Association between prenatal exposure to phthalate esters and blood pressure in children aged 3-7 years: A prospective cohort study.

Background: An increasing number of animal studies have indicated that exposure to phthalate esters (PAEs) may cause high blood pressure. However, population-based evidence is limited, particularly for pregnant women and young children.

Objective: To examine the correlation between prenatal exposure to phthalate ester metabolites (mPAEs) and blood pressure in preschool children.

Global, regional and national burden of osteoarthritis in 1990-2021: a systematic analysis of the global burden of disease study 2021.

Objectives: To describe the prevalence and incidence of osteoarthritis as well as years lived with disability (YLDs) due to osteoarthritis in 204 countries and territories from 1990 to 2021 by age, sex and socio-demographic index (SDI, a composite of socio-demographic factors).

Methods: Data were acquired from the Global Burden of Diseases, Injuries, and Risk Factors Study 2021 (GBD 2021). The burden of osteoarthritis was estimated for 204 countries and territories from 1990 to 2021by incidence, prevalence and YLDs.

Fish Fin-Derived Non-Invasive Flexible Bioinspired Contact Lens for Continuous Ophthalmic Drug Delivery.

Efficient drug delivery is crucial for glaucoma patients. Flexible biomedical devices that enable sustained ocular drug delivery and can regulate the drug release rate according to physiological conditions are highly desirable for glaucoma treatments, addressing both low drug bioavailability and poor patient compliance from manual drug administration, and improving treatment outcomes. Inspired by the structure and reciprocating motion of fish dorsal fins, a drug-eluting contact lens based on deformable microstructures for non-invasive ocular surface drug delivery is developed.

Epidemiological investigation of adult emergency infusion adverse drug reactions (EIADR) in Nanjing, China: a prospective cross-sectional study (EIADR II).

Objective: To analyze the clinical characteristics of adverse drug reactions (ADRs) in adults receiving emergency infusions at a tertiary hospital.

Methods: We conducted a prospective observational cohort study involving 585 adult patients who experienced adverse drug reactions (ADRs) between 20 November 2019, and 20 November 2023, during intravenous infusions in the emergency infusion room of a tertiary hospital. The analysis included patients' gender, age, type of drugs involved, organ-system involvement, clinical manifestations of ADRs, severity grading of ADRs, and preventability of ADRs.

Circular RNA CDR1as/ciRS-7- a novel biomarker in solid tumors.

Introduction: Circular RNA CDR1as/ciRS-7 has been reported to function as an oncogenic regulator in various cancers. However, the prognostic value of CDR1as/ciRS-7 expression in solid tumors remains unclear. Herein, we conducted an updated meta-analysis to investigate the association between CDR1as/ciRS-7 expression and clinical outcomes in solid tumors.

MaxEnt and Marxan modeling to predict the potential habitat and priority planting areas of in Yunnan, China under climate change scenario.

Introduction: (Arabica coffee) is an important cash crop in Yunnan, China. Ongoing climate change has made coffee production more difficult to sustain, posing challenges for the region's coffee industry. Predictions of the distribution of potentially suitable habitats for Arabica coffee in Yunnan could provide a theoretical basis for the cultivation and rational management of this species.

Design of information management model based on multiobjective optimization algorithm in intelligent electric financial system.

The electric power infrastructure is the cornerstone of contemporary society's sustenance and advancement. Within the intelligent electric power financial system, substantial inefficiency and waste in information management persist, leading to an escalating depletion of resources. Addressing diverse objectives encompassing economic, environmental, and societal concerns within the power system helps the study to undertake a comprehensive, integrated optimal design and operational scheduling based on a multiobjective optimization algorithm.

Corrigendum: Evaluating the role of pericoronary adipose tissue on coronary artery disease: insights from CCTA on risk assessment, vascular stenosis, and plaque characteristics.

[This corrects the article DOI: 10.3389/fcvm.2024.

Chidamide combined with azacitidine as a novel double epigenetic preemptive treatment for a myelodysplastic syndrome patient showing molecular relapse after allogeneic hematopoietic stem cell transplantation.

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is theoretically the only curative option for high-risk myelodysplastic syndrome (HR MDS) patients. However, the management of patients with relapsed disease post allo-HSCT remains a challenge with few standard treatments. Chidamide, a new selective histone deacetylase, has shown synergistic anti-leukemia effect combined with azacitidine in acute myeloid leukemia patients.

FAM3C Regulates Glioma Cell Proliferation, Invasion, Apoptosis, and Epithelial Mesenchymal Transition via the Notch Pathway.

Background: Previous studies have implicated the involvement of FAM3C in cancerous development and progression. Herein, we aimed to further investigate the oncological mechanism of FAM3C, specifically in glioma.

Methods: We utilized open-source bioinformatics tools and platforms to analyze the transcriptional expression levels, prognosis, and correlation with clinical variables of FAM3C in gliomas, and subsequently, to hypothesize its potential molecular functions and possibly associated signaling pathways.

Ni Ion-Induced Phase and Morphology Tailoring in Ni-CuMoSe Nanorod Catalysts for Overall Water Splitting.

Copper molybdenum-based selenides (CuMoSe) as promising hydrogen evolution catalysts have been widely applied in the electrocatalytic splitting of water, while their limited active sites and relatively poor oxygen evolution activity restrict their further application as effective bifunctional electrocatalysts. Here, we report a simple hydrothermal method to fabricate rodlike NiCuMoSe arrays on nickel foam (Ni-CuMoSe/NF), the morphology of which is determined by Ni ions because Ni can promote the growth of the rodlike structure. Furthermore, the phase transformation from CuSe to CuSe is triggered by adjusting the Ni ion content of the growth solution.

A Metal-Polyphenol-Based Antidepressant for Alleviating Colitis-Associated Mental Disorders.

Emerging evidence suggests that patients with inflammatory bowel diseases (IBDs) are predisposed to psychosocial disturbances, such as depression and anxiety. Regrettably, clinical antidepressants exhibit unsatisfactory therapeutic efficacy in IBD-associated psychosocial disturbances, primarily attributed to the inherent intestinal disorders and intricate bidirectional relationship between the gut and the brain. Herein, we report a metal-polyphenol-based antidepressant to alleviate mental disorders in dextran sulfate sodium-induced experimental acute colitis mice via modulating the microbiota-gut-brain axis.

Ferroptosis and its implications in bone-related diseases.

Ferroptosis, a recently recognized form of regulated cell death (RCD) characterized by iron-dependent lipid peroxide accumulation, has emerged as a noteworthy regulator in various bone-related diseases, including osteoporosis (OP), osteoarthritis (OA), and osteosarcoma (OS). OS primarily afflicts the elderly, rendering them susceptible to fractures due to increased bone fragility. OA represents the most prevalent arthritis in the world, often observed in the aging population.

α-Ketoglutaric Acid Reprograms Macrophages by Altering Energy Metabolism to Promote the Regeneration of Small-Diameter Vascular Grafts.

Small-diameter vascular grafts still cannot clinically replace autologous blood vessels due to high restenosis rates caused by long-term inflammatory infiltration. Foreign body reactions to vascular grafts induce macrophages to adopt the pro-inflammatory M1 phenotype, releasing inflammatory factors such as interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α). This induces a phenotypic switch in smooth muscle cells, eventually leading to intimal hyperplasia.

Targeted Synthesis of Interpenetration-Free Mesoporous Aromatic Frameworks by Manipulating Catalysts as Templates.

Reticular chemistry allows the design and synthesis of mesoporous networks by extending the size of the building blocks. However, interpenetration of the nets easily happens against the designed mesoporous networks, thereby falling short of achieving the intended specific surface area and pore size. Controlling the framework interpenetration has always been a challenge in the synthesis section of reticular chemistry.

Characterization of Coulomb Interactions in Electron Transport Through a Single Hetero-Helicene Molecular Junction Using Scanning Tunneling Microscopy.

Characterization of the structural and electron transport properties of single chiral molecules provides critical insights into the interplay between their electronic structure and electrochemical environments, providing broader implications given the significance of molecular chirality in chiroptical applications and pharmaceutical sciences. Here, we examined the topographic and electronic features of a recently developed chiral molecule, B,N-embedded double hetero[7]helicene, at the edge of Cu(100)-supported NaCl thin film with scanning tunneling microscopy and spectroscopy. An electron transport energy gap of 3.

A compact, palm-sized isothermal fluorescent diagnostic intelligent IoT device for personal health monitoring and beyond via one-tube/one-step LAMP-CRISPR assay.

The demand for accurate, user-friendly, and sensitive at-home nucleic acid testing solutions is rising due to occasional outbreaks of various infectious diseases and a growing desire for an improved quality of life. In response, we developed the WeD-mini, a compact, palm-sized isothermal fluorescent diagnostic IoT device that weighs just 61 g. The WeD-mini features a uniquely designed, highly sensitive optical sensing system, ultra-low power consumption, a minimalist industrial design, and an intelligent operating algorithm.