Congruent and Oriented Crystallization of Mixed Sn-Pb Perovskite From the Nano- to Centimeter Scale.

Metal halide perovskites have garnered widespread attention for research and applications, thanks to their high adaptability in elemental composition and optoelectronic properties. The mixed Sn-Pb perovskite FASnPbI (FA is formamidinium) features a narrow bandgap of 1.25 eV, appropriate for building tandem solar cells, but faces challenges in fabricating uniform, compact films having protected surfaces and scalable dimensions.

VAC: Visual Analysis of Combined Causality in Event Sequences.

Identifying causality behind complex systems plays a significant role in different domains, such as decision-making, policy implementations, and management recommendations. However, existing causality studies on temporal event sequence data mainly focus on individual causal discovery, which is incapable of capturing combined causality. To address the gap in combined causality discovery on temporal event sequence data, eliminating and recruiting principles are defined to balance the effectiveness and controllability of cause combinations.

Establishment of a surfactant-assisted enzymatic modification method for chlorophyll-protein complexes from Auxenochlorella pyrenoidosa to improve chlorophyll stability.

Chlorophylls face significant challenges in practical applications due to their low physicochemical stability. This study investigated the stability of chlorophylls within chlorophyll-protein complexes derived from Auxenochlorella pyrenoidosa and developed a novel surfactant-assisted enzymatic modification strategy to enhance chlorophyll stability. Enzymatic hydrolysis with papain in the presence of Tween 80 increased chlorophyll retention to 88.

The effect and mechanism of atorvastatin regulating PI3K-Akt-mTOR pathway on radiosensitivity of hepatocellular carcinoma cells.

Radiation therapy is an important method to treat liver cancer, but because of the strong DNA repair ability of liver cancer cells, even after receiving high doses of radiation still can not get satisfactory results. Atorvastatin (ATO) is a lipophilic and tissue-selective inhibitor of HMG-CoA reductase whose anticancer effects have been validated in various cells, but its effect on the radiation sensitivity of hepatocellular carcinoma cells remains unclear. Therefore, Therefore, this study explored the radiosensitivity of ATO and its possible mechanism by pretreating HepG2 with ATO and collecting HepG2 cells after irradiation.

Arthrocolin B Impairs Adipogenesis via Delaying Cell Cycle Progression During the Mitotic Clonal Expansion Period.

Obesity and its related diseases severely threaten people's health, causing persistently high morbidity and mortality worldwide. The abnormal proliferation and hypertrophy of adipocytes mediate the expansion of adipose tissue, which is the main cause of obesity-related diseases. Inhibition of cell proliferation during the mitotic clonal expansion (MCE) period of adipogenesis may be a promising strategy for preventing and treating obesity.

Induction Immunochemotherapy Followed by Hypo-Fractionated Radiotherapy in Unresectable Stage III Non-Small Cell Lung Cancer.

Purpose: To evaluate the efficacy and safety of induction immunochemotherapy followed by hypo-fractionated radiotherapy (Hypo-RT) for locally advanced unresectable non-small cell lung cancer (LA-NSCLC).

Methods: This retrospective analysis involved the data of 35 patients with unresectable stage III LA-NSCLC receiving immunotherapy plus Hypo-RT from January 1, 2019, to December 31, 2023. At least 2 cycles of induction immunochemotherapy were initially administered, followed by a definitive Hypo-RT at 4 Gy per fraction.

Stable Luminescent Diradicals: The Emergence and Potential Applications.

Stable luminescent diradicals, characterized by the presence of two unpaired electrons, exhibit unique photophysical properties that are sensitive to external stimuli such as temperature, magnetic fields, and microwaves. This sensitivity allows the manipulation of their spin states and luminescence, setting them apart from traditional closed-shell luminescent molecules and luminescent monoradicals. As a result, luminescent diradicals are emerging as promising candidates for a variety of applications.

Uniting theory and data: the promise and challenge of creating an honest model of facial expression.

People routinely use facial expressions to communicate successfully and to regulate other's behaviour, yet modelling the form and meaning of these facial behaviours has proven surprisingly complex. One reason for this difficulty may lie in an over-reliance on the assumptions inherent in existing theories of facial expression - specifically that (1) there is a putative set of facial expressions that signal an internal state of emotion, (2) patterns of facial movement have been empirically linked to the prototypical emotions in this set, and (3) static, non-social, posed images from convenience samples are adequate to validate the first two assumptions. These assumptions have guided the creation of datasets, which are then used to train unrepresentative computational models of facial expression.

Novel methyldithiocarbazate derivatives as NDM-1 inhibitors to combat multidrug-resistant bacterial infection with β-lactams.

Given the ever-evolving landscape of antimicrobial resistance, the emergence of New Delhi metallo-β-lactamase-1 (NDM-1) has introduced a formidable challenge to global public health. In previous research, we identified the Compound Zndm19 as an NDM-1 inhibitor and reported Zndm19 derivatives, which exhibited moderate antibacterial activity when combined with meropenem (MEM). This moderate activity may have been due to the inability of Zndm19 to efficiently penetrate the bacterial outer membrane or its susceptibility to hydrolysis, which prevented it from exerting strong enzyme inhibition in synergy with bacterial cells.

A Highly Efficient Propeller-Like Organic Radical with Less Solvent Sensitivity and Selective Detection of Aromatic Amines from Aliphatic Amines through Turn-on Fluorescence.

Highly efficient red luminescent organic radicals with less solvent sensitivity are much more attractive due to their wide application in various fields, especially in fluorescence sensing, and bioimaging. In this work, we synthesized a three δ-carboline-capped highly efficient propeller-like organic radical TTM-3δPyID with a D-A structure. The radical showed pure red emission with PLQY of 77.

Establishment of a workflow for high-throughput identification of anti-inflammatory peptides from sea cucumbers.

Developing an effective workflow for screening anti-inflammatory peptides is crucial for discovering novel food-derived anti-inflammatory peptides and optimizing the screening and identification process of bioactive peptides. Virtual screening identified three major yolk proteins as target precursor proteins for anti-inflammatory peptides in sea cucumbers. A portfolio of 170 peptides was identified from hydrolysates after 9 h of alcalase treatment by combining antioxidant activity determination and peptidomics analysis.

In Situ Synthesis of Copper-Based Metal-Organic Frameworks with Ligand Defects for Electrochemical Reduction of CO into C Products.

Electrochemical reduction of CO into high-value-added products is a potential approach to solving environmental problems but is limited by poor product selectivity and low efficiency. Metal-organic framework (MOF) materials have been considered one of the most promising catalysts, but their application is limited by complicated preparation processes, especially during the synthesis of organic ligands. In this work, a new three-dimensional Cu-MOF () with high porosity was constructed based on the naphthalene diimide (NDI) ligand.

Spatio-temporal dynamics of net primary productivity and the economic value of Spartina alterniflora in the coastal regions of China.

This study employs an improved Carnegie-Ames-Stanford Approach (CASA) model to calculate the Net Primary Productivity (NPP) of Spartina alterniflora (SA) and various other land use/land cover types (LULC) across coastal China over multiple years. The research aims to provide significant theoretical and practical insights into carbon sink research in coastal zones, sustainable development, and resource management. Key findings include identifying the first ε value of 2.

Immunocompatible elastomer with increased resistance to the foreign body response.

Polymeric elastomers are extensively employed to fabricate implantable medical devices. However, implantation of the elastomers can induce a strong immune rejection known as the foreign body response (FBR), diminishing their efficacy. Herein, we present a group of immunocompatible elastomers, termed easy-to-synthesize vinyl-based anti-FBR dense elastomers (EVADE).

Novel pleuromutilin derivatives conjugated with phenyl-sulfide and boron-containing moieties as potent antibacterial agents against antibiotic-resistant bacteria.

In response to the escalating threat of microbial resistance, a series of novel pleuromutilin derivatives, conjugated with phenyl-sulfide and boron-containing moieties, were designed and synthesized. Most derivatives, especially 14b and 16b, demonstrated significant efficacy against Gram-positive bacteria, including multidrug-resistant strains, as well as pleuromutilin-resistant strains. Compound 16b showed high stability in the liver microsomes of rats and humans, along with acceptable tolerance in vitro and in vivo.

Acupuncture improve proteinuria in diabetic kidney disease rats by inhibiting ferroptosis and epithelial-mesenchymal transition.

Objective: To explore the mechanism of acupuncture to relieve diabetic proteinuria in Diabetic Kidney Disease (DKD).

Methods: A total of 10 male Sprague-Dawley rats were randomly selected as the negative control group (NC), and a further 30 rats were fed a high-fat diet (HFD) and intraperitoneal streptozotocin (STZ). The DKD model rats in the model group (DKD) and the acupuncture group (DKD + Acu) were randomly assigned.

Dual Channel Emissions of Kasha and Anti-Kasha from a Single Radical Molecule.

Stable open-shell luminescent radicals have recently attracted much attention due to their unique luminescence properties. However, a radical molecule with both Kasha and anti-Kasha doublet emission properties has not been reported. Herein, we have successfully synthesized a stable chlorine-substituted Chichibabin's hydrocarbon, TTM-TTM, along with its mono-radical counterpart, TTM-HTTM.

Modeling and admittance recursive simulation of anti-reflective coatings for photothermal conversion: synergy between subwavelength structures and gradient refractive index layers.

In the field of photothermal conversion, light-absorbing layers show limitations such as low solar energy utilization and excessive surface reflection. This paper proposes a new anti-reflective coating consisting of a gradient-doped fluorescent glass film covering a subwavelength structural layer for photothermal conversion. Its transmittance was simulated using equivalent medium theory and the admittance recursion method.

An elastomer with in situ generated pure zwitterionic surfaces for fibrosis-resistant implants.

Polymeric elastomers are widely utilized in implantable biomedical devices. Nevertheless, the implantation of these elastomers can provoke a robust foreign body response (FBR), leading to the rejection of foreign implants and consequently reducing their effectiveness in vivo. Building effective anti-FBR coatings on those implants remains challenging.

Genome-wide characterization of Remorin gene family and their responsive expression to abiotic stresses and plant hormone in Brassica napus.

Remorin proteins could be positively related to salt and osmotic stress resistance in rapeseed. Remorins (REMs) play a crucial role in adaptations to adverse environments. However, their roles in abiotic stress and phytohormone responses in oil crops are still largely unknown.

Multifunctional Conductive Hydrogel Composites with Nickel Nanowires and Liquid Metal Conductive Highways.

The dramatic growth of smart wearable electronics has generated a demand for conductive hydrogels due to their tunability, stimulus responsiveness, and multimodal sensing capabilities. However, the substantial trade-off between mechanical and electrical properties hinders their multifunctionality. Here, we report a double-network hydrogel composite that features a conductive "highway" constructed using magnetic-field-aligned nickel nanowires and liquid metal.

A Novel Induction-Type Pressure Sensor based on Magneto-Stress Impedance and Magnetoelastic Coupling Effect for Monitoring Hand Rehabilitation.

Visualization of training effectiveness is critical to patients' confidence and eventual rehabilitation. Here, an innovative magnetoinductive pressure sensor is proposed for monitoring hand rehabilitation in stroke hemiplegic patients. It couples the giant magneto and stress-impedance effects of a square spiral amorphous wire with the giant magnetoelastic effect of a polymer magnet (NdFeB@PDMS).

A Guide to Quantify Arabidopsis Seedling Thermomorphogenesis at Single Timepoints and by Interval Monitoring.

Temperature-induced elongation of hypocotyls, petioles, and roots, together with hyponastic leaf responses, constitute key model phenotypes that can be used to assess a plant's capacity for thermomorphogenesis. Phenotypic responses are often quantified at a single time point during seedling development at different temperatures. However, to capture growth dynamics, several time points need to be assessed, and ideally continuous measurements are taken.