Neuroticism and posttraumatic stress disorder: A Mendelian randomization analysis.

Objective: Epidemiological studies revealed an unestablished association between neuroticism and posttraumatic stress disorder (PTSD) and we conducted mendelian randomization (MR) analyses to examine whether neuroticism clusters of worry, depressed affect, and sensitivity to environmental stress and adversity (SESA) were involved in the development of PTSD.

Method: We obtained data on three neuroticism clusters, PTSD, and nine other psychiatric disorders from genome-wide association studies summary statistics and employed univariable, multivariable, and mediation MR analyses to explore causal associations among them.

Results: Neuroticism clusters were linked with PTSD (depressed affect (odds ratio [OR]: 2.

Decoding and Systematization of Medical Imaging Features of Multiple Human Malignancies.

Purpose: To summarize the data of previously reported medical imaging features on human malignancies to provide a scientific basis for more credible imaging feature selection for future studies.

Materials And Methods: A search was performed in PubMed from database inception through March 23, 2018, for studies clearly stating the decoding of medical imaging features for malignancy-related objectives and/or hypotheses. The Newcastle-Ottawa scale was used for quality assessment of the included studies.