Publications by authors named "Zihao Xin"
Article Synopsis
- A study examined the link between body mass index (BMI) changes in middle adulthood and the risk of fractures in late adulthood, revealing that maintaining a stable BMI may lower fracture risks later in life.
- The research analyzed data from 1,772 participants over 17 years, finding that those who moved from overweight to normal weight faced a significantly higher fracture risk after age 65 compared to those who remained in a normal to slightly overweight BMI range.
- The findings suggest that maintaining a slight increase in weight during midlife could be beneficial for reducing fracture risk in later years, urging overweight individuals to avoid significant weight loss.
Objective: This study aims to identify BMI-associated genes by integrating aggregated summary information from different omics data.
Methods: We conducted a meta-analysis to leverage information from a genome-wide association study (n = 339 224), a transcriptome-wide association study (n = 5619), and an epigenome-wide association study (n = 3743). We prioritized the significant genes with a machine learning-based method, netWAS, which borrows information from adipose tissue-specific interaction networks.