Green Synthesis of FeO Nanoparticles Stabilized by a Fruit Peel Extract for Hyperthermia and Anticancer Activities.

Introduction: FeO nanoparticles (FeO NPs) with multiple functionalities are intriguing candidates for various biomedical applications.

Materials And Methods: This study introduced a simple and green synthesis of FeO NPs using a low-cost stabilizer of plant waste extract rich in polyphenols content with a well-known antioxidant property as well as anticancer ability to eliminate colon cancer cells. Herein, FeO NPs were fabricated via a facile co-precipitation method using the crude extract of fruit peel as a green stabilizer at different weight percentages (1, 2, 5, and 10 wt.

Polyethylene glycol-coated porous magnetic nanoparticles for targeted delivery of chemotherapeutics under magnetic hyperthermia condition.

Purpose: Although magnetite nanoparticles (MNPs) are promising agents for hyperthermia therapy, insufficient drug encapsulation efficacies inhibit their application as nanocarriers in the targeted drug delivery systems. In this study, porous magnetite nanoparticles (PMNPs) were synthesized and coated with a thermosensitive polymeric shell to obtain a synergistic effect of hyperthermia and chemotherapy.

Materials And Methods: PMNPs were produced using cetyltrimethyl ammonium bromide template and then coated by a polyethylene glycol layer with molecular weight of 1500 Da (PEG1500) and phase transition temperature of 48 ± 2 °C to endow a thermosensitive behavior.