Publications by authors named "Zidan Qiu"
In our prior research, it was noted that slit guidance ligand 3 (SLIT3), a member of the SLIT-secreted protein family, may play a potential role in tumorigenesis. In addition, our prior work has found that the SLIT3 gene is highly methylated, especially in advanced-stage lung cancer tissues. Herein, we propose the hypothesis that abnormal SLIT3 expression may be linked to lung cancer development.
View Article and Find Full Text PDFBreast cancer (BCA) is one of the most prevalent cancers among women. Emerging evidence has revealed that Annexin A-9 (ANXA9) plays a crucial function in the development of some cancers. Notably, ANXA9 has been reported to be a new prognostic biomarker for gastric and colorectal cancers.
View Article and Find Full Text PDFArticle Synopsis
- - Trastuzumab emtansine (T-DM1) is an antibody-drug conjugate (ADC) that targets cancer cells, and this study reveals that critical quality attributes like drug to antibody ratio (DAR) and site conjugation ratios show surprising consistency contrary to the belief that conjugation is random at lysine sites.
- - The research involved analyzing 27 conjugation sites and found strong correlations (≥ 0.9) between the site conjugation ratios and DAR, indicating that conjugation characteristics may remain stable under controlled manufacturing conditions.
- - Additionally, the study identified four types of unconjugated linker byproducts from the ADC production process, contributing valuable insights for improving ADC processing, ensuring product quality, and minimizing
The aim of the present study was to investigate the ability of Nimotuzumab to increase radiosensitivity at different delivery times in the mixed cancer cell line Eca109, to determine the optimal delivery time. Cultured Eca109 cells were classified into five groups: Control with no treatment (O group); irradiation without Nimotuzumab treatment (R group); treatment with Nimotuzumab 24 h prior to or after irradiation (24NR or 24RN group, respectively); and Nimotuzumab combined with irradiation simultaneously (NR group). Following cells reaching the logarithmic-growth phase, cell survival after exposure to Nimotuzumab was evaluated using an MTT assay; thereafter, the 50% inhibitory concentration (IC) of the cell line was calculated.
View Article and Find Full Text PDFObjective: To separate/enrich tumor stem-like cells from the human esophageal carcinoma cell line OE-19 by using serum-free suspension culture and to identify their biological characteristics and radiation resistance.
Methods: OE-19 cells were cultivated using adherent and suspension culture methods. The tumor stem-like phenotype of CD44 expression was detected using flow cytometry.
Article Synopsis
- The study focuses on the role of the epidermal growth factor receptor (EGFR) signaling pathway in esophageal squamous cell carcinoma (ESCC) and how related proteins (EGFR, c-Fos, c-erb-B2) are expressed in tumor samples.
- Findings show that over 70% of tumors expressed EGFR, with positivity linked to higher tumor stages and metastasis; c-Fos was found in 85% of tumors, and its expression also correlated with tumor depth.
- The study concludes that high levels of EGFR, c-Fos, and c-erb-B2 are associated with tumor progression, indicating that these proteins could serve as important prognostic factors for assessing tumor stage and invasion in ES