Anti-inflammatory and Antiphytopathogenic Fungal Activity of 2,3--Tirucallane Triterpenoids Meliadubins A and B from Cav. Barks with ChemGPS-NP and In Silico Prediction.

Two new rearranged 2,3--tirucallane triterpenoids, meliadubins A () and B (), along with four known compounds, -, were isolated from the barks of Cav. Compound exhibited a significant inflammatory inhibition effect toward superoxide anion generation in human neutrophils (EC at 5.54 ± 0.

Bioactive polyketides from the pathogenic fungus of Epicoccum sorghinum.

We discovered and identified a series of characteristic substances, including one new polyketide, epicorepoxydon B, of the important pathogenic fungus, Epicoccum sorghinum, of sorghum. The fungal extract and some isolated polyketides are sensitive to a malignant triple-negative breast cancer cell line, MDA-MB-231. Sorghum (Kaoliang) grain is an important crop with high economic value and several applications.

Anti-inflammatory, Antiplatelet Aggregation, and Antiangiogenesis Polyketides from : Toward an Understating of Its Biological Activities and Potential Applications.

The ethyl acetate extract of an endophyte exhibited anti-inflammatory activity at a concentration of <10 μg/mL. By bioassay-guided fractionation, one new compound, named epicorepoxydon A (), and one unusual bioactive compound, 6-(hydroxymethyl)benzene-1,2,4-triol (), together with six known compounds, were isolated from . The structures of all isolates were established by spectroscopic analyses.

Prediction of protein essentiality by the support vector machine with statistical tests.

Essential proteins include the minimum required set of proteins to support cell life. Identifying essential proteins is important for understanding the cellular processes of an organism. However, identifying essential proteins experimentally is extremely time-consuming and labor-intensive.