MSCs overexpressing GDNF restores brain structure and neurological function in rats with intracerebral hemorrhage.

Mesenchymal stem cells (MSCs) have been applied in transplantation to treat intracerebral hemorrhage (ICH) but with limited efficacy. Accumulated evidence has shown that glial cell-derived neurotrophic factor (GDNF) plays a crucial part in neuronal protection and functional recovery of the brain after ICH; however, GDNF has difficulty crossing the blood-brain barrier, which limits its application. In this study, we investigated the influences of MSCs overexpressing GDNF (MSCs/GDNF) on the brain structure as well as gait of rats after ICH and explored the possible mechanisms.

Evaluating the effects of policies on building construction waste management: a hybrid dynamic approach.

The construction industry, as a vital pillar of a country's economy, generates a significant amount of construction waste, which places a tremendous burden on the environment and society. Although previous studies have explored the impact of policies on construction waste management, there is a lack of a simulation model that can be easily used, taking into account the dynamic nature, generality, and practicability of the model. To fill this gap, a hybrid dynamics model of construction waste management system is developed using agent-based modeling, system dynamics, perceived value, and experienced weighted attraction.

Decreased adhesion and improved biocompatibility on tetracycline-loaded TiO nanotubes: an in vitro study.

Background: Titanium dioxide (TiO) nanotubes are often used as carriers for loading materials such as drugs, proteins, and growth factors.

Materials And Methods: In this study, we loaded tetracycline onto TiO nanotubes to demonstrate its antibacterial properties and biocompatibility. The two-layered anodic TiO nanotubes with a honeycomb-like porous structure were fabricated by using a two-step anodization, and they were loaded with tetracycline by using a simplified lyophilization method and vacuum drying.

[TiO₂nanotubes functionalized with recombinant human bone morphogenetic protein-2 enhance biological activity in vitro].

Objective: To investigate the effect of TiO₂nanotube arrays covalently modified by recombinant human bone morphogenetic protein- 2(rhBMP- 2) on the early bioactivity of mesenchymal stem cells (MSC) in vitro and to provide experimental evidence for the biochemical modification of titanium implants.

Methods: In the experiment group, double titanium nanotube arrays were prepared by anodization, and were chemically grafted with rhBMP- 2. Mechanically polished pure titanium was used as blank control group, and titanium dioxide nanotubes was used as negative control A group, and titanium dioxide nanotubes + carbonyldiimidazole as negative control B group.