Publications by authors named "Zicheng Tan"
Article Synopsis
- The study focuses on the role of DYRK1 kinase in notochord development and lumen formation in ascidians, revealing that blocking its activity impairs these processes.
- Through phosphoproteomics, researchers identified 1,065 notochord-specific phosphoproteins, with 428 that were differently phosphorylated upon DYRK1 inhibition, highlighting their involvement in vital cellular functions.
- Further analysis demonstrated that mutations in specific phosphosites of key protein families (like SLC, RAB, and TJP) led to defects in lumen formation, indicating the importance of phosphorylation in regulating cellular processes related to notochord development.
Lumen formation and inflation are crucial steps for tubular organ morphogenesis, yet the underling mechanism remains largely unrevealed. Here, we applied 4D proteomics to screen the lumenogenesis-related proteins and revealed the biological pathways potentially that are involved in lumen inflation during notochord lumen formation in the ascidian Ciona savignyi. In total, 910 differentiated expressed proteins (DEPs) were identified before and after notochord lumen formation utilizing Mfuzz analysis.
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