Publications by authors named "Ziang Zhou"

A 7-year-old boy underwent 18F-FDG PET/CT in the evaluation of a retroperitoneal mass. The examination revealed significant FDG accumulation in the right adrenal region and retroperitoneal lymph nodes, as well as mild FDG uptake in a diaphragmatic lesion. Histopathological analysis of the right adrenal mass was consistent with ganglioneuroblastoma.

View Article and Find Full Text PDF

In the context of wind energy systems, maintaining optimal power output in wind turbines when wind speeds exceed rated values necessitates precise regulation of blade pitch through the pitch control system. However, challenges in accurately modeling nonlinear control systems and enhancing control responsiveness arise due to factors such as actuator constraints, unmodeled dynamics, and random wind speed fluctuations. This paper proposes an improved model free control, termed Input Output Model Free Adaptive Control (IO-MFAC).

View Article and Find Full Text PDF

Purpose: Neuroblastoma (NB) is a malignant embryonic tumour with poor prognosis and high mortality rate. The antigen gisialoganglioside (GD2), which is highly expressed on the surface of NB cells, is an effective target for therapy. This study aims to evaluate the GD2 expression with [Cu]Cu-NOTA-hu3F8 positron emission tomography (PET) imaging and explore the radioimmunotherapy (RIT) effect of [Lu]Lu-DOTA-hu3F8 in NB tumour models.

View Article and Find Full Text PDF

Purpose: CD30 serves as an ideal therapeutic target for lymphoma, but its variable expression and high relapse rate pose challenges in targeted therapy. This study aims to label the anti-CD30 monoclonal antibody with Cu/Lu for immuno-positron emission tomography (immuno-PET) and radioimmunotherapy (RIT).

Methods: CD30 binding kinetics of anti-CD30-IgG (IMB16) were measured by Biolayer interferometry (BLI).

View Article and Find Full Text PDF

Disinfectants, such as bleaching powder, are widely employed in marine aquaculture worldwide to control the bacterial pathogens and eliminate antibiotic resistance genes (ARGs). Nevertheless, the rapid recovery of prokaryotic community compositions (PCCs) after disinfection may significantly influence the overall efficacy of disinfection. Presently, little is known about the rapid recovery mechanisms of PCCs and its impact on the removal of ARGs in seawater.

View Article and Find Full Text PDF

A phytochemical investigation of the ethanol extract from air-dried stems of Baccaurea ramiflora led to the isolation of four highly oxygenated picrotoxane-type sesquiterpenoids, ramifloraolides A - D (1-4). Their structures were elucidated by comprehensive spectroscopic data (HRESIMS, IR, 1D, and 2D NMR), and their absolute configuration of them were unambiguously determined by single-crystal X-ray diffraction. Structurally, all compounds possess a unique [4.

View Article and Find Full Text PDF
Article Synopsis
  • - Magnolol, a compound with anti-inflammatory properties, was studied for its ability to protect podocytes (key cells in the kidneys) from inflammation caused by high fructose consumption.
  • - In experiments with rats and human podocyte cell lines, magnolol improved kidney function and reduced the inflammatory markers TNF-α and NICD1, indicating its protective effects against fructose-induced damage.
  • - The study also examined how magnolol interacts with proteins involved in inflammation, showing that it affects the protein levels of TKFC, Sp1, and HDAC4, which play roles in the inflammatory response in podocytes.
View Article and Find Full Text PDF

Background: Podocytes have limited proliferative capacity, which leads to irreversible glomerular injury in diverse kidney diseases. Magnesium isoglycyrrhizinate (MgIG), a hepatoprotective agent in clinic, has been reported to improve glomerular podocyte injury. However, the underlying mechanism of MgIG in ameliorating podocyte injury remains unclear.

View Article and Find Full Text PDF
Article Synopsis
  • Neuroblastoma (NB) is a tricky cancer that can spread a lot and is different in many ways from person to person.
  • This study looked at 95 kids with NB to measure different factors related to the tumors using special scans (PET/CT) and tried to see if these measurements could help predict how well the kids would do in the future.
  • The results showed that two specific measurements from the whole-body tumors helped predict survival chances, while other measurements from the primary tumor were less helpful, indicating how important it is to understand the tumors fully.*
View Article and Find Full Text PDF

Background: The MYCN copy number category is closely related to the prognosis of neuroblastoma (NB). Therefore, this study aimed to assess the predictive ability of F-fluorodeoxyglucose (F-FDG) positron emission tomography/computed tomography (PET/CT) radiomic features for MYCN copy number in NB.

Methods: A retrospective analysis was performed on 104 pediatric patients with NB that had been confirmed by pathology.

View Article and Find Full Text PDF

Objectives: To develop and validate an 18F-FDG PET/CT-based clinical-radiological-radiomics nomogram and evaluate its value in the diagnosis of MYCN amplification (MNA) in paediatric neuroblastoma (NB) patients.

Methods: A total of 104 patients with NB were retrospectively included. We constructed a nomogram to predict MNA based on radiomics signatures, clinical and radiological features.

View Article and Find Full Text PDF

Determining the grade of glioma is a critical step in choosing patients' treatment plans in clinical practices. The pathological diagnosis of patient's glioma samples requires extensive staining and imaging procedures, which are expensive and time-consuming. Current advanced uniform-width-constriction-channel-based microfluidics have proven to be effective in distinguishing cancer cells from normal tissues, such as breast cancer, ovarian cancer, prostate cancer, etc.

View Article and Find Full Text PDF

Rationale And Objectives: To assess the predictive ability of an F-FDG PET/CT-based radiomics nomogram for bone marrow involvement in pediatric neuroblastoma.

Materials And Methods: A total of 241 neuroblastoma patients who underwent F-FDG PET/CT at two medical centers were retrospectively evaluated. Data from center A (n = 200) were randomized into a training cohort (n = 140) and an internal validation cohort (n = 60), while data from center B (n = 41) constituted the external validation cohort.

View Article and Find Full Text PDF

Background: This study sought to examine whether iodine-123-labeled metaiodobenzylguanidine (I-MIBG) single-photon emission computed tomography/computed tomography (SPECT/CT), which is based on the International Society of Pediatric Oncology Europe Neuroblastoma (SIOPEN) score, could improve the diagnostic efficiency of children with neuroblastoma (NB), and to compare the diagnostic ability of minimal residual disease (MRD) detection and I-MIBG SPECT/CT.

Methods: We retrospectively analyzed 238 scans of patients who underwent I-MIBG SPECT/CT at the Department of Nuclear Medicine, Beijing Friendship Hospital, from January 2021 to December 2021. The diagnostic study was not registered with a clinical trial platform, and the study protocol was not published.

View Article and Find Full Text PDF

Alternariol (AOH) and alternariol monomethyl ether (AME) are two mycotoxins with high occurrence rates in food systems. This study aimed to investigate the photodegradation of AOH and AME by ultraviolet-C (UV-C) irradiation. The effect of UV-C intensity, pH, treatment time, solvents and the exposure of food components were evaluated.

View Article and Find Full Text PDF

Focal cortical dysplasia (FCD), a malformation of cortical development, is the most common cause of intractable epilepsy in children. However, the causes and underlying molecular events of FCD need further investigation. The microarray dataset GSE62019 and GSE97365 were obtained from Gene Expression Omnibus.

View Article and Find Full Text PDF
Article Synopsis
  • Current methods for detecting early-stage hepatocellular carcinoma (HCC) are not very effective, but extracellular vesicles (EVs) show potential as biomarkers for early detection.
  • This study developed an EV-based assay to identify specific surface protein markers and create an HCC EV ECG score, which helped differentiate early-stage HCC from cirrhosis in participants.
  • The assay demonstrated high accuracy in testing, with a receiver operating characteristic area of 0.95 in the training cohort and 0.93 in the validation cohort, suggesting it could improve current HCC surveillance methods and patient outcomes.*
View Article and Find Full Text PDF

Background: Neuroblastoma (NB) is the most common tumour in children younger than 5 years old and notable for highly heterogeneous. Our aim was to quantify the intra-tumoural metabolic heterogeneity of primary tumour lesions by using F-FDG PET/CT and evaluate the prognostic value of intra-tumoural metabolic heterogeneity in NB patients.

Methods: We retrospectively enrolled 38 pretreatment NB patients in our study.

View Article and Find Full Text PDF

A 51-year-old woman was diagnosed with fulminant hepatic failure based on laboratory indexes. Contrast-enhanced CT demonstrated numerous, widespread lesions in all segments of the liver. 18 F-FDG PET/CT showed the abundant foci of increased 18 F-FDG uptake in the enlarged liver.

View Article and Find Full Text PDF

Surface-enhanced Raman scattering (SERS) has been a sensitive tool for the accurate detection and analysis of a wide range of molecules. In the present study, a simple and repeatable approach is developed for the fabrication of a silver nanocubes/polyelectrolyte/gold film (Ag nanocubes/PE/Au film) sandwich structure as SERS substrate. An ethanol-water mixture, instead of pure water, is used as solvent to reduce the coffee ring effect by the drop coating deposition method, such that Ag nanocubes are distributed evenly on the gold film surface with polyelectrolyte as the middle layer.

View Article and Find Full Text PDF

Photocatalytic nitrogen fixation represents a green alternative to the conventional Haber-Bosch process in the conversion of nitrogen to ammonia. In this study, a series of BiOBr nanostructures were synthesized via a facile, low-temperature thermal treatment procedure, and their photocatalytic activity toward nitrogen fixation was evaluated and compared. Spectroscopic measurements showed that the tubular BiOBr sample prepared at 40 °C (BiOBr-40) exhibited the highest electron-transfer rate among the series, producing a large number of O radicals and oxygen vacancies under visible-light photoirradiation and reaching a rate of photocatalytic nitrogen fixation of 12.

View Article and Find Full Text PDF

Understanding the behavior of biomolecules on nanointerface is critical in bioanalysis, which is great challenge due to the instability and the difficulty to control the orientation and loading density of biomolecules. Here, we investigated the thermodynamics and kinetics of DNA hybridization on gold nanoparticle, with the aim to improve the efficiency and speed of DNA analysis. We achieved precise and quantitative surface control by applying a recently developed poly adenines (polyA)-based assembly strategy on gold nanoparticles (DNA-AuNPs).

View Article and Find Full Text PDF

In recent years, poly adenine (polyA) DNA functionalized gold nanoparticles (AuNPs) free of modifications was fabricated with high density of DNA attachment and high hybridization ability similar to those of its thiolated counterpart. This nanoconjugate utilized poly adenine as an anchoring block for binding with the AuNPs surface thereby facilitated the appended recognition block a better upright conformation for hybridization, demonstrating its great potential to be a tunable plasmonic biosensor. It's one of the key points for any of the practical applications to maintaining stable conjugation between DNA oligonucleotides and gold nanoparticles under various experimental treatments.

View Article and Find Full Text PDF

Aggregation of α-Synuclein (α-Syn) in Lewy bodies is largely responsible for the demise and death of dopamine neurons. Oxidative stress associated with the aggregation-induced oxidative damage is considered as a possible origin of the toxicity. However, the cellular mechanism of H2O2 in the aggregation of α-Syn remains a debate, i.

View Article and Find Full Text PDF

A PHP Error was encountered

Severity: Warning

Message: fopen(/var/lib/php/sessions/ci_session4aaouokjvfv9coa0urseu4ms30s1406p): Failed to open stream: No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 177

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)

Filename: Session/Session.php

Line Number: 137

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once