Dendritic DNA/quantum dot nanostructure-based electrochemiluminescence biosensor for sensitive assay of Hg.

A novel dendritic DNA-quantum dot (QD) electrochemiluminescence (ECL) probe was developed and an ECL biosensor constructed for sensitive detection of Hg in water samples by combining with enzyme-assisted multiple cycle amplification strategy. Firstly, the Y-shaped structure was formed based on the Hg-induced enzymatic cycle amplification technique, which improved the cutting efficiency and realized the double-amplified DNA product. Moreover, a unique dendritic DNA nanostructure loading numerous QDs was constructed, which can greatly amplify the ECL signal.

Dual-signal fluorescence detection of miRNA based on nano-gold molecular beacon and in-situ generated silver nanoclusters coupled with multiple amplification.

In this work, a new dual-signal fluorescence strategy based on nano-gold molecular beacon (MB) and in-situ generated silver nano-clusters (NCs) coupled with multiple amplification technique was developed for sensitive detection of miRNA (let-7b). miRNA can recognize both hairpin probe (HP) and auxiliary DNA, inducing dual-cycle amplification-process to release plenty of DNA S2. As the report probe carboxyfluorescein (FAM) was modified on Au nanoparticles (AuNPs), the fluorescent signal was quenched due to the fluorescence resonance energy transfer (FRET).

Recent advancements in metal-organic framework-based aptasensors.

Metal-organic frameworks (MOFs), as a class of crystalline organic-inorganic hybrid materials, have demonstrated excellent performance in many fields, resulting in attracting more and more attention. Recently, MOFs have been widely used as functional materials to immobilize aptamers various interaction forces. The MOF-based aptasensors exhibit outstanding sensing performance, including high sensitivity, excellent selectivity, and good designability, by utilizing the advantages of MOFs and aptamers.

An AIE probe for simultaneous monitoring of endogenous and exogenous hypochlorite and Zn at dual channels in living cells.

Zn and ClO may be associated with a variety of pathologies, and their simultaneous measurement is crucial for disease diagnosis and environmental protection. In this work, we synthesized an independent AIE probe, HNTE, through a one step reaction. The probe HNTE displayed a distinctive fluorescence color change from deep yellow to blue for ClO and to green for Zn.

An AIE probe for the fluorescence and colorimetric sensing of La.

In this work, a fluorescent probe with aggregation-induced emission effect was synthesized by grafting naphtho[2,3-]furan-1,3-dione and 2-hydrazinylbenzo[]thiazole. The probe could recognize La selectively and sensitively accompanied with an obvious fluorescence and color change from green to blue. Moreover, with the help of AIE properties, probe N achieved the detection of La in the solid state.

Development of an AIE-active fluorescent probe for the simultaneous detection of Al and viscosity and imaging in Alzheimer's disease model.

Alzheimer's disease is associated both with imbalances in Al production and changes in viscosity in cells. Their simultaneous measurement could therefore provide valuable insights into Alzheimer's disease pathology. Their simultaneous measurement would therefore be of great value in investigating the pathological mechanism of Alzheimer's disease.

Enhanced CH/N Separation Efficiency of UiO-66-Br through Hybridization with Mesoporous Silica.

Efficient separation of CH from N is essential for the purification of methane from nitrogen. In order to address this problem, composite materials consisting of rod-shaped SBA-15-based UiO-66-Br were synthesized for the purpose of separating a CH/N mixture. The materials were characterized via PXRD, N adsorption-desorption, SEM, TEM, FT-IR, and TGA.

Integrating porphyrin-based nanoporous organic polymers with electrochemical aptasensors for ultratrace detection of kanamycin.

The synthesis and characterization of two new porphyrin-based porous organic polymers (POPs) via Sonogashira cross-coupling reaction and leverage the two obtained POPs is reported for the fabrication of electrochemical aptasensors to detect kanamycin at an ultratrace level. The resultant electrochemical aptasensor demonstrates a high linear relationship with the logarithmic value of kanamycin concentration in the range 5 × 10-5 μg/L with the limit of detection of 17.6 pg/L or 36.

A novel AIE material for sensing of Erythromycin in pure water by hydrogen bond in portable test strips and cellular imaging applications.

Erythromycin could be used to treat various bacterial infection, but it was harmful to the colonic microflora. Therefore, it is highly desirable to develop a fluorescence probe that could selectively and sensitively detect Erythromycin in pure water. In this work, a fluorescent probe named EHMC, which exhibited aggregation-induced emission (AIE) characteristic in solid state and water/EtOH binary solvent was developed for "turn on" sensing Erythromycin in pure water with high selectivity and sensitivity (detection limit: 1.

Recent Advances in Metal-Organic-Framework-Based Nanocarriers for Controllable Drug Delivery and Release.

Metal-organic frameworks (MOFs) have a good designability, a well-defined pore, stimulus responsiveness, a high surface area, and a controllable morphology. Up to now, various MOFs have been widely used as nanocarriers and have attracted lots of attention in the field of drug delivery and release because of their good biocompatibility and high-drug-loading capacity. Herein, we provide a comprehensive summary of MOF-based nanocarriers for drug delivery and release over the last five years.

Design of five two-dimensional Co-metal-organic frameworks for oxygen evolution reaction and dye degradation properties.

Two-dimensional (2D) metal-organic frameworks (MOFs) have been extensively investigated as oxygen evolution reaction (OER) materials because of their numerous advantages such as large specific surface areas, ultrathin thicknesses, well-defined active metal centers, and adjustable pore structures. Five Co-metal-organic frameworks, namely, [Co(L) (4.4'-bbidpe)HO] [YMUN 1 (YMUN for Youjiang Medical University for Nationalities)], {[Co(L) (4.

A Significant Fluorescence Turn-On Probe for the Recognition of Al and Its Application.

An easy prepared probe, , was designed and synthesized, which displayed a significant fluorescence enhancement (over 38-fold) and obvious color change in the recognition of Al. The binding ratio of probe to Al was determined as 1:1, according to Job plot. The binding mechanism was fully clarified by the experiments, such as FT-IR spectrum, ESI-MS analysis, and H NMR titration.

FASCIN regulates actin assembly for spindle movement and polar body extrusion in mouse oocyte meiosis.

During mouse oocyte meiotic maturation, actin filaments play multiple roles in meiosis such as spindle migration and cytokinesis. FASCIN is shown to be an actin-binding and bundling protein, making actin filaments tightly packed and parallel-aligned, and FASCIN is involved in several cellular processes like adhesion and migration. FASCIN is also a potential prognostic biomarker and therapeutic target for the treatment of metastatic disease.

A bifunctional fluorescent probe for sensing of Al and HS.

Al3+ and H2S play essential roles in various physiological processes. However, excess Al3+ and H2S are harmful to health. Therefore, it is necessary to design a sensitive method for the detection of Al3+ and H2S.

Highly Stable Acid-Induced Emission-Enhancing Cd-MOFs: Synthesis, Characterization, and Detection of Glutamic Acid in Water and Fe Ions in Acid.

Two novel 3D fluorescent metal-organic frameworks (MOFs), [Cd(L)(bbibp)] () and [Cd(L)(bbibp)] (), where HL = 4,4'-(4,4'-bipyridine-2,6-diyl)dibenzoic acid and bbibp = 4,4'-bis(benzoimidaz-1-yl)biphenyl, were acquired through a conventional method and characterized via IR spectra, single-crystal X-ray diffraction, elemental analysis, thermogravimetric analysis, powder X-ray diffraction (PXRD), scanning electron microscopy, N adsorption-desorption isotherms, and X-ray photoelectron spectroscopy (XPS). The crystal framework of Cd-MOF remained stable in the range of pH = 1.0-12.

Synthesis and characterization of MOFs constructed from 5-(benzimidazole-1-yl)isophthalic acid and highly selective fluorescence detection of Fe(iii) and Cr(vi) in water.

In this work, four novel metal-organic frameworks [Cd(bipa)] (1), {[Zn(bipa)]·2CHOH} (2), {[Co(bipa)]·CHOH} (3), {[Ni(bipa)]·2DMA} (4), (Hbipa = 5-(benzimidazole-1-yl)isophthalic acid) were successfully synthesized under solvothermal conditions. Complexes 1-4 were characterized by powder X-ray diffraction, elemental analysis, infrared spectroscopy and thermogravimetric analysis. Interestingly, the coordination patterns and 3D network structures of complexes 1-3 are very similar, while complex 4 is relatively unique.