Photocatalytic activation of peroxymonocarbonate with a TiO catalyst for water remediation.

The novel advanced oxidation process was constructed to remove pollutants by activating in-situ generated peroxymonocarbonate (HCO) through photocatalysis, using commercially available rutile TiO as the photocatalyst. It demonstrated exceptional oxidative capacity, achieving complete degradation of acid red (AR73) within 30 min, and efficiently oxidizing various recalcitrant organic pollutants. Further, the photocatalytic system had a good resistance to interference and was smoothly conducted in a variety of water matrix with a wide range of pH (3-9).

Rhizosphere microbiome metagenomics in PGPR-mediated alleviation of combined stress from polypropylene microplastics and Cd in hybrid Pennisetum.

The simultaneous presence of microplastics (MPs) and heavy metals in soil may result in heightened toxicity, causing more significant adverse effects on plant growth. Plant growth-promoting rhizobacteria (PGPR) have demonstrated significant capacities in alleviating the toxic stress caused by the combined pollution of heavy metals and other contaminants. However, research on the impacts and processes of PGPR in alleviating stress induced by the combined pollution from MPs and heavy metals is still insufficient.

Dental pulp stem cells alleviate Schwann cell pyroptosis via mitochondrial transfer to enhance facial nerve regeneration.

Dental pulp stem cells (DPSCs) have demonstrated remarkable potential in enhancing peripheral nerve regeneration, though the precise mechanisms remain largely unknown. This study investigates how DPSCs alleviate Schwann cell pyroptosis and restore mitochondrial homeostasis through intercellular mitochondrial transfer. In a crab-eating macaque model, we first observed that DPSC-loaded nerve conduits significantly promoted long-term nerve regeneration, facilitating tissue proliferation and myelin recovery.

Study on the Evolution of Deformation Trend in Laser Powder Bed Fusion Samples Based on a Novel Monitoring System.

During the LPBF (Laser Powder Bed Fusion) process, excessive residual stress can lead to a decline in the forming quality of printed parts. Residual stress is the primary cause of part deformation; therefore, monitoring the part deformation trend can, to a certain extent, reflect the overall residual stress level of the part. Online stress or deformation monitoring presents significant challenges due to the part being covered by powder and the need for a sealed environment.

Targeting TUBB2B inhibits triple-negative breast cancer growth and brain-metastatic colonization.

Background: The triple-negative subtype of breast cancer is particularly challenging to treat due to its aggressiveness with a high risk of brain metastasis, and the lack of effective targeted therapies. Tubulin beta 2B class IIb (TUBB2B), a β-tubulin isoform regulating axon guidance during embryonic development, was found to be overexpressed in various types of cancers including triple-negative breast cancer (TNBC). However, its functional roles in breast cancer or metastasis remain unclear.

Role of sulfatase LPMS from Lactiplantibacillus plantarum dy-1 in releasing bound phenolic acids of barley bran dietary fiber.

Latic acid fermentation is an effective way to release the bound phenolic acids from grains dietary fiber to improve the biological effects in vivo. Previous analysis of whole genome sequencing and comparative proteomics has revealed that a sulfatase named LPMS in Lactiplantibacillus plantarum dy-1 (L. plantarum dy-1) was the potential key enzyme in promoting the release of bound phenol from barley bran dietary fiber.

Cold-related genes BcCOR15B and BcCOR15A have environment adapted expression pattern in non-heading Chinese cabbage.

In this work, two cold-related (COR) genes, BcCOR15B and BcCOR15A, were isolated from non-heading Chinese cabbage (Brassica rapa ssp. chinensis cv. Suzhouqing).

Effect of age, harvest site and body mass index on the cell composition of the stromal vascular fraction.

Background: The stromal vascular fraction (SVF) of adipose tissue has now been widely used in plastic surgeries, clinical trials and therapies. However, the cell composition of SVF undergoes dynamic changes during aging and obesity, which may influence the efficacy of the SVF. This study analyzed the effects of age, harvest site and body mass index on the cell composition of the SVF.

Bidirectional relationships between phonological processing and basic number knowledge in kindergarten children: a longitudinal study.

An ongoing debate on the association between phonological processing and number knowledge concerns the extent to which they influence each other during early childhood. The current study aims to establish the direction of the developmental relationship between these two kinds of abilities at an early age. Eighty-two Chinese kindergarten children were followed from 5 to 6 years old with a one-year interval.

Circulating Tumor Cells Culture: Methods, Challenges, and Clinical Applications.

Circulating tumor cells (CTCs) play a pivotal role in cancer metastasis and hold considerable potential for clinical diagnosis, therapeutic monitoring, and prognostic evaluation. Nevertheless, the limited quantity of CTCs in liquid biopsy samples poses challenges for comprehensive downstream analysis. In vitro culture of CTCs can effectively address the issue of insufficient CTC numbers.

Pathological mechanisms of glial cell activation and neurodegenerative and neuropsychiatric disorders caused by infection.

is an intracellular opportunistic parasite that exists in a latent form within the human central nervous system (CNS), even in immune-competent hosts. During acute infection, traverses the blood-brain barrier (BBB). In the subsequent chronic infection phase, the infiltration of immune cells into the brain, driven by infection and the formation of parasitic cysts, leads to persistent activation and proliferation of astrocytes and microglia.

Assessing male reproductive toxicity of environmental pollutant di-ethylhexyl phthalate with network toxicology and molecular docking strategy.

Environmental pollutants, especially endocrine-disrupting chemicals (EDCs) like di-ethylhexyl phthalate (DEHP), pose serious threats to human health, with DEHP widely implicated in male reproductive toxicity. However, the complex molecular interactions remain unknown. We employed a network toxicology approach combined with molecular docking analysis to identify potential targets and mechanisms of DEHP's toxic effects.

Reconsideration of the role of hydrogen peroxide in peroxymonocarbonate-based oxidation system for pollutant control.

Advanced oxidation processes that utilize peroxymonocarbonate (HCO), generated in-situ through the reaction of HCO and HO, are employed for the removal of pollutants in water. Nevertheless, the precise role of HO in these processes remains a subject of debate. This study established a HCO-based oxidation system using NaHCO and HO for the degradation of acetaminophen and investigated the activation mechanisms of coexisting oxidants.

GelMA-based moldable and rapid-curable osteogenic paste inspired by ceramic craft for alveolar bone defect regeneration.

Alveolar bone defects pose a significant challenge in oral clinical treatments, impacting procedures such as dental implants, orthodontics, and oral restoration. Despite their frequent occurrence due to various causes, the effective restoration and reconstruction of alveolar bone defects remain a significant clinical challenge in dentistry. Existing treatments often rely on intrinsic blood coagulation to stabilize bone grafts, but they present limitations such as gradual clotting and reduced effectiveness in patients with coagulation dysfunction.

Influences of dy-1 Fermentation on the Bitterness of Bitter Melon Juice, the Composition of Saponin Compounds, and Their Bioactivities.

Lactic acid bacteria fermentation is a beneficial bioprocessing method that can improve the flavor, transform nutrients, and maintain the biological activity of foods. The aim of this study is to investigate the effects of dy-1 fermentation on the nutritional components, flavor and taste properties, and composition of saponin compounds and their hypolipidemic and antioxidant activities. The results suggested that the total polyphenol content increased, and the soluble polysaccharides and total saponin contents decreased in fermented bitter melon juice (FJ) compared with those in non-fermented bitter melon juice (NFJ).

Generation of a zebrafish neurofibromatosis model via inducible knockout of nf2a/b.

Neurofibromatosis type 2 (NF-2) is a dominantly inherited genetic disorder that results from variants in the tumor suppressor gene, neurofibromin 2 (NF2). Here, we report the generation of a conditional zebrafish model of neurofibromatosis established by inducible genetic knockout of nf2a/b, the zebrafish homologs of human NF2. Analysis of nf2a and nf2b expression revealed ubiquitous expression of nf2b in the early embryo, with overlapping expression in the neural crest and its derivatives and in the cranial mesenchyme.

NAT10/ac4C/JunB facilitates TNBC malignant progression and immunosuppression by driving glycolysis addiction.

Background: N4-Acetylcytidine (ac4C), a highly conserved post-transcriptional mechanism, plays a pivotal role in RNA modification and tumor progression. However, the molecular mechanism by which ac4C modification mediates tumor immunosuppression remains elusive in triple-negative breast cancer (TNBC).

Methods: NAT10 expression was analyzed in TNBC samples in the level of mRNA and protein, and compared with the corresponding normal tissues.

Environmental simulation and refrigeration demand analysis for shield tunnel construction in hot summer and cold winter regions.

The thermal hazards generated during the tunnel boring machine construction process significantly impact the physical and mental health of personnel. A field test was conducted on the tunnel of Metro Line 1 in Changsha, China, where the average temperature in the work zone reached up to 33.16 °C, and the air velocity was generally below 0.

Bimetallic Sulfur-Doped Nickel-Cobalt Selenides as Efficient Bifunctional Electrocatalysts for the Complete Decomposition of Water.

The creation and enhancement of non-precious metal bifunctional catalysts with superior stability and stabilizing activity is necessary to achieve water splitting in alkaline media. The paper presents a method for preparing nickel-cobalt bimetallic selenides (NiCo-Se/CF) using a combination of hydrothermal and high-temperature selenization techniques. NiCo-Se/CF shows great potential as a catalyst for water separation.

Integrin-linked kinase control dental pulp stem cell senescence via the mTOR signaling pathway.

Human dental pulp stem cells (HDPSCs) showed an age-dependent decline in proliferation and differentiation capacity. Decline in proliferation and differentiation capacity affects the dental stromal tissue homeostasis and impairs the regenerative capability of HDPSCs. However, which age-correlated proteins regulate the senescence of HDPSCs remain unknown.

Optical coherence tomography otoscope for imaging of tympanic membrane and middle ear pathology.

Significance: Pathologies within the tympanic membrane (TM) and middle ear (ME) can lead to hearing loss. Imaging tools available in the hearing clinic for diagnosis and management are limited to visual inspection using the classic otoscope. The otoscopic view is limited to the surface of the TM, especially in diseased ears where the TM is opaque.

Cereal-Derived Water-Unextractable Arabinoxylans: Structure Feature, Effects on Baking Products and Human Health.

Arabinoxylans (AXs) are non-starch polysaccharides with complex structures naturally occurring in grains (i.e., barley, corn, and others), providing many health benefits, especially as prebiotics.