Publications by authors named "Zihou Gao"
Status and analysis of undetected plague cases in Yunnan Province, China.
Front Public Health
September 2024
Article Synopsis
- The study investigated sporadic, undetected cases of plague in Yunnan Province during the COVID-19 pandemic, highlighting the importance of improved surveillance.
- Extensive testing of local wildlife (like rats and domesticated dogs) revealed higher than expected plague infection rates among both animals and local residents.
- The findings suggest that existing surveillance methods may underestimate the actual prevalence of plague infection in humans, emphasizing the need for better monitoring and control measures.
Article Synopsis
- The Seoul orthohantavirus (SEOV) is a major cause of hemorrhagic fever with renal syndrome (HFRS) in China, primarily found in small mammal populations across the country, particularly in Yunnan province.
- A study involving 1,784 small mammals identified 37 SEOV-positive rats, indicating a connection between rodent populations and HFRS outbreaks, while also identifying three SEOV variants, including two novel ones.
- Phylogenetic analysis suggests SEOV originated in the Yunnan-Kweichow Plateau and has since spread globally through rodents, highlighting the need for further research due to the virus's expanding presence and genetic diversity.
Rodents and shrews are major reservoirs of various pathogens that are related to zoonotic infectious diseases. The purpose of this study was to investigate co-infections of zoonotic pathogens in rodents and shrews trapped in four provinces of China. We sampled different rodent and shrew communities within and around human settlements in four provinces of China and characterised several important zoonotic viral, bacterial, and parasitic pathogens by PCR methods and phylogenetic analysis.
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- Bats are hosts to various zoonotic viruses, but little is known about virus diversity and co-infection rates within individual bats, particularly studied in Yunnan, China.* -
- An analysis of 149 bats revealed high levels of virus co-infection and spillover, suggesting that these interactions may enhance virus evolution and emergence.* -
- The study identified five viral species likely pathogenic to humans or livestock, including a novel recombinant SARS-like coronavirus that poses a significant risk due to its ability to bind the human ACE2 receptor.*
Background: Following its resurgence in 1982, rodent plague has been linked to a wide range of circulation risks in Yunnan Province. The most serious public health concern associated with effective plague control is determining how various ecological variables influence the differential risk of transmission.
Methods: We investigated the population dynamics of the hosts and vectors using large-scale epidemiological surveillance data.
Bats are reservoir hosts for many zoonotic viruses. Despite this, relatively little is known about the diversity and abundance of viruses within bats at the level of individual animals, and hence the frequency of virus co-infection and inter-species transmission. Using an unbiased meta-transcriptomics approach we characterised the mammalian associated viruses present in 149 individual bats sampled from Yunnan province, China.
View Article and Find Full Text PDFThis study analyzed the epidemiological characteristics of 3,464 human plague cases and the distribution pattern of 4,968 Yersinia pestis isolates from humans, hosts, and vector insects from 1950 to 2020 among two natural plague foci in Yunnan Province, China. These foci include the Rattus flavipectus plague focus of the Yunnan, Guangdong, and Fujian provinces and the Apodemus chevrieriEothenomys miletus plague focus of the highlands of northwestern Yunnan Province. The case fatality rate for plague in humans was 18.
View Article and Find Full Text PDFHantaviruses are zoonotic pathogens that are widely distributed worldwide. Hantaan virus (HTNV) and Seoul virus (SEOV) are two most common hantaviruses that infect humans and cause hemorrhagic fever with renal syndrome (HFRS). Rapid and sensitive detection of HTNV and SEOV are crucial for surveillance, clinical treatment and management of HFRS.
View Article and Find Full Text PDFInvestigation of Negative Bias Temperature Instability Effect in Nano PDSOI PMOSFET.
Micromachines (Basel)
May 2022
Article Synopsis
- - The study explores the Negative Bias Temperature Instability (NBTI) effect on 130 nm partially depleted silicon-on-insulator (PDSOI) PMOSFETs, focusing on how it impacts their electrical characteristics and performance under stress conditions.
- - Results reveal that NBTI results in a negative shift in threshold voltage, reduced drain current, and decreased transconductance; the work also develops a model predicting that a T-Gate PDSOI PMOSFET has a lifespan of about 18.7 years under specific stress conditions.
- - Additionally, the research finds that T-Gate SOI devices experience greater NBTI degradation compared to floating-body SOI devices, suggesting that the floating-body effect helps mitigate N
Investigation on Ehrlichia Infection in Small Mammals and Ticks from Tengchong, Yunnan Province, Southern China.
Vector Borne Zoonotic Dis
October 2018
Background: Rare investigation on tick-borne pathogens was carried out in Yunnan, China. In this study, we did a survey on Ehrlichia infection in small mammals and ticks. A total of 40 small mammals and 49 ticks were collected from Tengchong, Yunnan province.
View Article and Find Full Text PDFBackground: Babesia, usually found in wild and domestic mammals worldwide, have recently been responsible for emerging malaria-like zoonosis in infected patients. Human B. microti infection has been identified in China, primarily in the Southwest along the Myanmar border but little direct surveillance of B.
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