Publications by authors named "Zichen Liu"

Perovskite materials have wide application prospects in many fields due to their tunable and designable band gap characteristics. Machine learning has obvious advantages in quickly and effectively discovering new materials. However, noise interference within data sets frequently hinders the ability of traditional predictive and evaluative techniques to satisfy practical requirements.

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Background And Objectives: Enarodustat is a hypoxia-inducible factor-prolyl hydroxylase inhibitor. We evaluated the pharmacokinetics, pharmacodynamics, and safety profile of domestic enarodustat (SAL-0951) and analyzed the influence of ethnic factors.

Methods: In this phase I study, healthy Chinese participants received single and multiple oral doses (1, 5, and 15 mg) of SAL-0951 while in a fasted state.

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Tuberculosis (TB), caused by (Mtb), is the deadliest single-agent infection worldwide. Current antibiotic treatment for TB takes a minimum of four months, underscoring the need for better therapeutics. The unique mycobacterial cell envelope, particularly the outermost mycomembrane, has long been thought to promote intrinsic antibiotic resistance by limiting compound entry into Mtb.

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Gram-negative bacterial pathogens pose a significant challenge in drug development due to their outer membranes, which impede the permeation of small molecules. The lack of widely adoptable methods to measure the cytosolic accumulation of compounds in bacterial cells has hindered drug discovery efforts. To address this challenge, we developed the CHloroalkane Azide Membrane Permeability (CHAMP) assay, specifically designed to assess molecule accumulation in the cytosol of Gram-negative bacteria.

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Introduction: Renal anemia is a common complication among patients with non-dialysis chronic kidney disease (ND-CKD), and there remains an unmet need for more efficient and convenient daily oral medications to improve patient outcomes. This study aimed to evaluate the efficacy and safety of enarodustat, a hypoxia-inducible factor-prolyl hydroxylase inhibitor, in treating anemia for ND-CKD patients.

Methods: This phase 3 study was conducted at 48 centers across China, enrolling 156 ND-CKD patients.

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The mycomembrane of mycobacteria has long been regarded as the primary barrier to the accumulation of molecules within these bacteria. Understanding accumulation beyond the mycomembrane of () is crucial for developing effective antimycobacterial agents. This study investigates two design principles commonly found in natural products and mammalian cell-permeable peptides - backbone -methylation and macrocyclization - aimed at enhancing accumulation.

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This study aimed to assess the efficacy and safety of a combination therapy of Allisartan Isoproxil 240 mg and Amlodipine 5 mg (ALI/AML) compared to AML 5 mg monotherapy in patients with mild-to-moderate essential hypertension. In this phase III, multicenter, double-blind, parallel-group, randomized controlled trial, patients aged 18-70 years with mean sitting systolic blood pressure (msSBP) between 140 and <180 mmHg and mean sitting diastolic blood pressure (msDBP) between 90 and <110 mmHg, following a 4-week treatment with AML 5 mg, were randomized 1:1 to receive either ALI/AML or AML once daily for 12 weeks. This 12-week double-blind period was followed by an open-label extension of ALI/AML treatment through week 52.

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The recalcitrance of to antibiotic treatment has been broadly attributed to the impermeability of the organism's outer mycomembrane. However, the studies that support this inference have been indirect and/or reliant on bulk population measurements. We previously developed the P eptidoglycan A ccessibility C lick- M ediated A ssessme N t (PAC-MAN) method to covalently trap azide-modified small molecules in the peptidoglycan cell wall of live mycobacteria, after they have traversed the mycomembrane.

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Objective: Assessing the accuracy of automated EasyNAT system for rapidly detecting paraffin-embedded tissue for the diagnosis of tuberculosis.

Methods: A retrospective analysis was conducted on 134 patients, comprising 101 with confirmed tuberculosis and 33 without tuberculosis, treated at Beijing Chest Hospital, Capital Medical University, between 2018 and 2022.The clinical diagnostic results served as the standard for assessing the diagnostic performance of the EasyNAT system in comparison to quantitative real-time polymerase chain reaction (qPCR) for tuberculosis detection in paraffin-embedded tissues.

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Beam-steered infrared (IR) light communication has gained tremendous attention as one of the solutions of congested wireless communication traffic. High performance active beam-steering devices play a crucial role in data allocation and exchange. Conventional beam-steering devices such as spatial light modulator (SLM) and micro-electrical mechanical system (MEMS) mirror and the current emerging nonmechanical beam-steering metasurface-based devices are challenging to realize a large tunable steering angle beyond several degrees, which significantly hinders the spatial application of optical wireless communications (OWC).

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Purpose: To report outcomes of a 3-fraction HDR brachytherapy boost for the treatment of locally advanced cervical cancer (LACC) at a large safety net hospital.

Methods And Materials: A retrospective review of 93 patients with FIGO 2018 Stage IA2 to IVB cervical cancer treated with HDR brachytherapy boost in 3 fractions between 2017 and 2022 was conducted. The 2-year local control (LC), progression-free survival (PFS), and overall survival (OS) was estimated using Kaplan-Meier estimators.

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Article Synopsis
  • The giant panda, an emblem of biodiversity conservation, is threatened by the canine distemper virus (CDV), making the vaccination of domestic dogs in their habitats essential.
  • A study of 69 domestic dogs showed that vaccinated dogs can shed the virus starting nine days after vaccination, with unvaccinated dogs also at risk of increased antibody levels and viral shedding.
  • To protect giant pandas, it’s recommended that vaccinated dogs have restricted activity for at least three weeks post-vaccination, alongside collaboration among local authorities and community members for better management of domestic dog vaccinations.
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High-capacity optical interconnects with short reach are hugely demanded driven by the exponential growth of data traffic. In this work, four-channel wavelength division multiplexing (WDM) uplink/downlink twin single-sideband (twin-SSB) signals are implemented by a wavelength selective switch (WSS) at once, which simplifies the structure of multi-channel SSB transmitters and reduces the cost of high-capacity optical interconnect. Compared to a double sideband scheme, it has been experimentally proven that the performance of SSB transmission over standard single-mode fiber (SSMF) at C-band with an ultra-high baud rate has been greatly improved, which has the ability to effectively overcome the power fading induced by chromatic dispersion in an intensity modulation and direct detection (IM/DD) system.

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In recent years, initiatives aimed at mitigating eutrophication have successfully reduced nitrogen and phosphorus concentrations in numerous lakes across China. Notably, the management of total nitrogen levels has prompted a shift in the dominant genera responsible for harmful algal blooms. Among these, Dolichospermum, a typical diazotrophic cyanobacterium, exhibits the ability to differentiate heterocysts for atmospheric N fixation under nitrogen-limited conditions.

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ECG signals and sleep monitoring parameters complement each other and can be used for qualitative diagnosis of sleep apnea syndrome and cardio-related diseases. However, due to the limitations of the instrument volume and the detection environment, it is often challenging to integrate these two functions in practical applications. In this paper, a 12-lead dynamic electrocardiograph integrated with sleep monitoring is designed.

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This study describes two different doses of dexmedetomidine combined with tiletamine-zolazepam (TZ) for anesthesia in snow leopards (Panthera uncia). A total of 11 adult snow leopards were anesthetized in Xining City, Qinghai Province, China from November 2019 to June 2023. We recorded the onset time, anesthesia duration, head-up time, and walking time.

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Background: Tumor genomic profiling has a significant impact on the selection of targeted therapy. Circulating tumor DNA (ctDNA) has emerged as a noninvasive, and reproducible assay compared with tissue biopsy. We aimed to evaluate its utility in identifying mutations and guiding targeted therapy for lung cancer.

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Article Synopsis
  • Hypertension is a growing concern in China, with low control rates among patients, prompting a study on new treatment options.
  • A randomized trial compared the effectiveness and safety of sacubitril/allisartan vs. olmesartan in patients with mild-to-moderate hypertension over a 12-week period.
  • Results showed that sacubitril/allisartan significantly reduced blood pressure more than olmesartan, and it was well tolerated among participants, with no reports of serious side effects.
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The surging growth in data traffic has necessitated the development of higher-speed, lower-latency intensity modulation and direct detection (IM/DD) passive optical networks (PONs) with higher power budgets. To address the inherent limitations of traditional silica-based solid-core fibers, anti-resonant hollow-core fibers have garnered significant attention from both academia and industry. In this Letter, we present an experimental demonstration of 100 Gb/s PAM-4 IM/DD PON transmission over a 20 km anti-resonant hollow-core fiber in the C band, utilizing low-complexity digital signal processing (DSP).

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Understanding how the bacteriomes in tuberculous lesions can be influenced by the susceptibility of (MTB) can provide valuable information for preventing and treating drug resistant tuberculosis (DR-TB). High-throughput 16S rRNA sequencing was employed to analyze the bacteriome in pulmonary TB lesions from 14 patients with DR-TB and 47 patients with drug sensitive tuberculosis (DS-TB), along with 18 normal lung tissues (NT) from 18 lung cancer patients serving as the bacterial baseline. The phylogenetic investigation of communities by reconstruction of unobserved states2 (PICRUSt2) algorithm was utilized to predict bacterial metabolic functions.

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Introduction: In August 2021, an outbreak of Feline Panleukopenia Virus (FPV) was observed in four 3-month-old Pallas' cats at Xining Wildlife Park. Despite timely intervention, the Pallas'cat cubs continued to experience clinical symptoms including diarrhea, seizures, and decreased white blood cell count, and all four cats died.

Methods: FPV clinical suspicions were initially confirmed by positive Polymerase Chain Reaction (PCR) testing.

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Article Synopsis
  • The study investigates the effectiveness of cell-free Mycobacterium tuberculosis DNA (cf-TB) testing as a biomarker for diagnosing tuberculous pleurisy (TP) due to challenges with low bacterial levels in pleural effusion samples.
  • Conducted across 11 research sites in China, the study analyzed PE samples from 1344 patients suspected of TP, using techniques like Xpert MTB/RIF and mycobacterial culture alongside cf-TB testing.
  • Results revealed that cf-TB testing had a significantly higher sensitivity (73.6%) for definite TP compared to Xpert (40.8%) and mycobacterial culture (54.2%), while maintaining 100% specificity across all tests.
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Aims: To investigate the performance of a combined biomarker approach using the methylation status of the short stature homeobox 2 () and prostaglandin E2 receptor EP4 () genes, along with the serum levels of CYFRA21-1, for differential diganosis of malignant pleural mesothelioma (MPM) from benign reactive mesothelial hyperplasia (RMH).

Methods: We analysed 48 MPM tissue or pleural effusion cell block specimens and 42 cases with RMH. Real-time quantitative methylation-specific PCR was used to examine the methylation status of , , ras association domain family 1 isoform A, septin 9 gene and homeobox gene A9 genes.

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Canine oral melanoma is the most prevalent malignant tumor in dogs and has a poor prognosis due to its high aggressiveness and high metastasis and recurrence rates. More research is needed into its treatment and to understand its pathogenic factors. In this study, we isolated a canine oral mucosal melanoma (COMM) cell line designated as COMM6605, which has now been stably passaged for more than 100 generations, with a successful monoclonal assay and a cell multiplication time of 22.

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The intracameral injection of triamcinolone acetonide (TA) has achieved favorable clinical effects in controlling intraocular inflammatory reactions in humans after cataract surgery. However, the effect of this method remains unclear in veterinary practice. In this paper, 18 dogs with bilateral cataracts were randomly divided into three groups, with 6 dogs in each group.

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