Publications by authors named "Zihuan Liu"

Article Synopsis
  • - BioPred is an R package designed for subgroup and biomarker analysis in precision medicine, utilizing advanced techniques like Extreme Gradient Boosting (XGBoost).
  • - It helps in optimizing individualized treatment rules and identifying predictive biomarkers, also offering importance rankings for these biomarkers.
  • - The package includes graphical plots for biomarker analysis and is available for download on CRAN and GitHub.
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Article Synopsis
  • The European LeukemiaNet (ELN) classification systems for acute myeloid leukemia (AML) are based on chemotherapy responses and may not effectively predict outcomes for older patients receiving venetoclax-azacitidine.
  • A pooled analysis from the phase 3 VIALE-A trial revealed that most patients were classified with adverse-risk AML, yet these classifications did not correlate well with survival outcomes for those treated with venetoclax-azacitidine.
  • New molecular signatures based on mutations in TP53, FLT3-ITD, NRAS, and KRAS identified three distinct patient benefit groups, each with significantly different median overall survival times.
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Neuroimaging studies often involve predicting a scalar outcome from an array of images collectively called tensor. The use of magnetic resonance imaging (MRI) provides a unique opportunity to investigate the structures of the brain. To learn the association between MRI images and human intelligence, we formulate a scalar-on-image quantile regression framework.

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The majority of reported measurements on high intensity ultrasound beams in air are below 40 kHz and performed on standing waves inside of a guide. Here, experimental characterization of high intensity progressive and divergent sound beams in air at 300 kHz are presented. Measurements in this frequency range are challenging.

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Analysis of host genetic components provides insights into the susceptibility and response to viral infection such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19). To reveal genetic determinants of susceptibility to COVID-19 related mortality, we train a deep learning model to identify groups of genetic variants and their interactions that contribute to the COVID-19 related mortality risk using the UK Biobank data (28,097 affected cases and 1656 deaths). We refer to such groups of variants as super variants.

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We consider the problem of nonparametric classification from a high-dimensional input vector (small n large p problem). To handle the high-dimensional feature space, we propose a random projection (RP) of the feature space followed by training of a neural network (NN) on the compressed feature space. Unlike regularization techniques (lasso, ridge, etc.

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Background: The transition from mild cognitive impairment (MCI) to dementia is of great interest to clinical research on Alzheimer's disease and related dementias. This phenomenon also serves as a valuable data source for quantitative methodological researchers developing new approaches for classification. However, the growth of machine learning (ML) approaches for classification may falsely lead many clinical researchers to underestimate the value of logistic regression (LR), which often demonstrates classification accuracy equivalent or superior to other ML methods.

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