Nucleus-targeted Silencer nanoplatform regulating ZEB1-AS1 in head and neck squamous cell carcinoma therapy.

Long noncoding RNAs have emerged as key players in the progression of head and neck squamous cell carcinoma (HNSC). Among them, ZEB1-AS1 was identified as an upregulated candidate in HNSC through comprehensive analysis of RNA-sequencing datasets. Here, elevated ZEB1-AS1 expression was correlated with poor prognosis in HNSC patients.

Continuous-variable quantum key distribution robust against environmental disturbances.

Continuous variable quantum key distribution (CV-QKD) can guarantee that two parties share secure keys even in the presence of an eavesdropper. However, the polarization direction of the coherent state transmitted in CV-QKD is susceptible to environmental disturbances during channel transmission, making it difficult to share keys consistently over long periods of time. Therefore, a CV-QKD system that can resist environmental disturbance is very urgent.

Synthesis of FeOOH/Zn(OH)/CoS Ferromagnetic Nanocomposites and the Enhanced Mechanism of Magnetic Field for Their Electrochemical Performances.

The FeOOH/Zn(OH)/CoS (FZC) nanocomposites are synthesized and show the outstanding electrochemical properties in both supercapacitor and catalytic hydrogen production. The specific area capacitance reaches 17.04 F cm, which is more than ten times higher than that of FeOOH/Zn(OH) (FZ) substrate: 1.

Polystyrene microplastics induce size-dependent multi-organ damage in mice: Insights into gut microbiota and fecal metabolites.

Particle size is one of the most important factors in determining the biological toxicity of microplastics (MPs). In this study, we attempted to examine the systemic toxicity of polystyrene MPs of different sizes (0.5 µm MP1 and 5 µm MP2) in C57BL/6 J mice.

Regulating the HO Activation Pathway on a Well-Defined CeO Nanozyme Allows the Entire Steering of Its Specificity between Associated Enzymatic Reactions.

Nanozymes are promising alternatives to natural enzymes, but their use remains limited owing to poor specificity. For example, CeO activates HO and displays peroxidase (POD)-like, catalase (CAT)-like, and haloperoxidase (HPO)-like activities. Since they unavoidably compete for HO, affecting its utilization in the target application, the precise manipulation of reaction specificity is thus imperative.

Polynitrosoarene Radical as an Efficient Cathode Material for Lithium-Ion Batteries.

Organic radical batteries (ORBs) with radical-branched polymers as cathode materials represent a valuable alternative to meet the continuously increasing demand on energy storage. However, the low theoretical capacities of current radical-contained compounds strongly hamper their practical applications. To address this issue, a chemically robust polynitrosoarene (tris(4-nitrosophenyl)amine) with a pronounced radical property is rationally designed as an efficient cathode for ORBs.

Facet-Dependent Activity of CeO Nanozymes Regulate the Fate of Human Neural Progenitor Cell via Redox Homeostasis.

Neural progenitor cells (NPCs) therapy, a promising therapeutic strategy for neurodegenerative diseases, has a huge challenge to ensure high survival rate and neuronal differentiation rate. Cerium oxide (CeO) nanoparticles exhibit multienzyme mimetic activities and have shown the capability of regulating reactive oxygen species (ROS), which is a pivotal mediator for intracellular redox homeostasis in NPCs, regulating biological processes including differentiation, proliferation, and apoptosis. In the present study, the role of facet-dependent CeO-mediated redox homeostasis in regulating self-renewal and differentiation of NPCs is reported for the first time.

Unravelling the Role of Structural Geometry and Chemical State of Well-Defined Oxygen Vacancies on Pristine CeO for HO Activation.

Although HO has been often employed as a green oxidant for many CeO-catalyzed reactions, the underlying principle of its activation by surface oxygen vacancy (V) is still elusive due to the irreversible removal of postgenerated V by water (or HO). The metastable V (ms-V) naturally preserved on pristine CeO surfaces was adopted herein for an in-depth study of their interplay with HO. Their well-defined local structures and chemical states were found facet-dependent affecting both the adsorption and subsequent activation of HO.

Chemical state tuning of surface Ce species on pristine CeO with 2400% boosting in peroxidase-like activity for glucose detection.

We demonstrate that the Ce reactivity of CeO towards HO is dictated by its local structure and electron density. More than 2400% increase in peroxidase-like activity has been achieved on the (100) surface for glucose detection due to the promoted HO adsorption and subsequent activation by the electron-rich Ce species.

Nanoisozymes: The Origin behind Pristine CeO as Enzyme Mimetics.

It is known that the interplay between molecules and active sites on the topmost surface of a solid catalyst determines its activity in heterogeneous catalysis. The electron density of the active site is believed to affect both adsorption and activation of reactant molecules at the surface. Unfortunately, commercial X-ray photoelectron spectroscopy, which is often adopted for such characterization, is not sensitive enough to analyze the topmost surface of a catalyst.

LncRNA THOR promotes tongue squamous cell carcinomas by stabilizing IGF2BP1 downstream targets.

THOR, a highly conserved lncRNA, is potentially involved in various cancer development. However, its involvement in tongue squamous cell carcinoma (TSCC) remains unclear. The present study aims to explore the biological function and molecular mechanism of THOR in TSCC progression.

Leaching variations of heavy metals in chelator-assisted phytoextraction by Zea mays L. exposed to acid rainfall.

Chelant-enhanced phytoextraction method has been put forward as an effective soil remediation method, whereas the heavy metal leaching could not be ignored. In this study, a cropping-leaching experiment, using soil columns, was applied to study the metal leaching variations during assisted phytoextraction of Cd- and Pb-polluted soils, using seedlings of Zea mays, applying three different chelators (EDTA, EDDS, and rhamnolipid), and artificial rainfall (acid rainfall or normal rainfall). It showed that artificial rainfall, especially artificial acid rain, after chelator application led to the increase of heavy metals in the leaching solution.