A microneedle patch realizes weight loss through photothermal induction of fat browning.

As a globally prevalent disease, obesity leads to many chronic diseases, so it is important to develop safe and effective treatments with fewer side effects and lasting weight loss. In this study, we developed a biodegradable hyaluronic acid microneedle patch loaded with polydopamine nanoparticles and mirabegron, which directly acted on subcutaneous white adipose tissue, and then induced browning of white adipose tissue through mild photothermal therapy. The approach showed excellent browning-promoting ability and biocompatibility.

Gelatin/calcium chloride electrospun nanofibers for rapid hemostasis.

Blood coagulation is the body's main defense to bleeding caused by trauma and is divided into endogenous and exogenous pathways. Calcium ions play a very important role in the process of blood coagulation, as the ions activate the many enzymes that are required for coagulation. In this paper, gelatin hemostatic membranes containing calcium ions were prepared by electrospinning.

Inhibitory effects of sweet cherry anthocyanins on the obesity development in C57BL/6 mice.

In the present study, purified sweet cherry anthocyanins (CACN) were evaluated to determine their inhibitory effects on adipocyte differentiation of 3T3-L1 cells and their anti-obesity properties in male C57BL/6 mice fed with high-fat diet (HFD). CACN prevented HFD-induced obesity in C57BL/6 mice. In vivo experiment revealed that 40 and 200 mg/kg of CACN in food reduced the body weight by 5.

Blueberry and mulberry juice prevent obesity development in C57BL/6 mice.

Objectives: To establish whether blueberry (Vaccinium ashei) and mulberry (Morus australis Poir) juice, anthocyanin rich fruit juice, may help counteract obesity.

Design: And Methods: Four-week-old C57BL/6 mice were fed a high-fat diet (HFD) with or without blueberry and mulberry juice for 12 weeks. Body weight, serum and hepatic lipids, liver and adipose tissues morphology, insulin and leptin were assessed.

Honeysuckle anthocyanin supplementation prevents diet-induced obesity in C57BL/6 mice.

This study investigated the anti-obesity effects of honeysuckle anthocyanins (HA) in a high fat diet-induced mouse model. The mice were initially fed with a low-fat diet (LFD) or high-fat diet (HFD) for 8 weeks. After that, the HFD-fed mice were divided into five groups, with 12 mice in each group, including a HFD group, a HFD plus Orlistat group, and three HFD plus HA (at a dose of 50, 100, or 200 mg kg(-1)) groups, for another 8-week experiment.