Effect of visceral obesity on outcomes of fluorescence-guided lymphadenectomy during laparoscopic gastrectomy for gastric cancer: analysis of a randomized phase 3 trial.

Objective: To explore the impact of visceral fat area (VFA) on the short- and long-term efficacy of indocyanine green (ICG)-guided D2 lymphadenectomy for gastric cancer (GC).

Methods: A analysis was performed in patients who participated in a phase 3 randomized clinical trial of ICG-guided laparoscopic radical gastrectomy conventional laparoscopic radical gastrectomy from November 2018 to July 2019. The VFA was calculated based on preoperative computed tomography images.

Curing and Cross-Linking Processes in the Poly(3,3-bis-azidomethyl oxetane)-tetrahydrofuran/Toluene Diisocyanate/Trimethylolpropane System: A Density Functional Theory and Accelerated ReaxFF Molecular Dynamics Investigation.

The physical and chemical properties of solid propellant are influenced by the composition and structure of the binder, with its network structure being formed through curing and cross-linking reactions. Therefore, understanding the mechanisms of these reactions is crucial. In this study, we investigated the curing and cross-linking mechanisms of poly(3,3-bis-azidomethyl oxetane)-tetrahydrofuran (PBT), toluene diisocyanate (TDI), and trimethylolpropane (TMP) using a combination of density functional theory (DFT) calculations and accelerated ReaxFF molecular dynamics (MD) simulations.

Robotic versus laparoscopic distal gastrectomy for resectable gastric cancer: a randomized phase 2 trial.

Robotic surgery may be an alternative to laparoscopic surgery for gastric cancer (GC). However, randomized controlled trials (RCTs) reporting the differences in survival between these two approaches are currently lacking. From September 2017 to January 2020, 300 patients with cT1-4a and N0/+ were enrolled and randomized to either the robotic (RDG) or laparoscopic distal gastrectomy (LDG) group (NCT03313700).

Laparoscopic Spleen-Preserving Hilar Lymphadenectomy for Advanced Proximal Gastric Cancer Without Greater Curvature Invasion: Five-Year Outcomes From the Fuges-02 Randomized Clinical Trial.

Importance: Splenic hilar lymphadenectomy has been recommended for locally advanced proximal gastric cancer (APGC) involving the greater curvature. However, it is unclear whether laparoscopic spleen-preserving splenic hilar lymphadenectomy (LSPSHL) is associated with a long-term survival benefit for APGC without greater curvature invasion.

Objective: To present the 5-year follow-up data from a randomized clinical trial that compared laparoscopic total gastrectomy (D2 group) with D2 plus LSPSHL (D2 + No.

RPL35 downregulated by mechanical overloading promotes chondrocyte senescence and osteoarthritis development via Hedgehog-Gli1 signaling.

Objectives: To investigate the potential role of Ribosomal protein L35 (RPL35) in regulating chondrocyte catabolic metabolism and to examine whether osteoarthritis (OA) progression can be delayed by overexpressing RPL35 in a mouse compression loading model.

Methods: RNA sequencing analysis was performed on chondrocytes treated with or without 20 % elongation strain loading for 24 h. Experimental OA in mice was induced by destabilization of the medial meniscus and compression loading.

Coherent Sub-Nanometer Interface between Crystalline and Amorphous Materials Boosts Electrochemical Synthesis of Hydrogen Peroxide.

There are enormous yet largely underexplored exotic phenomena and properties emerging from interfaces constructed by diverse types of components that may differ in composition, shape, or crystal structure. It remains poorly understood the unique properties a coherent interface between crystalline and amorphous materials may evoke, and there lacks a general strategy to fabricate such interfaces. It is demonstrated that by topotactic partial oxidation heterostructures composed of coherently registered crystalline and amorphous materials can be constructed.

Down-regulated GAS6 impairs synovial macrophage efferocytosis and promotes obesity-associated osteoarthritis.

Obesity has always been considered a significant risk factor in osteoarthritis (OA) progression, but the underlying mechanism of obesity-related inflammation in OA synovitis remains unclear. The present study found that synovial macrophages infiltrated and polarized in the obesity microenvironment and identified the essential role of M1 macrophages in impaired macrophage efferocytosis using pathology analysis of obesity-associated OA. The present study revealed that obese OA patients and mice showed a more pronounced synovitis and enhanced macrophage infiltration in synovial tissue, accompanied by dominant M1 macrophage polarization.

Effects of manganese on the catalytic performance of CuCo catalysts for direct conversion of CO/CO to higher alcohols.

The catalytic conversion of CO or CO/CO mixtures to higher alcohols (HAs) using hydrogenation reactions remains challenging in C1 chemistry and also one of the most promising reactions for the utilization of non-petroleum resources. Here, the experiment and characterization tests of CuCoMn/AlO show that copper is much more dispersed on γ-AlO than cobalt, and the interaction between cobalt and Mn metals is stronger. And, mixed cobalt-manganese oxides are formed in the calcined catalyst, promoting the formation of higher alcohols.

Formation Mechanism of Monocyclic Aromatic Hydrocarbons during Pyrolysis of Styrene Butadiene Rubber in Waste Passenger Car Tires.

The production of aromatic hydrocarbons from the waste tire pyrolysis attracts more and more attention because of its tremendous potential. Based on styrene-butadiene rubber (SBR), which is the main rubber in the waste passenger car tires, this work studies the temperature influence on primary pyrolysis product distribution by experimental techniques (Py-GC/MS, TG-MS), and then, the formation mechanism of monocyclic aromatic hydrocarbons (MAHs) observed in the experiment was analyzed by first-principles calculations. The experimental results show that the MAHs during the pyrolysis mainly include styrene, toluene, and xylene, and subsequent calculations showed that these compounds were formed through a series of primary and secondary reactions.

Potential dependence of OER/EOP performance on heteroatom-doped carbon materials by grand canonical density functional theory.

Revealing the effect of external applied potential on the reaction mechanism and product selectivity is of great significance in electrochemical studies. In this work, the grand canonical density functional theory method was applied to simulate the explicit electrocatalytic process of oxygen evolution reaction and electrochemical ozone production due to the O product sensitivity toward the applied potential. Over the Pt/Pd single atom embedded on B/N co-doped graphene (Pt/Pd-BNC) surface, crossover points of O/O selectivity inversion were predicted to be 1.

Understanding and tackling the activity and selectivity issues for methane to methanol using single atom alloys.

The process for the direct oxidation of methane to methanol is investigated on single atom alloys using density functional theory. A catalyst search is performed across FCC metal single atom alloys. 7 single atom alloys are found as candidates and microkinetic modelling is performed.

Pentraxin 3 regulated by miR-224-5p modulates macrophage reprogramming and exacerbates osteoarthritis associated synovitis by targeting CD32.

Emerging evidence has shown an imbalance in M1/M2 macrophage polarization to play an essential role in osteoarthritis (OA) progression. However, the underlying mechanistic basis for this polarization is unknown. RNA sequencing of OA M1-polarized macrophages found highly expressed levels of pentraxin 3 (PTX3), suggesting a role for PTX3 in OA occurrence and development.

Oxo dicopper anchored on carbon nitride for selective oxidation of methane.

Selective conversion of methane (CH) into value-added chemicals represents a grand challenge for the efficient utilization of rising hydrocarbon sources. We report here dimeric copper centers supported on graphitic carbon nitride (denoted as Cu@CN) as advanced catalysts for CH partial oxidation. The copper-dimer catalysts demonstrate high selectivity for partial oxidation of methane under both thermo- and photocatalytic reaction conditions, with hydrogen peroxide (HO) and oxygen (O) being used as the oxidizer, respectively.

Mechanical overloading promotes chondrocyte senescence and osteoarthritis development through downregulating FBXW7.

Objectives: To investigate the role of mechanical stress in cartilage ageing and identify the mechanistic association during osteoarthritis (OA) progression.

Methods: F-box and WD repeat domain containing 7 (FBXW7) ubiquitin ligase expression and chondrocyte senescence were examined in vitro, in experimental OA mice and in human OA cartilage. Mice with knockout in chondrocytes were generated and adenovirus-expressing (AAV-Fbxw7) was injected intra-articularly in mice.

Symbolic Transformer Accelerating Machine Learning Screening of Hydrogen and Deuterium Evolution Reaction Catalysts in MAZ Materials.

Two-dimensional (2D) materials have been developed into various catalysts with high performance, but employing them for developing highly stable and active nonprecious hydrogen evolution reaction (HER) catalysts still encounters many challenges. To this end, the machine learning (ML) screening of HER catalysts is accelerated by using genetic programming (GP) of symbolic transformers for various typical 2D MAZ materials. The values of the Gibbs free energy of hydrogen adsorption (Δ) are accurately and rapidly predicted via extreme gradient boosting regression by using only simple GP-processed elemental features, with a low predictive root-mean-square error of 0.

Asporin regulated by miR-26b-5p mediates chondrocyte senescence and exacerbates osteoarthritis progression via TGF-β1/Smad2 pathway.

Objectives: This study aimed to investigate the role and mechanism of asporin in modulating chondrocyte senescence in OA pathology.

Methods: Asporin and senescence-related hallmark expression were examined in human and experimental OA mouse cartilage samples. Twelve-week-old male C57 mice were administered with recombinant protein (rm-asporin)- or asporin-siRNA-expressing lentiviruses via intra-articular injection once a week after destabilization of the medial meniscus (DMM) surgery to induce OA.

High-performance single-atom Ni catalyst loaded graphyne for HO green synthesis in aqueous media.

The electrochemical synthesis of hydrogen peroxide (HO) provides a greener and more efficient method compared with classic catalysts containing toxic metals. Herein, we used first-principles density functional theory (DFT) calculations to investigate 174 different single-atom catalysts with graphyne substrates, and conducted a three-step screening strategy to identify the optimal noble metal-free single atom catalyst. It is found that a single Ni atom loaded on γ-graphyne with carbon vacancies (Ni@V-γ-GY) displayed remarkable thermodynamic stability, excellent selectivity, and high activity with an ultralow overpotential of 0.

Aminooxyacetic acid (AOAA) sensitizes colon cancer cells to oxaliplatin via exaggerating apoptosis induced by ROS.

As the third confirmed gaseous transmitter, the role of hydrogen sulfide (HS) in the pathogenesis of multiple types of cancer has been attracting increasing attention. Increased expression of cystathionine β-synthase (CBS) and HS in colon cancer tissue samples has been validated and tumor-derived HS, mainly produced by CBS, stimulates bioenergetics, cell proliferation, and angiogenesis in colon cancer. Recently, the therapeutic manipulation of HS has been proposed as a promising anticancer approach.

Multiscale Simulation on Product Distribution from Pyrolysis of Styrene-Butadiene Rubber.

Pyrolysis of styrene-butadiene rubber receives renewed attention due to its application in tackling the waste tire disposal problem while allowing energy recovery. The density functional theory calculation (DFT) and ReaxFF molecular dynamics simulation (MD) are adopted to study the pyrolysis process with the variation of temperature and pressure. The bond dissociation energies of intramonomer and intermonomer bonds in trimers with different linking methods are calculated by DFT, where the bond with low energy tends to break during the pyrolysis process.

MoO Nanoparticle Catalysts for d-Glucose Epimerization and Their Electrical Immobilization in a Continuous Flow Reactor.

Activity and immobilization of catalysts in liquid-phase reactions seem not to coexist. We report here the excellent activity of an MoO nanoparticle (NP) catalyst for d-glucose epimerization to d-mannose and the electrical immobilization of NPs in a flow reaction. Prior to that, a green and one-pot method to synthesize the MoO NPs (3.

Prognostic role of secreted protein acidic and rich in cysteine in patients with solid tumors.

To analyze the heterogeneous functions of secreted protein acidic and rich in cysteine (SPARC) from different origins and in different tumor microenvironments with the purpose of determining its clinical significance. Methods: The PubMed, CINAHL, Cochrane, Web of Science and Embase databases were utilized. Studies that focused on the effects of SPARC expression on solid tumor progression and clinical implications were used.

Single and double boron atoms doped nanoporous CN-h2D electrocatalysts for highly efficient N reduction reaction: a density functional theory study.

The electrocatalytical process is the most efficient way to produce ammonia (NH) under ambient conditions, but developing a highly efficient and low-cost metal-free electrocatalysts remains a major scientific challenge. Hence, single atom and double boron (B) atoms doped 2D graphene-like carbon nitride (CN-h2D) electrocatalysts have been designed (B@CN and B@CN), and the efficiency of N reduction reaction (NRR) is examined by density functional theory calculation. The results show that the single and double B atoms can both be strongly embedded in natural nanoporous CN with superior catalytic activity for N activation.