A NiP/NiMoO nanocone electrocatalyst for efficient hydrogen evolution: tip-enhanced local electric field effect.

The sluggish kinetics of the hydrogen evolution reaction (HER) result in a high overpotential in alkaline solutions. A high-curvature metal oxide heterostructure can effectively boost the electrocatalytic HER by leveraging the tip-enhanced local electric field effect. Herein, NiP/NiMoO nanocones were synthesised on a nickel foam (NF) substrate by etching a metal-organic framework template.

Connexin 43 Deficiency Confers Resistance to Immunotherapy in Lung Cancer via Inhibition of the Cyclic GMP-AMP Synthase-Stimulator of Interferon Genes Pathway.

Immune checkpoint inhibitors (ICIs), especially PD-1 inhibitors, are among the first-line therapeutic drugs for the treatment of advanced non-small cell lung cancer (NSCLC). However, most patients are not sensitive to PD-1 inhibitors, and prolonged exposure can lead to acquired resistance. Thus, it is urgent to elucidate the mechanism underlying the resistance of NSCLC to ICIs.

KCNN1 promotes proliferation and metastasis of breast cancer via ERLIN2-mediated stabilization and K63-dependent ubiquitination of Cyclin B1.

Potassium Calcium-Activated Channel Subfamily N1 (KCNN1), an integral membrane protein, is thought to regulate neuronal excitability by contributing to the slow component of synaptic after hyperpolarization. However, the role of KCNN1 in tumorigenesis has been rarely reported, and the underlying molecular mechanism remains unclear. Here, we report that KCNN1 functions as an oncogene in promoting breast cancer cell proliferation and metastasis.

"Superaerophobic" NiCo bimetallic phosphides for highly efficient hydrogen evolution reaction electrocatalysts.

A "superaerophobic" NiCo bimetallic phosphide electrocatalyst has been fabricated by employing bimetal-organic frameworks as self-sacrificing templates. An overpotential of only 205 mV can drive the HER current density to 800 mA cm-2, which is even superior to that for Pt/C. This study provides a promising approach for the development of industrialized HER electrocatalysts.