Nuclear remodeling during cell fate transitions.

Totipotent stem cells, the earliest cells in embryonic development, can differentiate into complete embryos and extra-embryonic tissues, making them essential for understanding both development and regenerative medicine. This review examines recent advances in the dynamic remodeling of nuclear structures during the transition between totipotency and pluripotency, as well as other cell fate transition processes. Additionally, we highlight innovative experimental and computational methods that elucidate the relationship between nuclear architecture and cell fate decisions.

Design, synthesis, and biological evaluation of novel highly potent FXR agonists bearing piperidine scaffold.

Metabolic dysfunction-associated steatohepatitis (MASH) has become a serious threat to human health, which exhibited an increasing prevalence globally. Recently, the farnesoid X receptor (FXR) has been identified as a promising strategy for the treatment of MASH by regulating multiple pathogenesis. In this study, a new series of FXR agonists bearing piperidine scaffold was designed to reduce the high lipophilicity of the existing FXR agonists.

COP1-ERF1-SCE1 regulatory module fine-tunes stress response under light-dark cycle in Arabidopsis.

ETHYLENE RESPONSE FACTOR 1 (ERF1) plays an important role in integrating hormone crosstalk and stress responses. Previous studies have shown that ERF1 is unstable in the dark and its degradation is mediated by UBIQUITIN-CONJUGATING ENZYME 18. However, whether there are other enzymes regulating ERF1's stability remains unclear.

Plasmonic Bismuth Nanoparticles: Thiolate Pyrolysis Synthesis, Size-Dependent LSPR Property, and Their Oxidation Behavior.

Plasmonics, especially the localized surface plasmon resonance (LSPR) in non-noble metal bismuth nanoparticles (Bi NPs), and its spectral features and applications have stimulated increasing research interest in recent years. However, the lack of mature methods to prepare Bi NPs with a well-controlled size and/or shape significantly limits the experimental investigations concerning the LSPR optical properties. Herein, we realize the size-tunable synthesis of nearly monodisperse spherical Bi NPs through a thiolate pyrolysis reaction in solution.