Publications by authors named "Zihuai Huang"
Multiterritory perforator flap survival is commonly applied in surgical tissue reconstructions and covering of large skin defects. However, multiple risk factors such as ischemia, reperfusion injury, and apoptosis after reconstructive surgeries cause necrosis in distal parts with outcomes ranging from poor aesthetic appearance to reconstructive failure. A few studies have reported that sitagliptin (Sit) promotes angiogenesis and inhibits apoptosis.
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- Random-pattern flap necrosis poses a significant challenge in plastic surgery, prompting research into potential treatments like Nobiletin (NOB), a flavonoid with known beneficial properties.
- In an experiment with rats, researchers compared a control group to one treated with NOB, finding that the treated group had a larger area of viable flap tissue after seven days.
- The study concluded that NOB enhances survival of random skin flaps by reducing oxidative stress, improving blood flow, and demonstrating anti-inflammatory effects.
Article Synopsis
- Random-pattern skin flaps are crucial in reconstructive surgery, but complications like necrosis are common post-surgery.
- This study explores the effects of trehalose, an autophagy activator, in improving skin flap viability, showing it enhances blood flow, reduces edema, and supports tissue health.
- Trehalose boosts autophagy through specific signaling pathways, leading to increased angiogenesis, reduced oxidative stress, and decreased cell death, ultimately improving flap survival.
Article Synopsis
- Endothelial progenitor cells (EPCs) are important for tissue repair and were tested for their ability to enhance flap survival in a rabbit model.* -
- In the study, rabbits were split into three groups: sham, control, and EPC transplantation; flap survival and blood flow were assessed post-surgery.* -
- Results showed that the EPC group had a significantly higher flap survival rate (58.4%) compared to the control group (4.8%), along with improved microvessel density and elevated levels of eNOs and VEGF.*
Effects of pedicle torsion on dynamic perforasome survival in a multiterritory perforator flap model: An experimental study.
J Plast Reconstr Aesthet Surg
February 2019
Background: Necrosis of propeller flaps is a problem in clinical practice. This study was performed to investigate the effects of pedicle torsion on dynamic perforasome survival using a multiterritory perforator flap model in rats.
Methods: Intercostal artery perforator flaps (IC flaps) containing two adjacent dynamic perforasomes were applied to both sides of the dorsum in 15 rats.