to compare the difference of supragingival microbiome in 42 patients and 12 healthy individuals.

Results: Overall, 3,223,529 clean reads were generated, with an average of 59,694 ± 1,548 clean reads per sample.

Gas-Sensing Properties of the SiC Monolayer and Bilayer: A Density Functional Theory Study.

Using density functional theory calculations, the adsorption of gaseous molecules (NO, NO, NH, SO, CO, HCN, O, H, N, CO, and HO) on the graphitic SiC monolayer and bilayer has been investigated to explore the possibilities in gas sensors for NO, NO, and NH detection. The strong adsorption of NO and SO on the SiC monolayer precludes its applications in nitride gas sensors. The nitride gases (NO, NO, and NH) are chemisorbed on the SiC bilayer with moderate adsorption energies and apparent charge transfer, while the other molecules are all physisorbed.

SiBN monolayers as promising candidates for hydrogen storage.

Hydrogen storage properties of the pure Si2BN monolayer were studied using density functional theory calculations. The interaction of H2 molecules with the Si2BN monolayer is weak and of electrostatic nature. The average hydrogen adsorption energies are within the ideal range of practical applications (0.

[Comparison of flavonoids content in huangqi gnizhi wuwu tang of different dosages by uniform design method].

Objective: To determine the content of flavonoids in huangqi guizhi wuwu tang (HQGZWWT) of different dosages by uniform design method and analyze their difference for clinical application.

Methods: The uniform design set five factors and 11 levels to explore the content of flavonoids. The results were analyzed by computer with the method of multiple regression analysis.