Publications by authors named "Zihan Jiang"

Article Synopsis
  • - The study investigates how changes in peripheral adaptive immune cells affect metabolic profiles in a ketamine-treated mouse model of schizophrenia, suggesting a link between immune responses and mental health issues.
  • - Using flow cytometry and advanced metabolomics techniques, researchers found an increase in CD3 T cells and notable alterations in amino acid metabolism, particularly elevated levels of glycine, alanine, asparagine, and aspartic acid.
  • - Although the research highlights the role of peripheral amino acid metabolism in ketamine-induced schizophrenia symptoms, it has yet to pinpoint the specific metabolic pathways responsible for these changes.
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  • Intracerebral calcium deposition includes primary familial brain calcification (PFBC), which leads to motor decline, speech difficulties, and cognitive issues, with limited treatment options available.* -
  • Recent findings link PFBC to blood-brain barrier dysfunction, influenced by genetic variants that affect the neurovascular unit (NVU), leading to brain calcification.* -
  • The review examines literature on genetic mutations in cell junction proteins related to brain calcification, aiming to identify molecular pathways and support the need for molecular subtyping in understanding this condition.*
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Background: Parkinson's disease (PD) has been linked to T helper 17 (Th17) cells in prior investigations, but the evidence remains inconclusive. To gain a deeper understanding of this potential connection, we conducted a systematic review and meta-analysis.

Methods: A comprehensive search for relevant studies published up to July 8, 2023, was performed across PubMed, EMBASE, and Cochrane Library databases.

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  • The study examined how the dysfunction of the nigrostriatal dopamine system affects sleep disturbances in newly diagnosed Parkinson's disease patients, focusing on excessive daytime sleepiness and probable RBD.
  • Data was collected from 621 patients over four years through established sleep scales and dopamine transporter imaging.
  • Results showed a negative correlation between dopamine transporter binding ratios and sleep issues, suggesting that dopamine dysfunction and genetic factors (like the alpha-synuclein gene) significantly contribute to sleep disturbances in these patients.
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  • * Research highlights the connection between the immune system and the nervous system, particularly the role of immune cells entering the brain in certain psychiatric disorders.
  • * The article aims to fill gaps in existing literature by exploring how peripheral immune changes contribute to ketamine-related psychiatric symptoms, highlighting their importance in understanding mental health issues and potential treatment approaches.
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  • - The study investigates the voltage-to-mass ratio as a diagnostic tool for cardiac amyloidosis (CA) by comparing it across different patient groups and healthy controls.
  • - Researchers analyzed data from 213 CA patients and other heart-related groups, finding that CA patients had lower voltage-to-mass ratios, which were significantly associated with their condition.
  • - The optimal cut-off value for diagnosing CA, using the cross-sectional area method, was established at 16.42 mV/mm/m, showing high sensitivity and specificity and highlighting the potential for this method to replace more invasive diagnostics.
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Objective: This study aimed to evaluate the efficacy of autologous blood preparations, namely Platelet-Rich Plasma (PRP), Platelet-Rich Fibrin (PRF), and Concentrated Growth Factor (CGF), in maxillary sinus floor elevation surgery. The focus was on their impact on new bone formation, maxillary sinus floor height, and soft tissue healing.

Methods: A systematic search was conducted across PubMed/MEDLINE, Web of Science, Embase, and Scopus databases up to April 2024.

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Glufosinate is a widely and increasingly used non-selective, broad-spectrum herbicide. Although cases of glufosinate poisoning are frequently reported, they are rarely documented in forensic case reports, particularly in fatal instances. The present study examined six cases of glufosinate poisoning, including a fatal case involving a 25-year-old female found deceased by the roadside, with an empty 1000 mL bottle labeled "glufosinate" by her side.

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Objective: To evaluate the accuracy of expanded noninvasive prenatal testing (NIPT) for maternal copy number variations.

Materials And Methods: Expanded NIPT was used to detect CNVs ≥2 Mb at a whole-genome scale. The threshold of maternal deletion was copy numbers (CN) ≤ 1.

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Epidemiological evidence indicates an association between exposure to toxic metals and the occurrence of cardiometabolic diseases (CMDs). However, the impact of exposure to harmful metallic elements, such as lead (Pb), cadmium (Cd), and mercury (Hg), on mortality in individuals with cardiometabolic multimorbidity (CMM) remains uncertain. Therefore, in this study, we analyzed data from 4139 adults diagnosed with CMM from the National Health and Nutrition Examination Survey 1999-2016.

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Background: As exacerbations of chronic obstructive pulmonary disease (COPD) are one of the leading causes of hospitalization and are associated with significant mortality, it is particularly important to accurately assess the risk of exacerbations in COPD. Most of the current clinical biomarkers are related to inflammation and few consider how ion levels affect COPD. Chloride ion, the second most abundant serum electrolyte, has been shown to be associated with poor prognoses in several diseases, but their relationship with COPD remains unclear.

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The unclear pathogenic mechanisms of neurodegenerative disorders stemming from NOTCH2NLC GGC repeat expansions drive focused research. Thus, a bibliometric and meta-analysis was conducted to uncover research trends and positivity rates in NOTCH2NLC. We conducted systematic searches in the Web of Science, PubMed, Embase, and Scopus databases for studies related to NOTCH2NLC up until August 2, 2023.

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Background: Insufficient clinicians' auscultation ability delays the diagnosis and treatment of valvular heart disease (VHD); artificial intelligence provides a solution to compensate for the insufficiency in auscultation ability by distinguishing between heart murmurs and normal heart sounds. However, whether artificial intelligence can automatically diagnose VHD remains unknown. Our objective was to use deep learning to process and compare raw heart sound data to identify patients with VHD requiring intervention.

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Epidemiological evidence suggests associations between exposure to polycyclic aromatic hydrocarbons (PAHs) and cardiovascular diseases (CVD), while diabetes is a common risk factor for CVD. The present study aims to clarify the effect of high PAH exposure on diabetes and stroke in general population. A total of 7849 individuals aged 20 years or older from the National Health and Nutrition Examination Survey 2007-2016 were included in the study.

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Cancer is a major global health issue. Effective therapeutic strategies can prolong patients' survival and reduce the costs of treatment. Drug repurposing, which identifies new therapeutic uses for approved drugs, is a promising approach with the advantages of reducing research costs, shortening development time, and increasing efficiency and safety.

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The application of both chemotherapy and ferrotherapy together has shown great potential in increasing the effectiveness of cancer treatment. To achieve such a combination, we herein have synthesized FeOcore/MIL-100(Fe) shell nanocomposites (FM) that can be used for tumor chemo-ferroptosis combination therapy. In these nanocomposites, the anticancer drug 10-hydroxycamptothecin (HCPT) and iron ions could be co-delivered into tumors.

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Background: In recent years, the role of ferroptosis in Parkinson's disease (PD) has become a research hotspot based on evidence of abnormal iron deposition and lipid peroxidation damage in the brains of PD patients. This study aims to examine the relevant research on ferroptosis and PD from a bibliometric perspective.

Methods: Original research and review articles related to ferroptosis and PD were retrieved from the Web of Science Core Collection (WOSCC) database.

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Article Synopsis
  • The study investigated whether SGLT2 inhibitors can reduce the occurrence of atrial fibrillation (AF) in patients with cardiometabolic diseases, finding inconclusive results.
  • A comprehensive review of 46 randomized, placebo-controlled trials involving over 101,000 patients showed no significant risk reduction for AF with SGLT2 inhibitors, despite a slight favorable trend.
  • The results were consistent across different types and doses of SGLT2 inhibitors and across varied patient groups, concluding that these medications do not lower AF occurrence risk among those with cardiometabolic issues.
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Background: The vein of Marshall (VOM) ethanol infusion improves rhythm control in atrial fibrillation (AF). The identification and cannulation of the VOM can be technically challenging. This study aimed to assess the angiographic morphology of the VOM and investigate its value in the VOM ethanol infusion.

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  • This study investigates the link between Parkinson's disease (PD) and periodontitis, given mixed results from previous observational studies.
  • A thorough review and meta-analysis of 34 studies found no significant association between periodontitis and increased risk of PD, nor vice versa.
  • However, individuals with PD showed worse oral health indicators, suggesting higher prevalence of periodontitis and poor oral conditions in these patients compared to healthy individuals.
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Background: The vein of Marshall (VOM) ethanol infusion is increasingly performed in combination with catheter ablation in atrial fibrillation (AF). The cannulation of the VOM can sometimes be challenging. This study aimed to evaluate the double-wire technique in cases of difficult cannulation of the VOM.

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Introduction: Mapping and ablation through the coronary venous system (CVS) have shown potential for ventricular arrhythmias originating from the left ventricular summit (LVS). Multielectrode catheters and balloons are frequently used for mapping and venous ethanol ablation (VEA). However, there is limited data on the venous size and drainage condition in the LVS region.

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Elevated neurofilament light chain (NfL) levels have been associated with dementia in idiopathic Parkinson's disease (iPD). To examine the baseline and longitudinal changes in NfL levels in GBA-PD, SNCA-PD, and LRRK2-PD and further investigate the association between these genetic mutations, NfL, and dementia in PD. We analyzed data from the Parkinson's Progression Markers Initiative (PPMI), including 184 healthy controls (HC) and 617 PD categorized as iPD (n = 381), LRRK2-PD (n = 142), GBA-PD (n = 76) and SNCA-PD (n = 18).

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Background: Noninvasive fetal RHD genotyping has been provided to nonimmunized RhD-negative pregnant women to guide anti-D prophylaxis. Among the Chinese, more than 30% of the RhD-negative phenotype is associated with variant RHD alleles, which would limit the accuracy of fetal RHD status prediction; thus, more targeting and proper programs need to be developed.

Study Design And Methods: Fluorescence quantitative polymerase chain reaction PCR (qPCR) or Sanger sequencing on all RHD exons was used to detect maternal RHD genotypes.

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As global climate conditions continue to change, disturbance regimes and environmental drivers will continue to shift, impacting global vegetation dynamics. Following a period of vegetation greening, there has been a progressive increase in remotely sensed vegetation browning globally. Given the many societal benefits that forests provide, it is critical that we understand vegetation dynamic alterations.

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