Activation of kappa opioid receptor suppresses post-traumatic osteoarthritis via sequestering STAT3 on the plasma membrane.

Objective: Kappa opioid receptor (KOR) signaling is involved in joint development and inflammation in Osteoarthritis (OA), while the biochemical mechanism remains unclarified. This study aims to investigate downstream molecular events of KOR activation, to provide novel perspectives in OA pathology.

Methods: U50,488H, a selective KOR agonist, was intra-articularly injected in mice upon destabilization of the medial meniscus (DMM) as OA models, with PBS injection as control.

Results of radiological follow-up of untreated anterior disc displacement without reduction in adolescents.

Our aim was to assess the progression of disease without treatment in adolescents with non-reducible anterior disc displacement (ADD) using serial magnetic resonance images (MRI). We retrospectively reviewed all patients under the age of 20 years who had unilateral non-reducible ADD and had had two MRI during a period of 6 months with no intervention. A total of 124 patients (101 female and 23 male) with a mean (range) age of 16 (10-20) years had 2 MRI at least 6 months apart (mean (range) 14 (6-47) months).

Is anterior disc displacement without reduction associated with temporomandibular joint condylar height in juvenile patients younger than 20 years?

Purpose: Because disc displacement might be accompanied by degenerative changes in the condyle, this study explored the association between condylar height and anterior disc displacement without reduction in juvenile patients.

Materials And Methods: This was a retrospective cohort study that enrolled a sample of patients younger than 20 years with unilateral disc displacement without reduction. All patients had 2 magnetic resonance imaging records taken from January 2010 to June 2013 (interval, >6 months).

Pigmented villonodular synovitis of the temporomandibular joint with intracranial extension.

Pigmented villonodular synovitis is an uncommon benign tumor-like proliferative lesion with an undetermined origin. Involvement of the temporomandibular joint is uncommon. Although pigmented villonodular synovitis is a benign lesion, it can grow with an aggressive pattern, and it extends extra-articularly in most of the reported cases, about one-third of them exhibiting intracranial involvement.

Complete resection and immediate reconstruction with costochondral graft for recurrent aneurysmal bone cyst of the mandibular condyle.

Aneurysmal bone cyst is a non-neoplastic expansile lesion characterized by replacement with fibro-osseous tissue and blood-filled cavernous spaces. Involvement of the condyle is rare, and only 11 cases have been reported in English-language literature to date. Its common treatment modalities are lesion excision or condylar resection, but recurrence is high in patients treated with the former.