Gallic acid-grafted chitosan photothermal hydrogels functionalized with mineralized copper-sericin nanoparticles for MRSA-infected wound management.

The management of wounds infected with drug-resistant bacteria represents a significant challenge to public health globally. Nanotechnology-functionalized photothermal hydrogel with good thermal stability, biocompatibility and tissue adhesion exhibits great potential in treating these infected wounds. Herein, a novel photothermal hydrogel (mCS-Cu-Ser) was prepared through in situ mineralization in the hydrogel networks and ion cross-linking driven by copper ions (∼3 mM).

Lotus-inspired cellulose-based aerogel with Janus wettability and vertically aligned vessels for salt-rejecting solar seawater purification.

High-performance solar interface evaporators provide a promising, sustainable, and cost-effective solution to the global freshwater crisis through seawater purification. However, achieving a delicate balance between maximizing the evaporation rate and ensuring continuous, stable, and durable operation presents a critical challenge. Herein, we present a biomimetic cellulose/polypyrrole-coated silica/graphene evaporator with self-assembled nanofiber networks and vertically aligned vessels for enhanced salt resistance.

Designing mechanically robust one-component nanocomposites via hyperbranched cellulose nanofibril grafted vegetable oil polymers.

Achieving effective interfacial compatibility between hydrophilic cellulose nanofibrils (CNFs) and hydrophobic vegetable oil polymers (VOPs) remained a significant challenge. To address this issue, we developed a one-component nanocomposite (OCN) based on hyperbranched CNF-grafted VOPs. Rigid precursor initiator poly (vinylbenzyl chloride) (PVBC) was first grafted onto the CNF surface via phase-transfer catalysis, forming a branched macroinitiator (CNF-g-PVBC) with chlorine contents ranging from 4.

Lessons Learned From Characterizing Long COVID Among US Medicare Beneficiaries.

Purpose: To characterize long-term effects of COVID-19 among older adults (aged ≥ 65 years).

Methods: This retrospective descriptive study utilized Medicare Fee-for-Service beneficiaries' claims to characterize post-COVID condition diagnosis code usage, long COVID (defined as post-COVID condition diagnoses made ≥ 28 days after an initial COVID-19 diagnosis) incidence, patient demographics, and concurrent diagnoses.

Results: During April 1, 2020 to May 21, 2022, 193 691 (0.

[Clinical observation on rapid relief of dyspnea in juvenile-onset recurrent respiratory papillomatosis treated with bevacizumab].

To evaluate the efficacy of bevacizumab in reducing dyspnea, avoiding tracheostomy, and assessing the overall safety and effectiveness of the treatment in patients with juvenile-onset recurrent respiratory papillomatosis (JORRP). This study included 19 patients with JORRP treated with Bevacizumab at the Department of Otolaryngology-Head and Neck Surgery, BenQ Medical Center, from March 2022 to June 2024. The age of patients ranged from 1.

Network pharmacology alliance with experimental validation unveils the anti-colorectal cancer mechanism of Xianlian Jiedu decoction.

Ethnopharmacological Relevance: The Xianlian Jiedu Decoction (XLJDD), a traditional Chinese medicine (TCM) decoction, which is effective in clinical treatment of colorectal cancer (CRC). Nevertheless, the pharmacodynamic material basis and mechanism of its action have not been explored yet.

Aims Of The Study: To investigate the potential functional components and possible mechanism of XLJDD in anti-CRC.

Ribosomal protein L6 suppresses hepatocellular carcinoma by modulating FBXO22-mediated p53 degradation.

The ribosomal protein L6 (RPL6) is significant in the progression of different cancer types. However, its precise role in hepatocellular carcinoma (HCC) remains unclear. This research demonstrated that the expression levels of RPL6 are notably decreased in HCC tissues.

Ferritin to Transferrin Ratio: a new prognostic factor for renal cell carcinoma.

Objectives: To assess the prognostic value of the preoperative serum ferritin-to-transferrin ratio (FTR) in renal cell carcinoma (RCC). Methods：We retrospectively reviewed data from 226 patients who underwent surgery for non-metastatic RCC at our institution between January 1, 2012, and June 30, 2021. Time-dependent receiver operating characteristic (timeROC) analysis identified the optimal FTR cut-off, dividing patients into high and low FTR groups.

Identifying Neuro-inflammatory Biomarkers of Generalized Anxiety Disorder from Lymphocyte Subsets based on machine learning approaches.

Introduction: Activation of the inflammatory response system is involved in the pathogenesis of generalized anxiety disorder (GAD). The purpose of this study was to identify and characterize inflammatory biomarkers in the diagnosis of GAD based on machine learning algorithms.

Methods: The evaluation of peripheral immune parameters and lymphocyte subsets was performed on patients with GAD.

Slow sand filters with variable filtration rates for rainwater purification: Microecological differences between biofilm and water phases.

Slow sand filters (SSFs) have been increasingly applied to rainwater purification in recent years, but the response of SSFs to fluctuating rainfall, as well as the biofilm- and water-phase microecology in SSFs are still poorly understood. This study systematically evaluated the rainwater purification performance of SSFs and compared the bacterial community structure, assembly processes and molecular ecological interactions between the biofilm and water phases. The activated carbon and activated alumina filters exhibited the best performance for NH-N (18.

When multiple instance learning meets foundation models: Advancing histological whole slide image analysis.

Deep multiple instance learning (MIL) pipelines are the mainstream weakly supervised learning methodologies for whole slide image (WSI) classification. However, it remains unclear how these widely used approaches compare to each other, given the recent proliferation of foundation models (FMs) for patch-level embedding and the diversity of slide-level aggregations. This paper implemented and systematically compared six FMs and six recent MIL methods by organizing different feature extractions and aggregations across seven clinically relevant end-to-end prediction tasks using WSIs from 4044 patients with four different cancer types.

Evaluation of the genetic diversity and population structure of 5 pheasant breeds in Shanghai.

The genetics of pheasant breeds in Chinese farms has not been investigated yet. Understanding their genetic diversity and population structure is important for future advancements in pheasant breeding. In this study, the whole-genome resequencing was used to analyze a total of 352 samples from 5 pheasant species (American pheasant, White pheasant, Green pheasant, Shenhong pheasant, and Fengxian blue pheasant).

miRNA-125a regulates porcine oocyte maturation in vitro by targeting ADAR.

Follicular fluid extracellular vesicles are beneficial for in vitro oocyte maturation and development; however, their effect on the expression profiles of oocyte microRNAs (miRNAs) and the roles of related miRNAs are unknown. In this study, we aimed to investigate miRNA expression in mature oocytes cultured in follicular fluid extracellular vesicles and the effect of miRNA-125a (miR-125a) on oocyte maturation. The expression profiles of the miRNAs were determined by microRNA sequencing, followed by target gene prediction analysis.

Development of sensitive and rapid immunoassays for Moniliformin (MON) detection based on nanomaterials labeled monoclonal antibodies.

Moniliformin (MON) is a toxic secondary metabolite from Fusarium species. The natural contamination of MON in cereals and cereal by-products, poses a risk of exposure to MON. However, so far, no immunoassay method has been reported to detect MON in field samples.

Pulmonary nodule malignancy probability: a meta-analysis of the Brock model.

Aim: This study aims to quantify the performance of the Brock model through a systematic review and meta-analysis and to clarify its overall accuracy in predicting malignant pulmonary nodules.

Materials And Methods: A systematic search was conducted in databases including the Cochrane Library, Excerpta Medica database (EMBASE), MEDLINE, Web of Science, Chinese Biological Medicine Database (CBM), China National Knowledge Infrastructure (CNKI), VIP, and Wanfang from their inception until May 1, 2024, to collect observational cohort studies involving the Brock model. The primary outcome was the pooled area under the receiver operating characteristic curve (ROC) the area under curve (AUC) for the Brock model.

Toxicological effects of the environmental pollutant perfluoronanoic acid on the ground-dwelling arthropod Solenopsis invicta.

Perfluorononanoic acid (PFNA), widely employed in surfactants, coatings, plastics, corrosion inhibitors, and fire-extinguishing agents, is less regulated than PFOS or PFOA but displays higher bioaccumulation and potential toxicity. Most toxicity assessments have focused on mammals, fish, and algae, with limited research on ground-dwelling arthropods, especially ants. Here, we examined PFNA's toxic effects on red imported fire ants (RIFAs), a prevalent ground-dwelling species in South China.

Exploring the distribution and fate of bisphenol A in an aquatic microcosm combined with a multimedia model.

Bisphenol A (BPA), a well-known endocrine-disrupting chemical, has garnered significant attention in environmental science and policy. BPA can enter the aquatic environment through different routes, posing potential risks even at a low concentration. In this study, a four-compartment system [water, sediment, biota (zebrafish), and submerged aquatic vegetation (Vallisneria natans)] of a point source continuous discharge microcosm was established to investigate the distribution and fate of BPA in an aquatic microcosm.

Nanoscale interaction mechanism between bubbles and microplastics under the influence of natural organic matter in simulated marine environment.

Bubble-microplastic (MP) interaction is a significant process that changes the routes of MP circulation in marine environment and thereby determines the risk of MPs, which could be strongly influenced by natural organic matter (NOM) in oceans. However, the quantitative interaction mechanisms between bubbles and MPs under the effect of NOM remain elusive. Herein, bubble-MP interactions in simulated seawater were quantified at nanoscale based on atomic force microscope coupled with the Stokes-Reynold-Young-Laplace model.

Evaluation of the inhibitory effect of different molecular weights chitosan on MRGPRX2-mediated mast cell degranulation and the pseudo-allergic reaction.

Objectives: Chitosan is widely used in medicine to regulate immune responses in T cells and dendritic cells. However, research on the regulation of mast cells (MCs) is scarce. Mas-related G-protein-coupled receptor X2 (MRGPRX2) is a key receptor that mediates MC activation.

Imaging Electron Beam-Sensitive Twisted Hybrid Perovskite Bilayers at One-Angstrom Resolution.

Twisted halide perovskite bilayers, a type of moiré material, show square moiré patterns with exciting optical properties. Atomic-scale structure analysis and its correlation with properties are difficult to achieve due to the extreme sensitivity of organic-inorganic halide perovskites to the illuminated electron beam in conventional/scanning transmission electron microscopy. Here, we developed a low-dose exit wave reconstruction methodology with a real-space resolution of one angstrom at ∼50 e/Å, which recovers the phase information on the moiré fringes in CHNHPbI (MAPbI) twisted perovskite bilayers at atomic scale, enabling detailed structural analysis of defects and corresponding strain distribution in such moiré materials.

Fabrication of Z-Scheme MIL-125/Ag/BiOBr Heterojunctions with Enhanced Photocatalytic Reduction of Cr.

Herein, first, MIL-125 samples were synthesized via a hydrothermal method. Then, Ag species were doping on the surface of MIL-125 samples via the photolysis of silver nitrate. Finally, the Z-scheme MIL-125/Ag/BiOBr composite was synthesized via a directed liquid assembly method.

Ergothioneine, a New Acrolein Scavenger at Elevated Temperature.

Acrolein (ACR) present in vivo and in vitro can damage proteins and DNA, linking it to various chronic diseases. In this paper, ergothioneine (EGT), abundant in edible mushrooms, has been studied for its ability to trap ACR and its reaction pathway with ACR at high temperatures using ultraperformance liquid chromatography-mass spectrometry (UPLC-MS/MS). We synthesized the adducts (EGT-ACR-1 and EGT-ACR-2), elucidating their structure and reaction site through HRMS and nuclear magnetic resonance.

Mitochondria complex III-generated superoxide is essential for IL-10 secretion in macrophages.

Mitochondrial electron transport chain (ETC) function modulates macrophage biology; however, mechanisms underlying mitochondria ETC control of macrophage immune responses are not fully understood. Here, we report that mutant mice with mitochondria ETC complex III (CIII)-deficient macrophages exhibit increased susceptibility to influenza A virus (IAV) and LPS-induced endotoxic shock. Cultured bone marrow-derived macrophages (BMDMs) isolated from these mitochondria CIII-deficient mice released less IL-10 than controls following TLR3 or TLR4 stimulation.

Discovery of Fluorescent Probe ABDS-2 for Farnesoid X Receptor Modulator Characterization and Cell-Based Imaging.

The farnesoid X receptor (FXR) regulates key physiological processes, such as bile acid homeostasis and lipid metabolism, making it an important target for drug discovery. However, the overactivation of FXR often leads to adverse effects. This study presents the development of a novel fluorescent probe utilizing the computer-aided drug design (CADD) approach to optimize linkers between more potent warhead and FITC fluorescent groups.