Light-Driven Ionic and Molecular Transport through Atomically Thin Single Nanopores in MoS/WS Heterobilayers.

Nanofluidic ionic and molecular transport through atomically thin nanopore membranes attracts broad research interest from both scientific and industrial communities for environmental, healthcare, and energy-related technologies. To mimic the biological ion pumping functions, recently, light-induced and quantum effect-facilitated charge separation in heterogeneous 2D-material assemblies is proposed as the fourth type of driving force to achieve active and noninvasive transport of ionic species through synthetic membrane materials. However, to date, engineering versatile van der Waals heterostructures into 2D nanopore membranes remains largely unexplored.

Long-term efficacy and adverse effects of cannabidiol in adjuvant treatment of drug-resistant epilepsy: a systematic review and meta-analysis.

Background: Epilepsy is one of the most common chronic brain diseases. Almost one-third of patients have drug-resistant epilepsy (DRE). Cannabidiol is being considered as a potential novel drug for treating DRE.

Mendelian randomization reveals no causal relationship between COVID-19 susceptibility, hospitalization, or severity and epilepsy.

Objective: Observational studies have shown an association between COVID-19 and epilepsy. However, causality remains unproven. This study aimed to investigate the causative effect of genetically predicted COVID-19 phenotypes on epilepsy risk using a two-sample Mendelian randomization (MR) analysis.

The therapeutic effects of lacosamide on epilepsy-associated comorbidities.

Epilepsy is a chronic neurological disorder associated with severe social and psychological effects, and most epilepsy patients often report at least one comorbidity. Accumulating evidence have suggested that lacosamide, a new generation of anti-seizure medications, may exhibit efficacy in the management of both epilepsy and its related comorbidities. Therefore, this narrative review aimed to elucidate the recent advancements regarding the therapeutic role of lacosamide in epilepsy-associated comorbidities.

Sensitive electrochemical sensor based on poly(l-glutamic acid)/graphene oxide composite material for simultaneous detection of heavy metal ions.

Heavy metal pollution can be toxic to humans and wildlife, thus it is of great significance to develop rapid and sensitive methods to detect heavy metal ions. Here, a novel type of electrochemical sensor for the simultaneous detection of heavy metal ions has been prepared by using poly(l-glutamic acid) (PGA) and graphene oxide (GO) composite materials to modify the glassy carbon electrode (GCE). Due to the good binding properties of poly(l-glutamic acid) (PGA) for the heavy metal ions (such as Cu, Cd, and Hg) as well as good electron conductivity of graphene oxide (GO), the heavy metal ions, Cu, Cd, and Hg in aqueous solution can be accurately detected by using differential pulse anodic stripping voltammetry method (DPASV).

Three-dimensional characterization and distribution of fabrication defects in bilayered lithium disilicate glass-ceramic molar crowns.

Objective: To investigate and characterize the distribution of fabrication defects in bilayered lithium disilicate glass-ceramic (LDG) crowns using micro-CT and 3D reconstruction.

Methods: Ten standardized molar crowns (IPS e.max Press; Ivoclar Vivadent) were fabricated by heat-pressing on a core and subsequent manual veneering.