Mechanism of Vaginal Epithelial Cell Pyroptosis Induced by the NLRP3 Inflammasome in Vulvovaginal Candidiasis.

Problem: Vulvovaginal candidiasis (VVC) is a common mucosal fungal infection, and Candida albicans is the main causative agent. The NLRP3 inflammasome plays an important role in VVC, but the underlying mechanism is unknown.

Method Of Study: Vaginal epithelial cells were divided into three groups: control, C.

The electric field cavity array effect of 2D nano-sieves.

For the upsurge of high breakdown strength ([Formula: see text]), efficiency ([Formula: see text]), and discharge energy density ([Formula: see text]) of next-generation dielectrics, nanocomposites are the most promising candidates. However, the skillful regulation and application of nano-dielectrics have not been realized so far, because the mechanism of enhanced properties is still not explicitly apprehended. Here, we show that the electric field cavity array in the outer interface of nanosieve-substrate could modulate the potential distribution array and promote the flow of free charges to the hole, which works together with the intrinsic defect traps of active CoO surface to trap and absorb high-energy carriers.

Surface Reconstruction on Electro-Spun PVA/PVP Nanofibers by Water Evaporation.

Tailoring the secondary surface morphology of electro-spun nanofibers has been highly desired, as such delicate structures equip nanofibers with distinct functions. Here, we report a simple strategy to directly reconstruct the surface of polyvinyl alcohol/polyvinylpyrrolidone (PVA/PVP) nanofibers by water evaporation. The roughness and diameter of the nanofibers depend on the temperature during vacuum drying.