Nerve-Inspired Optical Waveguide Stretchable Sensor Fusing Wireless Transmission and AI Enabling Smart Tele-Healthcare.

Flexible strain monitoring of hand and joint muscle movement is recognized as an effective method for the diagnosis and rehabilitation of neurological diseases such as stroke and Parkinson's disease. However, balancing high sensitivity and large strain, improving wearing comfort, and solving the separation of diagnosis and treatment are important challenges for further building tele-healthcare systems. Herein, a hydrogel-based optical waveguide stretchable (HOWS) sensor is proposed in this paper.

Environmentally Relevant Levels of Antiepileptic Carbamazepine Altered Intestinal Microbial Composition and Metabolites in Amphibian Larvae.

There is growing concern about the potential ecological risks posed by pharmaceutical residues in the aquatic environment. However, our understanding of the toxic effects of antiepileptic pharmaceuticals, such as carbamazepine (CBZ), on aquatic animal larvae is still limited. In this study, the tadpoles of the black-spotted pond frog () were exposed to environmentally relevant concentrations of CBZ (0.

Air Pollutants and Risk of Parkinson's Disease among Women in the Sister Study.

Background: Air pollutants may contribute to the development of Parkinson's disease (PD), but empirical evidence is limited and inconsistent.

Objectives: This study aimed to prospectively investigate the associations of PD with ambient exposures to fine particulate matter with aerodynamic diameter () and nitrogen dioxide ().

Methods: We analyzed data from 47,108 US women from the Sister Study, enrolled from 2003-2009 (35-80 years of age) and followed through 2018.

Polygenic risk score for Parkinson's disease and olfaction among middle-aged to older women.

Introduction: Olfactory impairment and Parkinson's disease (PD) may share common genetic and environmental risk factors. This study investigates the association of a PD polygenic risk score (PRS) with olfaction, and whether the associations are modified by environmental exposures of PM, NO, or smoking.

Methods: This analysis included 3358 women (aged 50-80) from the Sister Study with genetic data and results from the Brief Smell Identification Test (B-SIT) administered in 2018-2019.

Ambient Air Pollutants and Olfaction among Women 50-79 Years of Age from the Sister Study.

Background: Poor olfaction is common in older adults and may have profound adverse implications on their health. However, little is known about the potential environmental contributors to poor olfaction.

Objective: We investigated ambient fine particulate matter [PM in aerodynamic diameter ()] and nitrogen dioxide () in relation to poor olfaction in middle-aged to older women.

Parkinson's Disease Case Ascertainment in the Sister Study: A Cohort for Environmental Health Research.

Background: Large prospective studies are essential for investigating the environmental causes of Parkinson's disease (PD), but PD diagnosis via clinical exams is often infeasible in such studies.

Objective: To present case ascertainment strategy and data collection in a US cohort of women.

Methods: In the Sister Study (n = 50,884, baseline ages 55.

Assessment of Self-reported Sense of Smell, Objective Testing, and Associated Factors in Middle-aged and Older Women.

Importance: Poor olfaction is common in older adults and signifies multiple adverse health outcomes, but it often goes unrecognized.

Objective: To characterize the self-awareness of poor olfaction in women, including its prevalence, associated factors, reporting reliability, validity against an objective test, and factors associated with validity.

Design, Setting, And Participants: These cross-sectional survey data and a case-control subsample were taken from the National Institute of Environmental Health Sciences' Sister Study.

Diffusion Tensor Imaging of the Olfactory System in Older Adults With and Without Hyposmia.

To compare gray matter microstructural characteristics of higher-order olfactory regions among older adults with and without hyposmia. Data from the Brief Smell Identification Test (BSIT) were obtained in 1998-99 for 265 dementia-free adults from the Health, Aging, and Body Composition study (age at BSIT: 74.9 ± 2.

Self-Reported Versus Objectively Assessed Olfaction and Parkinson's Disease Risk.

Background: Poor olfaction is a prodromal symptom of Parkinson's disease (PD); however, self-reported sense of smell is often dismissed as unreliable.

Objective: To assess self-reported and objectively assessed sense of smell, independently and jointly, in relation to future risk for PD.

Methods: We conducted a prospective analysis using data from 2,424 participants, ages 71-82 at baseline, from the Health, Aging, and Body Composition study.