Multiple time points of transcriptome analysis revealed altered genes involved in maintaining hibernation in the hypothalamus of .

Hibernation, an adaptive mechanism to extreme environmental conditions, is prevalent among mammals. Its main characteristics include reduced body temperature and metabolic rate. However, the mechanisms by which hibernating animals re-enter deep sleep during the euthermic phase to sustain hibernation remain poorly understood.

Research on Pine Wilt Disease Spread Prediction Based on an Improved LGBM Model.

Pine wilt disease has caused significant damage to China's ecological and financial resources. To prevent its further spread across the country, proactive control measures are necessary. Given the low accuracy of traditional models, we have employed an enhanced LightGBM model to predict the development trend of pine wilt disease in China.

Enzyme fragment complementation driven by nucleic acid hybridization sans self-labeling protein.

A modified enzyme fragment complementation assay has been designed and validated as a turn-on biosensor for nucleic acid detection in dilute aqueous solution. The assay is target sequence-agonistic and uses fragments of NanoBiT, the split luciferase reporter enzyme, that are esterified enzymatically at their C-termini to steramers, sterol-linked oligonucleotides. The Drosophila hedgehog autoprocessing domain, DHhC, serves as the self-cleaving enzyme for the NanoBiT-steramer bioconjugations.

S100A11 promotes lipid metabolism and activates the apoptosis in polycystic ovary syndrome.

Apoptosis of ovarian granulosa cells (GCs) affects the development and maturation of oocyte in Polycystic ovary syndrome (PCOS).The objective of our study was to examine the impact of S100A11 on granulosa cells in individuals with polycystic ovary syndrome. We found that the S100A11 level was higher in the ovarian granulosa cells of PCOS patients and ovarian tissue of PCOS mouse models.

Origin of fast charging in solid-state batteries revealed by Cryo-transmission X-ray microscopy.

The interface issue poses a limitation on the fast charging of solid-state batteries (SSBs), with the high-impedance non-Faraday electric field serving as a pivotal factor. However, the mechanism of fast-charging capability degradation triggered by the dynamic evolution of non-Faraday electric fields remains unclear due to the lack of particle-scale nondestructive detection techniques. Here, we dissect the generation and elimination processes of non-Faradaic electric field in segments using the developed operando cryogenic transmission X-ray microscopy (Cryo-TXM).

Deciphering genomic codes using advanced NLP techniques: a scoping review.

Objectives: The vast and complex nature of human genomic sequencing data presents challenges for effective analysis. This review aims to investigate the application of Natural Language Processing (NLP) techniques, particularly Large Language Models (LLMs) and transformer architectures, in deciphering genomic codes, focusing on tokenization, transformer models, and regulatory annotation prediction. This review aims to assess data and model accessibility in the most recent literature, gaining a better understanding of the existing capabilities and constraints of these tools in processing genomic sequencing data.

Key Role of Cross-Linking Homogeneity in Polyurethane Mechanical Properties: Insights from Molecular Dynamics.

Polyurethane (PU) grouting materials play a crucial role in trenchless rehabilitation with their mechanical properties significantly influenced by the cross-linking degree and cross-linking uniformity. This study investigates the effects of inhomogeneous cross-linking on the mechanical behavior of PU, an area that remains underexplored. We developed PU molecular models with varying cross-linking degrees and cross-linking uniformity, quantitatively described by the parameter .

Prognostic risk prediction model for patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD): a systematic review and meta-analysis.

Background: Chronic obstructive pulmonary disease (COPD) is a prevalent respiratory condition and a leading cause of mortality, with acute exacerbations (AECOPD) significantly complicating its management and prognosis. Despite the development of various prognostic prediction models for patients with AECOPD, their performance and clinical applicability remain unclear, necessitating a systematic review to evaluate these models and provide guidance for their future improvement and clinical use.

Method: PubMed, Web of Science, CINAHL, Scopus, EMBASE, and Medline were searched for studies published from their inception until February 5, 2024.

The active ingredient β-sitosterol in Ganoderma regulates CHRM2-mediated aerobic glycolysis to induce apoptosis of lung adenocarcinoma.

Background: β-sitosterol is a natural plant steroidal compound with anti-cancer properties against various tumors. This work attempts to explore the inhibitory effect of β-sitosterol on the progression of lung adenocarcinoma (LUAD) and further analyze its targets.

Methods: In this work, we applied network pharmacology to obtain the components and targets of Ganoderma spore powder.

Disrupting Intracellular Homeostasis by Copper-Based Nanoinducer with Multiple Enzyme-Mimicking Activities to Induce Disulfidptosis-Enhanced Pyroptosis for Tumor Immunotherapy.

Given the crucial role of abnormal homeostasis in tumor cells for maintaining their growth, it may be more efficient with less effort to develop anti-tumor strategies that target multiple combined mechanisms by disrupting intracellular homeostasis. Here, a copper-based nanoinducer (CGBH NNs) with multiple enzyme-like activities is designed and constructed to induce disulfidptosis-enhanced pyroptosis through disrupting multiple intracellular homeostasis for effective tumor immunotherapy. Within the tumor microenvironment (TME), CGBH NNs can disrupt intracellular glucose homeostasis and inhibit NADPH production, leading to accumulation of cystine, which further blocked the substrate and key enzyme for synthesizing glutathione.

Joint Modifiable Risk Factor Control and Incident Stroke in Hypertensive Patients.

Recent guidelines have recognized several factors, including blood pressure (BP), body mass index (BMI), low-density lipoprotein cholesterol (LDL-C), hemoglobin A1c (HbA1c), smoking, and physical activity, as key contributors to stroke risk. However, the impact of simultaneous management of these risk factors on stroke susceptibility in individuals with hypertension remains ambiguous. This study involved 238 388 participants from the UK Biobank, followed up from their recruitment date until April 1, 2023.

Nanotechnology based gas delivery system: a "green" strategy for cancer diagnosis and treatment.

Gas therapy, a burgeoning clinical treatment modality, has garnered widespread attention to treat a variety of pathologies in recent years. The advent of nanoscale gas drug therapy represents a novel therapeutic strategy, particularly demonstrating immense potential in the realm of oncology. This comprehensive review navigates the landscape of gases endowed with anti-cancer properties, including hydrogen (H), carbon monoxide (CO), carbon dioxide (CO), nitric oxide (NO), oxygen (O), sulfur dioxide (SO), hydrogen sulfide (HS), ozone (O), and heavier gases.

Photo-assisted conversion of tetracycline in regulated persulfate system: Multiple roles of natural dissolved organic matter.

Advanced oxidation processes (AOPs) using persulfate system can effectively remove organic pollutants. However, dissolved organic matter (DOM) has multiple effects on AOPs efficiency, and the influence of DOMs from natural sources on AOPs is still unclear. In this study, we explored the effects of soil DOM (SDOM) and fertilizer DOM (FDOM) on tetracycline (TC) removal by persulfate systems.

A novel fluorescent probe based on dicyanoisophorone derivatives for hypochlorite detection in living cells.

This study presents a long-wavelength fluorescent probe CNC for the detection of ClO in vitro and in vivo. Upon interaction with ClO, this probe exhibited a significant increase in fluorescence, with a significant Stokes shift (169 nm), lower detection limit (1.38 μM), high sensitivity and selectivity.

Rapamycin and Hyperoside-Co-loaded Macrophage Delivery System Enhanced Pulmonary Fibrosis Therapy by Autophagy Upregulation and Epithelial-to-Mesenchymal Transition Inhibition.

Pulmonary fibrosis is a lethal interstitial lung disease, for which current treatments are inadequate in halting its progression. A significant factor contributing to the development of fibrosis is insufficient autophagy, which leads to increased fibroblast proliferation and collagen deposition. However, treatments aimed at upregulating autophagy often cause further lung pathology due to the disruption of epithelial cell balance.

Transcriptome analysis reveals high concentration of resveratrol promotes lipid synthesis and induces apoptosis in Siberian sturgeon (Acipenser baerii).

Resveratrol has been reported to promote immunity and decrease oxidative stress, but which demonstrates biphasic effects relied on the use concentration. In this study, the effects of diet supplement with a relative high concentration of resveratrol (0.32 mg/kg) on metabolism, antioxidation and apoptosis of liver were investigated in Siberian sturgeon.

Multimodal integrated and broadband light-driven antibacterial cellulose fabric based on π-π coupling enhanced intermolecular FRET.

Fabrication of antimicrobial photodynamic therapy (aPDT) materials based on organic photosensitizers has garnered considerable attention within functional textiles. However, the UV- or narrow-band absorption range of the photosensitizers results in poor photon utilization of the fabrics, limiting the photodynamic efficiency and wasting solar energy. In this study, a broadband light-driven antibacterial cellulose fabric (CF-ZnPc/NAD) was developed by loading carboxyl-modified zinc(II) phthalocyanine photosensitizer (CAZnPc) and cationic 1,8-naphthalimide fluorescent molecule (NAD) on the fabric via covalent binding and electrostatic adsorption assembly, facilitating the intermolecular π-π coupling and fluorescence resonance energy transfer (FRET) process.