Publications by authors named "Zichao Sui"
Objectives: This study aimed to quantitatively compare the efficacy and safety of long-acting β-agonist (LABA)/long-acting muscarinic antagonist (LAMA) and LABA/inhaled corticosteroid (ICS) fixed-dose combinations (FDCs) in preventing moderate or severe chronic obstructive pulmonary disease (COPD) exacerbations.
Methods: A literature search was performed using public databases. The time course characteristics of the probability of a moderate or severe exacerbation in stable COPD patients treated with LABA/LAMA and LABA/ICS FDCs were described by the parametric survival function.
Article Synopsis
- The study evaluates the effectiveness of various drugs and a placebo in treating primary progressive multiple sclerosis (PPMS) through a quantitative analysis of existing clinical trials.
- A total of 15 studies with 3779 patients were analyzed, identifying 12 drugs; while some drugs showed similar efficacy to placebo, others, particularly ocrelizumab, demonstrated significantly better outcomes.
- The findings contribute valuable data for informed clinical decisions regarding PPMS treatment and guide future clinical research.
Article Synopsis
- Neuromyelitis optica spectrum disorders (NMOSD) is a disease that affects the central nervous system and this study compared seven different drugs to see which one is most effective at preventing relapses.
- A total of 24 clinical trials involving 2207 patients were analyzed, focusing on the "time to first relapse" after treatment to determine the long-term effects of each drug.
- The results indicated that eculizumab was the most effective, with 98.9% of patients remaining relapse-free at 24 months, providing valuable data for future clinical practice and research.
Background: The GINA recommends inhaled corticosteroids (ICSs) for the treatment of steps 2-3 of childhood asthma. However, the difference in efficacy between these drugs remains unclear. The purpose of this study was to compare the efficacy of different ICS drugs in the treatment of childhood asthma.
View Article and Find Full Text PDFIntroduction: There is a wide variety of drugs for the clinical treatment of immunoglobulin A (IgA) nephropathy; however, previous studies have failed to clarify the quantitative differences in the efficacy of various drugs. In this study, we aimed to quantitatively compare the clinical efficacy of 6 classes of drugs with different pharmacological mechanisms for the treatment of IgA nephropathy and to identify relevant influencing factors.
Methods: Clinical trials of drugs for the treatment of IgA nephropathy were obtained from public databases.