Publications by authors named "Zihui Geng"
Ethnopharmacological Relevance: Fuzi-Lizhong pill (FLP) is a well-validated traditional Chinese medicine (TCM) formula that has long been used in China for gastrointestinal disease and adjunctive therapy for depression. In our previous study, we reported that the principal herb of FLP, Aconitum carmichaelii Debx. (Fuzi), exhibits antidepressant-like effects.
View Article and Find Full Text PDFKruppel-like factor 4 (Klf4) is a transcription factor that is involved in neuronal regeneration and the development of glutamatergic systems. However, it is unknown whether Klf4 is involved in acute seizure. To investigate the potential role of Klf4 in pentylenetetrazol (PTZ)-induced seizure, western blotting, immunofluorescence, behaviour test and electrophysiology were conducted in this study.
View Article and Find Full Text PDFRate dependence of early afterdepolarizations in the His-Purkinje system: A simulation study.
Comput Methods Programs Biomed
April 2022
Article Synopsis
- The study investigates how early afterdepolarizations (EADs) in the His-Purkinje system are influenced by the heart rate and their subsequent effect on ventricular electrical activities.
- Using simulation models, researchers analyzed the conditions under which EADs occur, revealing an association with stimulation cycle lengths.
- Key findings indicate that variations in a subcellular factor called x-gate contribute to EAD inconsistencies, which may cause conduction blocks, especially at slower heart rates.